期刊
JOURNAL OF NANOBIOTECHNOLOGY
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12951-021-01175-x
关键词
Resveratrol; Macrophage; Periodontitis; Liposome; Immune microenvironment; Local delivery
资金
- National Key Research and Development Program of China (China) [2021YFE0103100]
- NFSC [81925035, 81771116, 81521005]
- Shanghai SciTech Innovation Initiative [19431903100, 18430740800]
- Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine [YBKA201906]
A therapeutic resveratrol-loaded liposomal system (Lipo-RSV) was developed to treat periodontitis, showing good biocompatibility and ability to regulate inflammatory macrophages, as well as reduce the release of pro-inflammatory cytokines.
Background Periodontitis is a complicated inflammatory disease that damages the tooth-supporting tissues, with limited pharmacotherapy available. Macrophage-targeting therapy is promising for inflammatory diseases. Resveratrol (RSV), a nonflavonoid polyphenol, is known for its anti-inflammatory and immunomodulatory effects. However, its medical application is limited by its poor stability and water-solubility, as well as its low bioavailability. Result A therapeutic resveratrol-loaded liposomal system (Lipo-RSV) was developed to treat periodontitis. The physical properties of Lipo-RSV and its ability to regulate macrophages were investigated. The results showed that Lipo-RSV had good biocompatibility and could re-educate the inflammatory macrophages from M1- to M2-like phenotype through activating p-STAT3 and downregulating p-STAT1. Besides, the Lipo-RSV could scavenge ROS and inhibit the NF-kappa B signal and inflammasomes, thereby reducing the pro-inflammatory cytokines IL-1 beta, IL-6, and TNF-alpha. Conclusion These results revealed that Lipo-RSV could be a potential therapeutic system for the antibiotic-free treatment for periodontal diseases.
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