Nampt activator P7C3 ameliorates diabetes and improves skeletal muscle function modulating cell metabolism and lipid mediators

P7C3‐A20, a neuroprotective agent, alleviates fatty liver by inducing FGF21/FGF1 in a LKB1/AMPK/CRTC2‐dependent manner and shaping gut microbiota

(2020) Xia Hua et al.   BRITISH JOURNAL OF PHARMACOLOGY

Adolescent Obesity and Early-Onset Type 2 Diabetes

(2020) Gilad Twig et al.   DIABETES CARE

The skeletal muscles of mice infected with Plasmodium berghei and Plasmodium chabaudi reveal a crosstalk between lipid mediators and gene expression

(2020) Mauro Toledo Marrelli et al.   MALARIA JOURNAL

Deletion of SREBF1, a functional bone-muscle pleiotropic gene, alters bone density and lipid signaling in zebrafish

(2020) Chen Shochat et al.   ENDOCRINOLOGY

Pathophysiology of Type 2 Diabetes Mellitus

(2020) Unai Galicia-Garcia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship

(2019) Jakub Mesinovic et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Differential Expression of Human N-Alpha-Acetyltransferase 40 (hNAA40), Nicotinamide Phosphoribosyltransferase (NAMPT) and Sirtuin-1 (SIRT-1) Pathway in Obesity and T2DM: Modulation by Metformin and Macronutrient Intake

(2019) Awad Alshahrani et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation

(2018) K. C. Chapalamadugu et al.   Acta Physiologica

Perturbations of NAD+ salvage systems impact mitochondrial function and energy homeostasis in mouse myoblasts and intact skeletal muscle

(2018) Marianne Agerholm et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

From SNPs to pathways: Biological interpretation of type 2 diabetes (T2DM) genome wide association study (GWAS) results

(2018) Elisa Cirillo et al.   PLoS One

P7C3 inhibits GSK3β activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo

(2017) Chao Gu et al.   Cell Death & Disease

Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes

(2017) Leif Väremo et al.   Genome Medicine

Muscle dysfunction in type 2 diabetes: a major threat to patient’s mobility and independence

(2016) Lara Bianchi et al.   ACTA DIABETOLOGICA

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

(2016) David W. Frederick et al.   Cell Metabolism

Diabetes and Cancer: a Review of Current Knowledge

(2016) J. Wojciechowska et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Mitochondrial fat oxidation is essential for lipid-induced inflammation in skeletal muscle in mice

(2016) Jaycob D. Warfel et al.   Scientific Reports

HDL-cholesterol and cardiovascular disease

(2015) Hasan K. Siddiqi et al.   CURRENT OPINION IN CARDIOLOGY

Human Adipocytes Induce Inflammation and Atrophy in Muscle Cells During Obesity

(2015) Vanessa Pellegrinelli et al.   DIABETES

Physiological and pathophysiological roles of NAMPT and NAD metabolism

(2015) Antje Garten et al.   Nature Reviews Endocrinology

High level of oxygen treatment causes cardiotoxicity with arrhythmias and redox modulation

(2015) Kalyan C. Chapalamadugu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

(2014) Gelin Wang et al.   CELL

Triglycerides and cardiovascular disease

(2014) Børge G Nordestgaard et al.   LANCET

Network-based target ranking for polypharmacological therapies

(2013) Francesca Vitali et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Inflammation Is Necessary for Long-Term but Not Short-Term High-Fat Diet-Induced Insulin Resistance

(2011) Y. S. Lee et al.   DIABETES

Cannabinoids Inhibit Insulin Receptor Signaling in Pancreatic  -Cells

(2011) W. Kim et al.   DIABETES

The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise

(2011) Jørgen Jensen et al.   Frontiers in Physiology

Discovery of a Proneurogenic, Neuroprotective Chemical

(2010) Andrew A. Pieper et al.   CELL

Antidiabetic activity of cycloart-23-ene-3β, 25-diol (B2) isolated from Pongamia pinnata (L. Pierre) in streptozotocin–nicotinamide induced diabetic mice

(2010) Sachin L. Badole et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Relationship Between Cerebrospinal Fluid Visfatin (PBEF/Nampt) Levels and Adiposity in Humans

(2008) M. Hallschmid et al.   DIABETES

Type 2 Diabetes Mellitus and Skeletal Muscle Metabolic Function

(2008) Esther Phielix et al.   PHYSIOLOGY & BEHAVIOR