Review
Medicine, General & Internal
Piotr Bargiel, Malgorzata Szczuko, Laura Stachowska, Piotr Prowans, Norbert Czapla, Marta Markowska, Jan Petriczko, Jakub Kledzik, Alicja Jedrzejczyk-Kledzik, Joanna Palma, Paulina Zabielska, Dominika Maciejewska-Markiewicz
Summary: This review summarizes the differences in the composition of intestinal microbiota in patients with thyroid diseases compared to healthy individuals, discusses the impact of microbiome on the proper functioning of the thyroid gland, and describes the association between microbiome, its metabolites, and thyroid dysfunction.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Microbiology
Xing-Xing Liao, Xiao-Yun Wu, Yu-Long Zhou, Jia-Jun Li, You-Liang Wen, Jun-Jie Zhou
Summary: Cardiovascular diseases and depression have a high comorbidity rate, but previous studies have mainly focused on individual diseases and lack research on the common pathophysiology of both diseases in comorbid states. Modern high-throughput technologies have shown that gut microbiome metabolites play important roles in the pathophysiology of AS and depression. This review summarizes the important findings on the role of gut microbiome metabolites in depression and AS disease, aiming to identify potential biological targets for the early diagnosis and treatment of AS co-depression disorders.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Weifeng Lin, Louis P. Conway, Miroslav Vujasinovic, J-Matthias Lohr, Daniel Globisch
Summary: The study developed a new chemical biology tool to overcome analytical challenges in metabolite analysis, enabling detection of over 200 metabolites in human fecal, urine, and plasma samples. This comprehensive mass spectrometric analysis enhances metabolomics-driven biomarker discovery.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Clinical Neurology
Wentian Li, Kaitao Lai, Neha Chopra, Zhaomin Zheng, Abhirup Das, Ashish D. Diwan
Summary: This review discusses the potential impact of microbiome dysbiosis on intervertebral disc degeneration (IDD) and low back pain (LBP). By changing and regulating the microenvironment of the intervertebral disc, the microbiome may play an important role in the induction and aggravation of IDD. There are three potential mechanisms by which the microbiome can trigger IDD and LBP: (1) translocation of bacteria into the intervertebral disc through the gut epithelial barrier, (2) regulation of mucosal and systemic immune responses, and (3) regulation of nutrient absorption and metabolites formation in the gut epithelium, which then diffuse into the intervertebral disc.
EUROPEAN SPINE JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Alexey A. Tinkov, Airton C. Martins, Daiana Silva Avila, Victor A. Gritsenko, Anatoly Skalny, Abel Santamaria, Eunsook Lee, Aaron B. Bowman, Michael Aschner
Summary: Manganese (Mn) exposure can lead to alterations in gut microbiota diversity and metabolite production, potentially contributing to neurotoxicity. Transplantation of healthy microbiota may alleviate Mn-induced neurotoxicity, highlighting the significant role of gut flora in Mn-mediated effects.
Article
Gastroenterology & Hepatology
Udhghatri Kolli, Richa Jalodia, Shamsudheen Moidunny, Praveen Kumar Singh, Yuguang Ban, Junyi Tao, Gonzalo Nathaniel Cantu, Eridania Valdes, Sundaram Ramakrishnan, Sabita Roy
Summary: Opioid use-associated microbial dysbiosis plays a major role in disrupting intestinal homeostasis and behavioral responses to opioids. In this study, whole genome sequencing, untargeted metabolomics, and mRNA sequencing were used to investigate the changes in microbiome, metabolome, and host transcriptome induced by morphine treatment. The results showed that morphine treatment led to significant expansion of certain bacterial species and depletion of others. Alterations in lipid metabolites and flavonoids were also observed. Furthermore, changes in microbial metabolism, host immune response, and gut barrier function were identified. The study not only provides insights into the mechanisms behind the opioid crisis, but also identifies potential therapeutic interventions.
Article
Chemistry, Multidisciplinary
Ling Wang, Yi-Xuan Tu, Lu Chen, Yuan Zhang, Xue-Ling Pan, Shu-Qiao Yang, Shuai-Jie Zhang, Sheng-Hui Li, Ke-Chun Yu, Shuo Song, Hong-Li Xu, Zhu-Cheng Yin, Jun-Qiu Yue, Qian-Lin Ni, Tang Tang, Jiu-Liang Zhang, Min Guo, Shuai Zhang, Fan Yao, Xin-Jun Liang, Zhen-Xia Chen
Summary: Men have higher incidence and mortality rates of colorectal cancer (CRC) than women. This study explains the sexual dimorphism in CRC by examining sex-biased gut microbiota and metabolites. The results show that male mice and pseudo-germ mice receiving fecal samples from males have larger tumors and impaired gut barrier function. Changes in gut microbiota composition, including increased pathogenic bacteria and decreased probiotic bacteria, were observed in male mice and pseudo-germ mice. Sex-biased gut metabolites contribute to the sex dimorphism in CRC through glycerophospholipids metabolism pathway. Modulating sex-biased gut microbiota and metabolites could be a potential therapeutic strategy for CRC.
Article
Food Science & Technology
Muhammad Shahid Riaz Rajoka, Hafiza Mahreen Mehwish, Yongai Xiong, Xun Song, Nazim Hussain, Qinchang Zhu, Zhendan He
Summary: This review discusses the roles of microbiota and nanomaterials in cancer therapy, microbiota interventions via nanomaterials, microbial inspiration via nanomaterials, and challenges associated with using nanomaterials in humans and animals. The potential of nanomaterials to alter the cancer-causing microbiome/microbiota and their metabolites, as well as the cancer microenvironment, suggests novel strategies for cancer treatment. Further in vivo clinical trials are needed to determine the exact mechanisms of action in treating cancer with nanomaterials.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yuhan Yin, Anna Sichler, Josef Ecker, Melanie Laschinger, Gerhard Liebisch, Marcus Hoering, Marijana Basic, Andre Bleich, Xue-Jun Zhang, Ludwig Kuebelsbeck, Johannes Plagge, Emely Scherer, Dirk Wohlleber, Jianye Wang, Yang Wang, Marcella Steffani, Pavel Stupakov, Yasmin Gaertner, Fabian Lohoefer, Carolin Mogler, Helmut Friess, Daniel Hartmann, Bernhard Holzmann, Norbert Hueser, Klaus-Peter Janssen
Summary: Hepatocyte growth and proliferation depend on membrane phospholipid biosynthesis, which is significantly influenced by short-chain fatty acids (SCFAs) generated through bacterial fermentation. Antibiotic treatment and dysbiosis not only affect gut microbiota, but also impair hepatic lipid synthesis and liver regeneration.
JOURNAL OF HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Yue Ma, Xiaolin Liu, Jun Wang
Summary: Research on the gut microbiome and related diseases is expanding rapidly, and new perspectives on disease development and treatment are being offered. This review explores the changes in gut microbial metabolites within complex diseases and discusses the potential causal effects of these metabolites on diseases.
Article
Critical Care Medicine
Daphne M. Moutsoglou, Jasmine Tatah, Sasha Z. Prisco, Kurt W. Prins, Christopher Staley, Sharon Lopez, Madelyn Blake, Levi Teigen, Felipe Kazmirczak, E. Kenneth Weir, Amanda J. Kabage, Weihua Guan, Alexander Khoruts, Thenappan Thenappan
Summary: Inflammation drives pulmonary arterial hypertension (PAH). This study found that patients with PAH have less diverse gut microbiome, with fewer copies of genes that produce anti-inflammatory short-chain fatty acids and secondary bile acids, and enrichment of species with genes encoding the proinflammatory metabolite trimethylamine. These findings support investigating modulation of the gut microbiome as a potential treatment for PAH.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Yujuan Li, Wencui Zhang, Tainning Sun, Baowen Liu, Anne Manyande, Weiguo Xu, Hong-Bing Xiang
Summary: The study investigated the role of gut microbiota in DCP-evoked chronic itch, using hierarchical cluster analysis to classify mice with or without cognitive dysfunction phenotype, and 16S rRNA gene sequencing to compare gut bacterial composition. Results showed that chronic itch altered microbiota composition and induced cognitive dysfunction, but the abnormal gut microbiota induced by chronic itch may not be correlated with cognitive dysfunction.
FRONTIERS IN MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jae-Kwon Jo, Gihyun Lee, Cong Duc Nguyen, Seong-Eun Park, Eun-Ju Kim, Hyun-Woo Kim, Seung-Ho Seo, Kwang-Moon Cho, Sun Jae Kwon, Jae-Hong Kim, Hong-Seok Son
Summary: Accumulated evidence suggests that gut microbiota and their metabolites influence brain function and behavior in CNS disorders. This study investigated changes in brain metabolites and fecal microbial community composition after A beta injection and donepezil treatment in mice. The findings indicate that alterations in gut microbiota may impact the development and improvement of A beta-induced cognitive dysfunction through the gut-brain axis.
Article
Microbiology
Tsegay Teklebrhan, Zhiliang Tan
Summary: Dietary amino acids can affect the fermentation metabolome and microbiome in the gastrointestinal tract of goats, leading to changes in hydrogen metabolism and methane production. The addition of sulfur-containing amino acids to the diet may be a strategy to mitigate methane emissions in ruminants.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Huanhuan Cao, Yujie Zhu, Gaofei Hu, Qi Zhang, Lemin Zheng
Summary: The treatment of atherosclerotic cardiovascular disease has mainly focused on decreasing LDL levels and targeting traditional risk factors, but the benefits have plateaued and new therapeutic targets are needed. Accumulating evidence shows that the gut microbiome plays a significant role in cardiovascular health and disease. Gut microbial metabolites, such as trimethylamine oxide (TMAO), bile acids, and amino acid metabolites, impact the development of atherosclerosis. Novel therapeutic strategies involve targeting these microbial metabolites to improve cardiovascular outcomes. Understanding these mechanisms is crucial for developing therapeutic strategies for atherosclerosis.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Behavioral Sciences
Ailin Luo, Zheng Xie, Yue Wang, Xuan Wang, Shan Li, Jing Yan, Gaofeng Zhan, Zhiqiang Zhou, Yilin Zhao, Shiyong Li
Summary: Type 2 diabetes and its associated cognitive dysfunction have significant impacts on personal health and healthcare systems. This review summarizes potential mechanisms underlying cognitive dysfunction and discusses the potential effects of anti-diabetes methods and neuroprotective natural compounds.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Neurosciences
Qiaoqiao Xu, Juan Xiong, Li Xu, Yuanyuan Wu, Man Li, Qinqin Li, Tao Jiang, Ailin Luo, Yi Zhang
Summary: Perioperative neurocognitive disorders commonly occur in elderly patients, and isoflurane could be a risk factor. This study found that the ubiquitin-proteasome system and aging may play a role in the pathogenesis of these disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Anesthesiology
Shuo Wang, Shiyong Li, Yilin Zhao, Xiaoping Zhao, Zhiqiang Zhou, Quanshui Hao, Ailin Luo, Rao Sun
Summary: This study found that a high risk of obstructive sleep apnea (OSA), as determined by screening tools, was associated with higher incidences of postoperative respiratory, cardiac, and neurological complications. However, the quality of evidence was very low, and caution is needed when interpreting the findings.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Review
Medicine, General & Internal
Wenlong Yao, Meihong Li, Chuanhan Zhang, Ailin Luo
Summary: Videolaryngoscopes have played an important role in thoracic airway management, assisting in achieving one-lung ventilation and DLT intubation. They offer advantages in improving success rates in normal airways but have limitations in difficult airways. For patients with difficult airways, videolaryngoscope-guided DLT intubation is a primary and effective method that can be combined with other techniques for lung isolation.
FRONTIERS IN MEDICINE
(2022)
Review
Physiology
Jing Yan, Xiaole Tang, Zhi-qiang Zhou, Jie Zhang, Yilin Zhao, Shiyong Li, Ailin Luo
Summary: SIRTs are a class of NAD+-dependent deacylases that regulate cell functions. CNS decline leads to impaired cognitive and social abilities, so understanding potential targets to promote CNS homeostasis is crucial.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Surgery
Hua Zheng, Xueqin Cao, Feng Gao, Xinhua Li, Li Wan, Ailin Luo
Summary: This case report highlights the potential risk of mannitol-induced hyperkalemia during neurosurgical procedures. The study suggests that male patients or patients with uncontrolled diabetes might be more susceptible to this phenomenon. It also indicates that the high dose and rapid infusion rate of mannitol could contribute to mannitol-induced hyperkalemia. Therefore, caution should be exercised when administering mannitol, especially in patients with uncontrolled diabetes, and continuous monitoring and measurement are necessary for early detection and treatment of potential life-threatening events induced by mannitol-induced hyperkalemia.
FRONTIERS IN SURGERY
(2022)
Article
Pharmacology & Pharmacy
Zheng Xie, Xuan Wang, Xiaoxiao Luo, Jing Yan, Jie Zhang, Rao Sun, Ailin Luo, Shiyong Li
Summary: This study found that neuronal ferroptosis in the hippocampus contributes to cognitive impairment in a T2D model. Furthermore, activation of AMPK can reduce hippocampal ferroptosis and improve cognitive performance in diabetic mice.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Ailin Luo, Zifeng Wu, Shan Li, Cindy B. McReynolds, Di Wang, Hanyu Liu, Chaoli Huang, Teng He, Xinying Zhang, Yuanyuan Wang, Cunming Liu, Bruce D. Hammock, Kenji Hashimoto, Chun Yang
Summary: This study investigated the relationship between chronic pain and depression and the potential benefits of inhibiting soluble epoxide hydrolase (sEH) signaling. The results showed that sEH expression was associated with pain and depression behaviors, and the sEH inhibitor TPPU improved the symptoms of both. The therapeutic effects of TPPU were mediated through the AHR and TSPO signaling pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yue Wang, Ziwen Cai, Gaofeng Zhan, Xing Li, Shan Li, Xuan Wang, Shiyong Li, Ailin Luo
Summary: Caffeic acid phenethyl ester (CAPE) can mitigate cognitive impairment caused by anesthesia and surgery by suppressing oxidative stress and promoting the switch of microglia in the hippocampus.
Review
Biochemistry & Molecular Biology
Yujuan Li, Mengxin Que, Xuan Wang, Gaofeng Zhan, Zhiqiang Zhou, Xiaoxiao Luo, Shiyong Li
Summary: Astrocytes, the most abundant cells in the brain, play a significant role in sleep regulation but their dysfunction may contribute to sleep disorders and increase the risk of other diseases. This review examines the role of astrocytes in sleep disorders, discusses potential mechanisms, and highlights the importance of further research.
Review
Nutrition & Dietetics
Mingke Guo, Xuan Wang, Yujuan Li, Ailin Luo, Yilin Zhao, Xiaoxiao Luo, Shiyong Li
Summary: As the global population ages, the prevalence of neurodegenerative diseases is increasing. Diet plays a crucial role in the development and progression of these diseases. Intermittent fasting (IF) has shown potential in improving neurological functions and reducing pathological injuries, with the gut microbiota and their metabolites believed to be central in mediating these effects.
