Article
Cell Biology
Purvi Purohit, Dipayan Roy, Shailendra Dwivedi, Naresh Nebhinani, Praveen Sharma
Summary: The study found that individuals with chronic opioid use disorder had elevated levels of inflammatory cytokines TNF-alpha and IL-10, while IL-6 was reduced. There was a dose-dependent upregulation of miR-155-5p and miR-187-5p at opium doses greater than 1500 g/month, along with an increase in TNF-alpha and IL-10.
Article
Endocrinology & Metabolism
Kangkang Huang, Yunlai Liang, Yating Ma, Jiahui Wu, Huidan Luo, Bin Yi
Summary: This study discovered significant variations in adiponectin, nesfatin-1, IL-6, and TNF-alpha levels among healthy individuals, prediabetic patients, and type 2 diabetes mellitus patients, indicating a gradual change during the progression from a healthy condition to diabetes via prediabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Himangshu Sonowal, Hongying Zhang, William Rice, Stephen B. Howell
Summary: The multikinase inhibitor Luxeptinib demonstrates the ability to inhibit the release of IL-1 beta, IL-6, and TNF alpha from monocytes and macrophages, making it a potential treatment for inflammatory diseases and inflammation-associated resistance in cancer. The mechanism involves disabling caspase-1 and inhibiting multiple kinases.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Nikolaos Skartsis, Yani Peng, Leonardo M. R. Ferreira, Vinh Nguyen, Emilie Ronin, Yannick D. Muller, Flavio Vincenti, Qizhi Tang
Summary: The study shows that human Tregs respond positively to proinflammatory cytokines, enhancing proliferation without affecting their lineage identity or function, providing a potential method for therapeutic Treg manufacturing.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Jianya Ye, Haiyan Ye, Minghui Wang, Yanjun Zhao
Summary: The combined use of methylprednisolone and antibiotics significantly improves the levels of serum inflammatory factors and clinical symptoms in children with bronchopneumonia compared to monotherapy with methylprednisolone. The group treated with combination therapy showed higher effective rates, lower expression levels of TNF-C and IL-6, shorter resolution times of symptoms, lower asthma control test scores, and lower incidence of adverse reactions.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Cell Biology
Areej Al-Roub, Ashraf Al Madhoun, Nadeem Akhter, Reeby Thomas, Lavina Miranda, Texy Jacob, Ebaa Al-Ozairi, Fahd Al-Mulla, Sardar Sindhu, Rasheed Ahmad
Summary: The overexpression of IL-6 in the adipose tissue of obese individuals may lead to insulin resistance. IL-1 beta and TNF alpha, which are increased in obese adipose tissue, cooperate to enhance the production of IL-6 in adipocytes. This cooperative interaction depends on CREB binding and H3K14 acetylation and provides an interesting pathophysiological connection among IL-1 beta, TNF alpha, and IL-6 in obesity settings.
Article
Immunology
Alexandria Lozowchuk, Judith E. Carroll, Calvin Hobel, Mary Coussons-Read, Christine Dunkel Schetter, Kharah M. Ross
Summary: This study explored the relationship between partner relationship quality and inflammatory markers IL-6, IL-10, and TNF-alpha during pregnancy and the postpartum period. The findings suggest that lower partner support may be associated with reduced inflammation regulation, with potential consequences for maternal health and well-being.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Review
Chemistry, Medicinal
Alvaro Nobrega de Melo Madureira, Joao Ricardhis Saturnino de Oliveira, Vera Lucia de Menezes Lima
Summary: Interleulcin-6 (IL-6) is a myokine that can be released by exercising skeletal muscle. It activates the PI3K-Akt pathway to enhance insulin signaling and glycogen synthesis. IL-6 also increases GLUT-4 vesicle mobilization and may contribute to muscle hypertrophy by activating mTORC1 and promoting contractile protein synthesis.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Food Science & Technology
M. L. Cuellar-Nunez, E. Gonzalez de Mejia, G. Loarca-Pina
Summary: Moringa oleifera leaves have shown chemopreventive properties against inflammatory response and colon carcinogenesis by modulating gene expression and reducing proinflammatory mediators.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Neurosciences
Donna L. Gruol, Delilah Calderon, Katharine French, Claudia Melkonian, Salvador Huitron-Resendiz, Chelsea Cates-Gatto, Amanda J. Roberts
Summary: The neuroimmune system of the brain, primarily composed of astrocytes and microglia, regulates homeostatic mechanisms crucial for normal brain function. Alcohol consumption and neuroimmune factors, such as proinflammatory cytokines IL-6 and TNF-alpha, disrupt this regulation by acting on common targets in the brain. Recent studies suggest that IL-6 plays a role in alcohol drinking and its effects on brain activity, but more research is needed.
Article
Biochemistry & Molecular Biology
Jihye Yoo, Jiyoung Park, Darong Kim, Yeonjoo Huh, Hea-Young Park Choo, Hyun Ae Woo
Summary: By synthesizing 12 novel compounds and evaluating their biological activities, it was found that 4 compounds exhibited strong inhibitory activities on IL-1 beta and IL-6 mRNA expression. Further in vivo activity evaluation indicated that 2 compounds significantly decreased mRNA levels of IL-1 beta, IL-6, and TNF-alpha.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Ilin Kandilarov, Petya Gardjeva, Maria Georgieva-Kotetarova, Hristina Zlatanova, Natalia Vilmosh, Ivanka Kostadinova, Mariana Katsarova, Kiril Atliev, Stela Dimitrova
Summary: This study aimed to investigate the effects of two combined plant extracts, rich in flavonoids, on cytokine levels in rats subjected to acute and chronic stress models. The results showed that these combined extracts had a more pronounced effect in reducing cytokine levels compared to individual plant extracts.
Article
Biochemistry & Molecular Biology
Katia Azarfar, Parichehreh Yaghmaei, Mahsa M. Amoli, Nasim Hayati-Roodbari, Azadeh Ebrahim-Habibi
Summary: The study aimed to observe the effects of silymarin on localized insulin-generated amyloidosis. It was found that incubating regular insulin and injecting it subcutaneously into rats led to the formation of amyloid fibrils, while silymarin could decrease the deposition of amyloids. Furthermore, silymarin also attenuated the concentration and gene expression of inflammatory factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Bazgha Gul, Rukhsana Anwar, Mohammad Saleem, Afifa Noor, Muhammad Ihsan Ullah
Summary: The current study evaluated the anti-arthritic activity of n-hexane and aqueous extracts of Cassia absus seeds. The extracts showed significant inhibition of paw edema and reduction in paw size and joint diameter. The extracts also improved the levels of inflammatory and oxidative biomarkers. Polymerase chain reaction investigation revealed the modulation of various inflammatory factors by the extracts. In conclusion, Cassia absus can effectively alleviate arthritis symptoms by modulating oxidative and inflammatory biomarkers.
INFLAMMOPHARMACOLOGY
(2023)
Article
Psychiatry
Hannah E. Specht, Nina Mannig, Meriem Belheouane, Nadia Andrea Andreani, Klaus Tenbrock, Ronald Biemann, Katrin Borucki, Brigitte Dahmen, Astrid Dempfle, John F. Baines, Beate Herpertz-Dahlmann, Jochen Seitz
Summary: This study aimed to explore the role of inflammation in patients with anorexia nervosa (AN). The results showed that the inflammatory response was higher in adolescent patients at admission, but differed from adults as the levels of interleukin-1 beta (IL-1 beta) and IL-6 were lower. Additionally, the gut microbiota may play a regulatory role in the inflammatory processes of AN.
FRONTIERS IN PSYCHIATRY
(2022)