Review
Immunology
Chuanhui Xu, Zixi Yi, Ruyi Cai, Ru Chen, Bernard Yu-Hor Thong, Rong Mu
Summary: Patients with rheumatic diseases infected with COVID-19 have a higher rate of severe outcomes, especially in Europe. More studies are needed to understand the risk factors for severe outcomes in this population.
AUTOIMMUNITY REVIEWS
(2021)
Article
Immunology
Sinem Nihal Esatoglu, Koray Tascilar, Hakan Babaoglu, Cemal Bes, Berna Yurttas, Servet Akar, Ozlem Pehlivan, Cansu Akleylek, Duygu Tecer, Emire Seyahi, Tuba Yuce-Inel, Nilufer Alpay-Kanitez, Erdal Bodakci, Emre Tekgoz, Seda Colak, Ertugrul Cagri Bolek, Suleyman Serdar Koca, Umut Kalyoncu, Ozan Cemal Icacan, Serdal Ugurlu, Hande Ece Oz, Vedat Hamuryudan, Gulen Hatemi
Summary: This study found that among patients with inflammatory rheumatic diseases (IRDs) and COVID-19, factors such as glucocorticoid use, chronic kidney disease, pulmonary disease, and obesity were associated with worse outcomes, while biologic disease-modifying antirheumatic drugs did not seem to be associated with worse outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Infectious Diseases
Ruwandi M. Kariyawasam, Tanis C. Dingle, Brittany E. Kula, Ben Vandermeer, Wendy Sligl, Ilan S. Schwartz
Summary: The prevalence, diagnosis, treatment, and outcomes of COVID-19-associated pulmonary aspergillosis (CAPA) are poorly understood, and there are discordant definitions across studies, potentially leading to an overestimation of reported prevalence.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Medicine, General & Internal
Shruti Magesh, Daniel John, Wei Tse Li, Yuxiang Li, Aidan Mattingly-app, Sharad Jain, Eric Y. Chang, Weg M. Ongkeko
Summary: This study found that members of racial and ethnic minority groups had higher risks of COVID-19 positivity and disease severity. Furthermore, socioeconomic determinants were strongly associated with COVID-19 outcomes in racial and ethnic minority populations.
Article
Medicine, General & Internal
Matthew S. Durstenfeld, Kaiwen Sun, Peggy Tahir, Michael J. Peluso, Steven G. Deeks, Mandar A. Aras, Donald J. Grandis, Carlin S. Long, Alexis Beatty, Priscilla Y. Hsue
Summary: Reduced exercise capacity is commonly reported among individuals with long COVID-19 symptoms. This study used cardiopulmonary exercise testing to compare the exercise capacity of individuals with and without long COVID-19 symptoms, finding that those with symptoms had lower exercise capacity. In addition to deconditioning, potential mechanisms for exertional intolerance include altered autonomic function, endothelial dysfunction, and muscular or mitochondrial pathology.
Article
Cell Biology
Jonathan D. Herman, Caroline Atyeo, Yonatan Zur, Claire E. Cook, Naomi J. Patel, Kathleen M. Vanni, Emily N. Kowalski, Grace Qian, Shruthi Srivatsan, Nancy A. Shadick, Deepak A. Rao, Benjamin Kellman, Colin J. Mann, Douglas Lauffenburger, Zachary S. Wallace, Jeffrey A. Sparks, Galit Alter
Summary: Alterations in humoral immunity, including weaker binding of anti-SARS-CoV-2 antibodies and stronger binding of antibodies against endemic coronavirus OC43, were observed in individuals with PASC. Previous coronavirus imprinting may serve as a potential marker for the development of PASC.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Public, Environmental & Occupational Health
Haohao Yan, Yudan Ding, Wenbin Guo
Summary: Comprehensive understanding of asymptomatic cases is important for identifying and managing patients with asymptomatic COVID-19 infection. A study in China found that 65% of initial asymptomatic COVID-19 patients did not develop any symptoms during follow-up or by the end of the disease course. Additionally, a high proportion of asymptomatic infection patients had abnormal chest CT features and tested positive for SARS-CoV-2-specific antibodies.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Hossam Waleed Almadhoon, Aboalmagd Hamdallah, Sarah Makram Elsayed, Abdulrahman Ibrahim Hagrass, Mohammed Tarek Hasan, Aya Mamdouh Fayoud, Mohammed Al-Kafarna, Mohammad Elbahnasawy, Fadel Alqatati, Khaled Mohamed Ragab, Mohamed Sayed Zaazouee, Elfatih A. Hasabo
Summary: Recent evidence suggests that influenza vaccination may reduce the clinical outcomes of COVID-19. The study found a significant reduction in the risk of mechanical ventilation for COVID-19 patients who received the influenza vaccine. However, there were no statistically significant differences in mortality rate, hospital admissions, and intensive care admissions between vaccinated and non-vaccinated groups. Further research is encouraged due to limitations in the data and the regular updates of the influenza vaccine.
SCIENTIFIC REPORTS
(2022)
Review
Behavioral Sciences
Shahrzad Nazari, Amirhossein Azari Jafari, Seyyedmohammadsadeq Mirmoeeni, Saeid Sadeghian, Mohammad Eghbal Heidari, Siavash Sadeghian, Farhad Assarzadegan, Seyed Mahmoud Puormand, Hamid Ebadi, Davood Fathi, Sahar Dalvand
Summary: This study evaluated the central nervous system (CNS) presentations in COVID-19 patients to identify common features, revealing headache, dizziness, and impaired consciousness as the most common symptoms. Understanding these CNS characteristics can aid in better diagnosis and prevention of adverse outcomes related to COVID-19.
BRAIN AND BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Pei Sen, Teresa K. Yamana, Sasikiran Kandula, Marta Galanti, Jeffrey Shaman
Summary: The COVID-19 pandemic in the United States in 2020 was characterized by increasing ascertainment rates, high population susceptibility, and rising community infectious rates, with infection fatality rate decreasing towards the end of the year.
Review
Immunology
Kuo-Tung Tang, Bo-Chueh Hsu, Der-Yuan Chen
Summary: The systematic review highlights the potential of COVID-19 to trigger various autoimmune and rheumatic manifestations, including autoimmune cytopenia, cutaneous vasculitis, encephalitis, and Guillain-Barre syndrome. While certain associations like antiphospholipid syndrome, hemophagocytic lymphohistiocytosis, and myasthenia gravis remain conflicting.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Multidisciplinary Sciences
Miriam Merad, Catherine A. Blish, Federica Sallusto, Akiko Iwasaki
Summary: Considerable research effort has been focused on deciphering the immune response to SARS-CoV-2 infections and understanding the pathophysiology of COVID-19, including Long Covid syndrome. The hope is that knowledge gained from this research will be applied to studies of inflammatory processes in critical and chronic illnesses in the future.
Review
Gastroenterology & Hepatology
Georgios Kokkotis, Konstantina Kitsou, Ioannis Xynogalas, Vana Spoulou, Gkikas Magiorkinis, Ioannis Trontzas, Panagiotis Trontzas, Garyphallia Poulakou, Konstantinos Syrigos, Giorgos Bamias
Summary: The study conducted a systematic review and meta-analysis of 84 studies, with 35 included in the meta-analysis. Results showed that COVID-19 patients receiving anti-TNF treatment had a lower probability of hospitalization and severe disease compared to non-anti-TNF patients. No difference in hospitalization risk was found for patients without COVID-19 receiving anti-TNF treatment compared to non-anti-TNF treatment.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Editorial Material
Multidisciplinary Sciences
Chris Woolston
Summary: The true impact of closed borders, cancelled travel plans and vaccine delays may take years to fully reveal.
Review
Virology
Helena C. Maltezou, Amalia Papanikolopoulou, Sofia Vassiliu, Kalliopi Theodoridou, Georgia Nikolopoulou, Nikolaos V. Sipsas
Summary: The COVID-19 pandemic has significantly affected the circulation, seasonality, and morbidity of respiratory viruses. Co-infections of SARS-CoV-2 and influenza were mainly reported during the first wave of the pandemic. However, the overall incidence of co-infections may be higher due to limited testing during that period. While animal models indicate severe lung pathology and high fatality, the clinical course and prognosis of co-infected patients remain inconclusive in human cases. It is important to consider the timing of each respiratory virus infection, but such information is lacking in reported cases. With the evolving epidemiology and availability of vaccines and treatments, early findings should not be extrapolated to the present times. Multiplex real-time PCR-based assays can improve diagnosis, infection control, and surveillance. Vaccination against both COVID-19 and influenza is crucial for high-risk groups. Further studies are needed to understand the impact and prognosis of SARS-CoV-2 and respiratory virus co-infections in the coming years.
Letter
Rheumatology
Kristin M. D'Silva, Naomi Serling-Boyd, Tiffany Y-T Hsu, Jeffrey A. Sparks, Zachary Scott Wallace
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Jeffrey A. Sparks, Zachary S. Wallace, Andrea M. Seet, Philip C. Robinson, Pedro M. Machado, Jinoos Yazdany
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Obstetrics & Gynecology
Parimala Suganthini Kanagasabai, Sara Filoche, Rebecca Grainger, Claire Henry, Jean Hay-Smith
Summary: This article aims to identify and describe the evidence on interventions to improve healthcare access of women with abnormal uterine bleeding (AUB). The study found that most interventions targeted organizational changes, such as creating a multidisciplinary team and developing a care pathway. Additionally, managing AUB in an outpatient setting improved affordability, and the use of decision aids improved patient engagement in consultations. However, there is currently a lack of interventions at an individual or community level targeting health literacy, health beliefs, social acceptability, and opportunity to reach and pay for services.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Rheumatology
Ben Darlow, Melanie Brown, Ben Hudson, Gareth Frew, Jane Clark, Loren Vincent, Rebecca Grainger, Carlo Marra, Eileen McKinlay, J. Haxby Abbott, Andrew M. Briggs
Summary: The article explores the application of a pharmacist-led service model for patients with knee osteoarthritis (OA). Through the pharmacist's professional knowledge and trustworthiness, as well as the patients' welcome and expectation of more support, better information and support can be provided for patients with knee OA.
MUSCULOSKELETAL CARE
(2023)
Editorial Material
Rheumatology
Vanessa L. Kronzer, Jeffrey A. Sparks
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Naomi J. Patel, Claire Cook, Kathleen Vanni, Xiaoqing Fu, Xiaosong Wang, Yumeko Kawano, Grace Qian, Buuthien Hang, Shruthi Srivatsan, Emily P. Banasiak, Emily Kowalski, Katarina Bade, Yuqing Zhang, Jeffrey A. Sparks, Zachary S. S. Wallace
Summary: Vaccinated patients with SARDs are less likely to experience PASC compared with those not fully vaccinated.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Medicine, General & Internal
Richard Conway, Declan G. Byrne, Deirdre O'Riordan, Bernard Silke
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Rheumatology
Patricia Harkins, Eoghan Burke, Richard Conway
Summary: Rheumatic and musculoskeletal diseases are increasingly prevalent and burdensome, yet the quality of undergraduate musculoskeletal education remains inadequate. Urgent international collaboration and further research are needed to improve the education in this field.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Medicine, General & Internal
Richard Conway, Elena Nikiphorou, Christiana A. Demetriou, Candice Low, Kelly Leamy, John G. Ryan, Ronan Kavanagh, Alexander D. Fraser, John J. Carey, Paul O'Connell, Rachael M. Flood, Ronan H. Mullan, David J. Kane, Frances Stafford, Philip C. Robinson, Jean W. Liew, Rebecca Grainger, Geraldine M. McCarthy
Summary: This study investigated the COVID-19 outcomes for individuals with rheumatic and musculoskeletal diseases in Ireland. The results showed that increasing age, gout, smoking, long-term glucocorticoid use, comorbidities, and specific comorbidities were associated with higher rates of hospitalization and mortality.
IRISH JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Rheumatology
Agnete Overgaard Donskov, Sarah Louise Mackie, Ellen Margrethe Hauge, Carlos Enrique Toro-Gutierrez, Ib Tonder Hansen, Andrea Katharina Hemmig, Aatke Van der Maas, Tamer Gheita, Berit Dalsgaard Nielsen, Karen M. J. Douglas, Richard Conway, Elena Rezus, Bhaskar Dasgupta, Sara Monti, Eric L. Matteson, Sebastian E. Sattui, Mark Matza, Vanessa Ocampo, Margarita Gromova, Rebecca Grainger, Andrea Bran, Simone Appenzeller, Annelise Goecke, Nelly Colman, Helen Keen, Masataka Kuwana, Latika Gupta, Babur Salim, Ghita Harifi, Mariam Erraoui, Nelly Ziade, Nizar Abdulateef Al-Ani, Adeola Ajibade, Johannes Knitza, Line Frolund, Max Yates, Victor R. Pimentel-Quiroz, Andre Marun Lyrio, Maria Sandovici, Kornelis S. M. Van der Geest, Toby Helliwell, Elisabeth Brouwer, Christian Dejaco, Kresten Krarup Keller
Summary: A global survey of general practitioners and rheumatologists revealed that a significant proportion of patients with polymyalgia rheumatica (PMR) are not referred for diagnosis or correctly managed, which has implications for clinical trial recruitment.
Letter
Dermatology
E. Duff, E. Gilhooley, F. O'Shea, B. Wynne
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Rheumatology
Manuel Francisco Ugarte-Gil, Rocio Violeta Gamboa-Cardenas, Cristina Reategui-Sokolova, Victor Roman Pimentel-Quiroz, Mariela Medina, Claudia Elera-Fitzcarrald, Zoila Rodriguez-Bellido, Cesar Augusto Pastor-Asurza, Risto Alfredo Perich-Campos, Graciela S. Alarcon
Summary: The objective of this study was to determine the possible predictive value of self-efficacy on health-related quality of life (HRQoL) in patients with SLE. The results showed that better self-efficacy was associated with better HRQoL, even after adjusting for possible confounders. Therefore, clinicians should develop strategies to improve self-efficacy in patients with SLE.
LUPUS SCIENCE & MEDICINE
(2023)
Article
Education & Educational Research
Qian Liu, Tehmina Gladman, Christina Grove, Sally Eberhard, Susan Geertshuis, Anthony Ali, Phil Blyth, Rebecca Grainger
Summary: Research shows that students use technologies beyond what institutions provide, while most studies in Internet-enabled learning focus on institutional or staff technologies. This misalignment may result in universities' online technologies being only partially relevant to student learning. By interviewing and analyzing 22 students from three New Zealand universities, the study reveals that students use non-institutional technologies to enhance institutional offerings, as they find institutional technologies overloaded with information and non-institutional technologies expedient in processing information and empowering their own learning. The study also identifies differences in technology use between high and low-achieving students, linked to motivation, technology awareness, and metacognition. It highlights the significance of non-institutional technologies in learning and has implications for future research, institutional technology design and implementation, and student preparation in technology-enhanced learning.
INTERNET AND HIGHER EDUCATION
(2023)
Editorial Material
Rheumatology
Kanon Jatuworapruk, Rebecca Grainger
LANCET RHEUMATOLOGY
(2023)
Article
Rheumatology
Pedro M. Machado, Martin Schaefer, Satveer K. Mahil, Jean Liew, Laure Gossec, Nick Dand, Alexander Pfeil, Anja Strangfeld, Anne Constanze Regierer, Bruno Fautrel, Carla Gimena Alonso, Carla G. S. Saad, Christopher E. M. Griffiths, Claudia Lomater, Corinne Miceli-Richard, Daniel Wendling, Deshire Alpizar Rodriguez, Dieter Wiek, Elsa F. Mateus, Emily Sirotich, Enrique R. Soriano, Francinne Machado Ribeiro, Felipe Omura, Frederico Rajao Martins, Helena Santos, Jonathan Dau, Jonathan N. Barker, Jonathan Hausmann, Kimme L. Hyrich, Lianne Gensler, Ligia Silva, Lindsay Jacobsohn, Loreto Carmona, Marcelo M. Pinheiro, Marcos David Zelaya, Maria de los Angeles Severina, Mark Yates, Maureen Dubreuil, Monique Gore-Massy, Nicoletta Romeo, Nigil Haroon, Paul Sufka, Rebecca Grainger, Rebecca Hasseli, Saskia Lawson-Tovey, Suleman Bhana, Thao Pham, Tor Olofsson, Wilson Bautista-Molano, Zachary S. Wallace, Zenas Z. N. Yiu, Jinoos Yazdany, Philip C. Robinson, Catherine H. Smith
Summary: This study investigated factors associated with severe COVID-19 in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis. The study found that age, sex, comorbidities, disease activity, and glucocorticoid use were associated with the severity of COVID-19. Additionally, later pandemic time periods, psoriasis, and the use of TNFi, IL17i, and IL-23i/IL-12+23i were associated with a reduced risk of severe COVID-19.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
