期刊
CHEMISTRYOPEN
卷 11, 期 4, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/open.202100251
关键词
alcohol dehydrogenases; anti-Prelog; asymmetric reduction; biocatalysis; enantiopure alcohols
资金
- Deanship of Scientific Research (DSR) at King Fahd University of Petroleum and Minerals (KFUPM) [DF191007]
This review covers examples of synthesizing optically active alcohols using ADHs that exhibit anti-Prelog stereopreference, including both wild-type and engineered ADHs.
Biocatalytic production of both enantiomers of optically active alcohols with high enantiopurities is of great interest in industry. Alcohol dehydrogenases (ADHs) represent an important class of enzymes that could be used as catalysts to produce optically active alcohols from their corresponding prochiral ketones. This review covers examples of the synthesis of optically active alcohols using ADHs that exhibit anti-Prelog stereopreference. Both wild-type and engineered ADHs that exhibit anti-Prelog stereopreference are highlighted.
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