期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2021.750810
关键词
traumatic brain injury; blood-brain barrier; microenvironment; edema; inflammation; toxic substances; recovery
资金
- National Natural Science Foundation of China [81873096]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (Integration of Chinese and Western Medicine)
- Key Research and Development Projects of Ningxia [2021BEG02040]
- Jiangsu Chinese Medicine Science and Technology Development Project [QN202001]
- Innovative and Entrepreneurial Doctor Program of Jiangsu Province [JSSCBS20210326]
Traumatic brain injury (TBI) is associated with various pathological changes, with BBB breakdown leading to microenvironmental alterations like cerebral blood flow changes, brain edema, metabolic imbalances, and inflammatory molecule accumulation. Modulating the microenvironment presents promising targets for TBI recovery.
Traumatic brain injury (TBI) is linked to several pathologies. The blood-brain barrier (BBB) breakdown is considered to be one of the initial changes. Further, the microenvironmental alteration following TBI-induced BBB breakdown can be multiscaled, constant, and dramatic. The microenvironmental variations after disruption of BBB includes several pathological changes, such as cerebral blood flow (CBF) alteration, brain edema, cerebral metabolism imbalances, and accumulation of inflammatory molecules. The modulation of the microenvironment presents attractive targets for TBI recovery, such as reducing toxic substances, inhibiting inflammation, and promoting neurogenesis. Herein, we briefly review the pathological alterations of the microenvironmental changes following BBB breakdown and outline potential interventions for TBI recovery based on microenvironmental modulation.
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