Therapeutic potential of mangiferin against kidney disorders and its mechanism of action: A review

There is a swing in research developments concerning the utilization of natural products as effective pharmacotherapeutic agents due to their comparatively lower toxicities than synthetic compounds. Among natural products, mangiferin is a natural C-glucosyl xanthonoid polyphenol with remarkable pharmacological activities. Emerging evidence indicates the therapeutic benefits of mangiferin against various kidney disorders, including renal injury, diabetic nephropathy, renal fibrosis, hyperuricemic nephropathy, and lupus nephritis, in experimental animal models. The mangiferin induced antioxidant response resulting in vital functions, such as protection against renal inflammation, inhibits renal cell apoptosis, activates autophagy, causes immunomodulation, regulates renal urate transporters and mod-ulates cell signalling pathways. The purpose of this review provide a brief overview of the in vitro/in vivo reno-protective effect of mangiferin and the underlying mechanism(s) in protecting against kidney dis -orders. Understanding the pharmacological actions of mangiferin is prominence due to its excellent ther-apeutic potential in managing kidney disorders. Thus, in addition to this review, in-silico molecular docking is performed against nuclear factor kappa B (NF-kappa B) and soluble epoxide hydrolase (sEH) to study the mechanism of action of mangiferin. It is believed that mangiferin is a safe reno-protective mole -cule. The observed positive effects are attributed to the inhibition of inflammation caused by NF-kappa B and sEH upregulation and oxidative stress activation. Studies on the efficacy and safety of mangiferin in clin-ical trials are further warranted to confirm its medicinal potential as therapeutic agent for kidney disor-ders in humans. (C) 2021 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

Automated summary

Mangiferin, a natural product, exhibits therapeutic benefits against various kidney disorders in animal models through antioxidant responses and regulation of physiological functions. It is considered a safe reno-protective molecule that protects the kidneys by inhibiting inflammation and oxidative stress. Further clinical trials are needed to confirm its potential as a therapeutic agent for kidney disorders in humans.