期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 12, 期 3, 页码 273-282出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.14951
关键词
Pancreatic Ductal Adenocarcinoma; Chemotherapeutic Resistance; Hypoxia; HuR; DNA Damage
资金
- NIH-NIGMS [T32 GM008562 20]
- Mary Halinski Pancreatic Cancer Research Fund
- Fund for a Cure, Nancy Kay Engel Pancreatic Cancer Research Fund
- Elkan Katz Memorial Fund for Pancreatic Cancer Research
Pancreatic cancer (pancreatic ductal adenocarcinoma, PDA) is infamously moving to the top of the list as one of the most lethal cancers with an overall 5 year survival rate of 7%. Multiple genomic-based and molecular characterization studies of PDA specimens and established animal models have provided the field with multiple targets and a progression model of this disease. Still, to date, the best therapeutic options are surgery and combination cytotoxic therapies. In general, even in the best case scenario (i.e., an early stage diagnosis and a response to a specific therapy), most of these fortunate patients' PDA cells acquire or exert resistance mechanisms and eventually kill the patient. Herein, we touch on a growing field of investigation that focuses on PDA cell therapeutic resistance mechanisms. We examine extrinsic elements (i.e., the tumor microenvironment, hypoxia) to the intrinsic processes within the cell (i.e., post-transcriptional gene regulation and somatic mutations) that are important for therapeutic efficacy and resistance. Even as better targeted and personalized approaches move through the clinical trial pipeline the discussed resistance mechanisms will most likely play a role in the management of this deadly disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据