Article
Cardiac & Cardiovascular Systems
Andre Rivera, Bruno Campos, Stephanie Ceolin, Amanda Godoi, Everton Castanha, Carlos Alberto Campello Jorge, Rhanderson Cardoso
Summary: This study aimed to determine the impact of a polypill-based strategy (PBS) on therapeutic adherence and cardiovascular outcomes compared with usual care for secondary prevention of cardiovascular diseases (CVDs) through a systematic review and meta-analysis of randomized controlled trials (RCTs). The results showed that PBS significantly improved therapeutic adherence, systolic blood pressure (SBP), and LDL-cholesterol (LDL-C), and reduced cardiovascular mortality. Therefore, PBS may be considered as a preferred option for patients with pre-existing CVD.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Mohamed M. G. Mohamed, Mohammed Osman, Babikir Kheiri, Maryam Saleem, Alexandre Lacasse, Mohamad Alkhouli
Summary: This meta-analysis demonstrates that the use of polypills is significantly associated with reductions in blood pressure and blood lipid levels compared to standard of care, leading to a significant decrease in cardiovascular events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lilian Grigorian-Shamagian, Klaus Edel, Maria Asuncion Esteve-Pastor, Alvaro Acena, Claudia Silva, Joana Delgado-Silva, Georges Ntaios, Eftychia Demerouti, Carlos Brotons
Summary: The main objective of cardiovascular disease prevention is to reduce morbidity and mortality. Using a cardiovascular polypill can help improve risk factor control, especially in patients with uncontrolled risk factors.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Xing Wang, Dingke Wen, Yuqi Chen, Lu Ma, Chao You
Summary: This study evaluated the benefit and safety of different types of PCSK9 inhibitors for secondary prevention in patients with high-risk of cardiovascular events. The results showed that alirocumab was associated with reduced all-cause mortality and decreased risk of serious adverse events, while evolocumab was associated with increased all-cause mortality compared to alirocumab.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Shreya Rao, Tariq Jamal Siddiqi, Muhammad Shahzeb Khan, Erin D. Michos, Ann Marie Navar, Thomas J. Wang, Stephen J. Greene, Dorairaj Prabhakaran, Amit Khera, Ambarish Pandey
Summary: Polypill use is associated with reductions in cardiovascular disease risk factors, total mortality risk, and major adverse cardiovascular events, particularly in low-risk and primary prevention populations.
PROGRESS IN CARDIOVASCULAR DISEASES
(2022)
Review
Cardiac & Cardiovascular Systems
Stefania Angela Di Fusco, Stefano Aquilani, Antonella Spinelli, Alessandro Alonzo, Andrea Matteucci, Lorenzo Castello, Giuseppe Imperoli, Furio Colivicchi
Summary: The polypill strategy has shown promise in improving treatment adherence for cardiovascular disease. Recently published results from a clinical trial focused on secondary prevention demonstrate a reduction in major adverse cardiovascular events. This finding supports the broader implementation of polypill therapy for cardiovascular disease prevention.
PROGRESS IN CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Shahin Merat, Elham Jafari, Amir Reza Radmard, Masoud Khoshnia, Maryam Sharafkhah, Alireza Nateghi Baygi, Tom Marshall, Abolfazl Shiravi Khuzani, Kar Keung Cheng, Hossein Poustchi, Reza Malekzadeh
Summary: Fixed-dose combination therapy is effective for preventing major cardiovascular events in individuals with and without presumed non-alcoholic steatohepatitis (pNASH). Among participants with fatty liver and elevated liver enzymes, the use of a polypill can reduce liver enzyme levels.
EUROPEAN HEART JOURNAL
(2022)
Review
Cardiac & Cardiovascular Systems
Liangying Deng, Qing Wu, Feng Ding, Yanfeng Liu, Jianping Shen, Yan Lin, Kaihu Shi, Bailin Zeng, Lixing Wu, Huangjin Tong
Summary: This systematic review evaluated the efficiency of telemedicine for the secondary prevention of arteriosclerotic cardiovascular disease (ASCVD) and provided evidence for its application. The results showed that telemedicine, especially when using telephone intervention, had a positive impact on certain risk factors, physical activity, and exercise. However, there were controversies regarding the improvement of medication adherence, exercise compliance, muscle function, healthy diet, knowledge score, self-efficacy, and economy through telemedicine.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Houyong Zhu, Xiaoqun Xu, Hanxin Wang, Qilan Chen, Xiaojiang Fang, Jianwu Zheng, Beibei Gao, Guoxin Tong, Liang Zhou, Tielong Chen, Jinyu Huang
Summary: This study compared the efficacy and safety of different treatment methods in stable cardiovascular disease (SCVD) patients at high ischemic risk. The results showed that combination therapy can reduce the risk of major cardiovascular and cerebrovascular events, but also increases the risk of bleeding. Overall, we recommend monotherapy as the first choice for high ischemic risk patients, but combination therapy can be considered for patients with recurrent major cardiovascular and cerebrovascular events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Sport Sciences
Vicente Martinez-Vizcaino, Francisco J. Amaro-Gahete, Ruben Fernandez-Rodriguez, Miriam Garrido-Miguel, Ivan Cavero-Redondo, Diana P. Pozuelo-Carrascosa
Summary: The study found that both exercise and polypills were effective in reducing low-density lipoprotein cholesterol and total cholesterol, but only exercise interventions improved high-density lipoprotein cholesterol levels and decreased triglycerides. The polypill without antiplatelet therapy was identified as the most effective pharmacological treatment for improving the lipid profile, while aerobic interval exercise was the most effective exercise intervention.
Article
Multidisciplinary Sciences
Julien Castioni, Nazanin Abolhassani, Peter Vollenweider, Gerard Waeber, Pedro Marques-Vidal
Summary: A study in Switzerland found that a large fraction of the population is eligible for the polypill, but only one-third of them actually benefits from an equivalent, and this proportion did not change over time.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Jose M. Castellano, Stuart J. Pocock, Deepak L. Bhatt, Antonio J. Quesada, Ruth Owen, Antonio Fernandez-Ortiz, Pedro L. Sanchez, Francisco Marin Ortuno, Jose M. Vazquez Rodriguez, Alexandra Domingo-Fernandez, Inigo Lozano, Maria C. Roncaglioni, Marta Baviera, Andreana Foresta, Luisa Ojeda-Fernandez, Furio Colivicchi, Stefania A. Di Fusco, Wolfram Doehner, Antje Meyer, Francois Schiele, Fiona Ecarnot, Ales Linhart, Jean-Claude Lubanda, Gregory Barczi, Bela Merkely, Piotr Ponikowski, Marta Kasprzak, Juan M. Fernandez Alvira, Vicente Andres, Hector Bueno, Timothy Collier, Frans Van de Werf, Pablo Perel, Moises Rodriguez-Manero, Angeles Alonso Garcia, Marco Proietti, Mikkel M. Schoos, Tabassome Simon, Jose Fernandez Ferro, Nicolas Lopez, Ettore Beghi, Yannick Bejot, David Vivas, Alberto Cordero, Borja Ibanez, Valentin Fuster
Summary: The study showed that taking a polypill containing aspirin, ramipril, and atorvastatin within 6 months after myocardial infarction significantly reduced the risk of major adverse cardiovascular events compared to usual care.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jose R. Gonzalez-Juanatey, Alberto Cordero, Jose Ma Castellano, Luis Masana, Regina Dalmau, Emilio Ruiz, Antonio Sicras-Mainar, Valentin Fuster
Summary: This study suggests that treatment with the CNIC-Polypill in secondary prevention patients is associated with a significant reduction in the incidence of recurrent MACE, improved control rates for blood pressure and LDL cholesterol, and increased medication persistence compared to control groups.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Letter
Medicine, General & Internal
Kurt Stoschitzky
Summary: In the SECURE trial, it was found that the use of a polypill containing aspirin, ramipril, and atorvastatin significantly reduced the risk of cardiovascular events in older patients with recent myocardial infarction. However, the absence of beta-blockers in this polypill raised questions as these drugs have been known to be effective after myocardial infarction and are recommended in current guidelines.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Pasquale Perrone-Filardi, Paola Minghetti, Enrica Menditto, Stefano Bianchi, Francesco Scaglione, Gianluca Trifiro, Gaetano Piccinocchi, Tiberio Corona, Giorgia Gambarelli, Chiara Izzi, Vincenzo Misciagna, Daria Putignano, Stefania Lopatriello, Davide Cafiero
Summary: This study aimed to reach a consensus on the value of polypill in cardiovascular disease by a multidisciplinary Italian panel. Through a three-step modified Delphi method, experts in cardiology, pharmacy, general practice, pharmacology, and health economics reached consensus on the effectiveness of polypill in reducing cardiovascular events, blood pressure, improving therapeutic adherence and having a better cost-effectiveness profile.
JOURNAL OF CARDIOVASCULAR MEDICINE
(2021)
Article
Education, Special
Joanna Ting Wai Chu, Jessica C. McCormack, Samantha Marsh, Chris Bullen
Summary: This study examines the knowledge, attitudes, awareness, and practices of education professionals in Aotearoa New Zealand regarding Fetal Alcohol Spectrum Disorder (FASD). The findings highlight the gaps in knowledge and emphasize the need to support individuals with FASD in educational settings.
JOURNAL OF INTELLECTUAL DISABILITIES
(2023)
Article
Endocrinology & Metabolism
Anna J. Wood, I-Lynn Lee, Elizabeth L. M. Barr, Federica Barzi, Jacqueline A. Boyle, Christine Connors, Elizabeth Moore, Jeremy J. N. Oats, Harold D. McIntyre, Angela Titmuss, Alison Simmonds, Paul Z. Zimmet, Alex D. H. Brown, Sumaria Corpus, Jonathan E. Shaw, Louise J. Maple-Brown
Summary: This study aimed to determine the rates and predictors of postpartum diabetes screening among Aboriginal and/or Torres Strait Islander and non-Indigenous women with gestational diabetes mellitus (GDM). The study found that postpartum screening rates were lower among Aboriginal and/or Torres Strait Islander women compared to non-Indigenous women. Early postpartum screening should be prioritized to detect prediabetes and diabetes among high-risk populations.
Article
Peripheral Vascular Disease
Xuejun Yin, Ellie Paige, Maoyi Tian, Qiang Li, Liping Huang, Jie Yu, Anthony Rodgers, Paul Elliott, Yangfeng Wu, Bruce Neal
Summary: The SSaSS study found that potassium-enriched salt can have definitive effects on cardiovascular outcomes and death. By quantifying the amount of potassium-enriched salt used, researchers were able to estimate the impact on risk reduction and the potential for population-wide scale-up. The results showed that even a partial replacement of regular salt with potassium-enriched salt can deliver significant health gains.
Article
Health Care Sciences & Services
Helen Eyles, Jacqueline Grey, Yannan Jiang, Elaine Umali, Rachael McLean, Lisa Te Morenga, Bruce Neal, Anthony Rodgers, Robert N. Doughty, Cliona Ni Mhurchu
Summary: The study aimed to determine whether a 12-week intervention with a sodium-reduction package comprising the SaltSwitch smartphone app and reduced-sodium salts could reduce urinary sodium excretion in adults with high blood pressure. However, the study found no evidence that dietary sodium intake was reduced in adults with high blood pressure. This may be due to lower engagement with the trial intervention package by participants.
JMIR MHEALTH AND UHEALTH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Clare Arnott, Bruce Neal
EUROPEAN HEART JOURNAL
(2023)
Article
Nutrition & Dietetics
Emalie Rosewarne, Joseph Alvin Santos, Gian Luca Di Tanna, Maria Shahid, Carley Grimes, Kristy A. Bolton, Jacqui Webster, Bruce Neal, Mark Woodward, Daisy Coyle, Kathy Trieu
Summary: The media advocacy strategy implemented by the Victorian Salt Reduction Partnership did not lead to a significant reduction in sodium levels of targeted packaged food products. The study suggests that media advocacy activities alone are insufficient to lower average sodium levels in packaged foods without government leadership and measurable sodium targets.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Article
Clinical Neurology
Anna H. Balabanski, Lee Nedkoff, Alex Brown, Amanda G. Thrift, Odette Pearson, Steven Guthridge, Angela Dos Santos, Timothy J. Kleinig, Judith M. Katzenellenbogen
Summary: The study compared the incidence of stroke between Aboriginal and non-Aboriginal populations in Australia and found that stroke occurred more commonly and at younger ages in the Aboriginal population. It suggests the need for improved primary prevention strategies and culturally appropriate community-based health promotion and support for nonmetropolitan health services.
Article
Medicine, General & Internal
Romany McGuffog, Catherine Chamberlain, Jaqui Hughes, Kelvin Kong, Mark Wenitong, Jamie Bryant, Alex Brown, Sandra J. Eades, Kalinda E. Griffiths, Felicity Collis, Breanne Hobden, Peter O'Mara, Tanika Ridgeway, Maggie Walter, Michelle Kennedy
Summary: The Murru Minya study aims to examine the implementation of ethical processes in health research with Aboriginal and Torres Strait Islander people in Australia. A mixed-methods design will be used to collect knowledge and experiences from various key groups and develop practical recommendations for ethical conduct in future research. The study has received ethical approval and has been developed in collaboration with Aboriginal and Torres Strait Islander researchers, organizations, and communities.
Review
Medicine, General & Internal
Papillon Gustafson, Yasmin Abdul Aziz, Michelle Lambert, Karen Bartholomew, Rachel Brown, Peter Carswell, Adam Fusheini, Mihi Ratima, Patricia Priest, Sue Crengle
Summary: This article describes a protocol for a scoping review that focuses on ethnicity-related health inequities and aims to identify equity-focused implementation science theories, models, and frameworks. The review will analyze the evidence relating to the factors that aid or inhibit equitable implementation of health interventions.
Article
Medicine, General & Internal
Jesse Whitehead, Gabrielle Davie, Brandon de Graaf, Sue Crengle, Ross Lawrenson, Rory Miller, Garry Nixon
Summary: This study found that the identification of rural-urban health disparities in Aotearoa New Zealand varied significantly depending on the classification system used. The rural population mortality rates were substantially higher when using the geographic classification system (GCH) compared to the generic-urban-rural experimental profile (UREP) and urban accessibility (UA) classifications. Overall, the rural-urban all-cause mortality incidence rate ratios (IRRs) were higher with the GCH compared to the UA and UREP. This pattern was also observed among the Maori population.
Review
Cardiac & Cardiovascular Systems
Nelson Wang, Phidias Rueter, Emily Atkins, Ruth Webster, Mark Huffman, Asita de Silva, Clara Chow, Anushka Patel, Anthony Rodgers
Summary: Low-dose combination (LDC) antihypertensives consisting of 3 or 4 blood pressure-lowering drugs have shown to be an effective and well-tolerated treatment option for initial management of hypertension. LDC therapy resulted in greater reduction in systolic blood pressure and higher proportion of patients achieving target blood pressure compared to monotherapy or placebo. The findings support the importance of considering LDC therapy for hypertension management.
Article
Health Care Sciences & Services
W. Li, V. Cornelius, S. Finfer, B. Venkatesh, L. Billot
Summary: Adaptive clinical trials are increasing in popularity for assessing COVID-19 treatments, but their use in critical care trials is still limited.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Article
Endocrinology & Metabolism
Yashdeep Gupta, Deksha Kapoor, Josyula K. Lakshmi, Devarsetty Praveen, Joseph Alvin Santos, Laurent Billot, Aliya Naheed, H. Asita de Silva, Ishita Gupta, Noshin Farzana, Renu John, Saumiyah Ajanthan, Neerja Bhatla, Ankush Desai, Arunasalam Pathmeswaran, Dorairaj Prabhakaran, Helena Teede, Sophia Zoungas, Anushka Patel, Nikhil Tandon
Summary: The aim of this study was to investigate the incidence and risk factors for postpartum diabetes in women with gestational diabetes mellitus from South Asia. The results showed a high incidence of postpartum diabetes in this population, with significant variation between countries. Women from Bangladesh had higher rates of diabetes and more risk factors compared to Sri Lanka and India.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Green & Sustainable Science & Technology
Allison M. Gaines, Tazman Davies, Maria Shahid, Fraser Taylor, Jason HY. Wu, Michalis Hadjikakou, Simone Pettigrew, Paraskevi Seferidi, Bruce Neal
Summary: This study developed a novel approach to estimate product-specific greenhouse gas emissions (GHGe) for packaged foods and beverages in Australia. The results showed significant variations in GHGe estimates among different food categories, with meat products having the highest emissions and fruits, vegetables, nuts, and legumes having the lowest emissions. These data are important for driving industry actions and informing government policies.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Medicine, General & Internal
Caitlin M. P. Jones, Richard O. Day, Bart W. Koes, Jane Latimer, Chris G. Maher, Andrew J. McLachlan, Laurent Billot, Sana Shan, Chung-Wei Christine Lin
Summary: This study investigated the efficacy and safety of opioid analgesics for acute low back pain and neck pain. The results showed no significant difference in pain severity compared with placebo, indicating that opioids should not be recommended for these conditions.