Article
Biochemistry & Molecular Biology
Ying Li, Xiu-Er Luo, Ming-Jun Tan, Fu-Hao Yue, Run-Yu Yao, Xin-An Zeng, Meng-Wai Woo, Qing-Hui Wen, Zhong Han
Summary: In this study, a novel hydrogel microbeads, consisting of carboxymethylcellulose / ZnO / chitosan and loaded with crosslinked porous starch / curcumin, were designed and prepared. The microbeads exhibited enhanced encapsulation efficiency of curcumin for drug delivery to specific sites. The pH-sensitive drug delivery system showed good drug stability and bioavailability, making it suitable for targeting drug delivery to the small intestine.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biophysics
Mohammad Akrami-Hasan-Kohal, Mahnaz Eskandari, Atefeh Solouk
Summary: The study developed a sustained release formulation using dexamethasone sodium phosphate-loaded chitosan nanoparticles embedded in silk fibroin hydrogel. The scanning electron microscopy showed the prepared drug delivery system had a properly interconnected porous structure, indicating potential for drug delivery applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Applied
Somaye Rashki, Kasra Asgarpour, Hossein Tarrahimofrad, Maryam Hashemipour, Mohammad Saeid Ebrahimi, Hadis Fathizadeh, Ahmad Khorshidi, Haroon Khan, Zeynab Marzhoseyni, Masoud Salavati-Niasari, Hamed Mirzaei
Summary: Chitosan nanomaterials have gained attention in biomedicine for their high levels of biodegradability and biocompatibility, along with antimicrobial effects. Functional modification with other natural compounds, metallic antimicrobial particles, and antibiotics can enhance the efficiency of chitosan in wound dressing with antimicrobial activity. The antibacterial effect of chitosan is mainly associated with the leakage of intracellular content due to malfunction and altered permeability of the negatively charged cell membrane, on which chitosan is adsorbed. Additionally, chitosan nanoparticles possess favorable features of nanoparticles and their chitosan base, thereby exhibiting strengthened antibacterial potential. Polycations in chitosan nanoparticles target negatively charged bacterial membranes, resulting in a stronger effect on bacterial cells compared to pure chitosan.
CARBOHYDRATE POLYMERS
(2021)
Review
Polymer Science
Karen Guillen-Carvajal, Benjamin Valdez-Salas, Ernesto Beltran-Partida, Jorge Salomon-Carlos, Nelson Cheng
Summary: Hydrogels are versatile biomaterials with three-dimensional, cross-linked, highly hydrated polymeric networks. They have a variety of biochemical and biophysical properties, allowing for diffusion of diverse molecules and control of cellular interactions. Hydrogels can be molded into different structures resembling surrounding tissues and bone defects. Their application in bone tissue engineering has garnered significant attention due to the beneficial bone improvement results achieved. Synthetic polymers have played a key role, but there is a trend towards using biological precursors like chitosan, collagen, and gelatin for their high biocompatibility, degradability, and mechanical control.
Article
Polymer Science
Regina R. Vildanova, Svetlana F. Petrova, Sergey V. Kolesov, Vitaliy V. Khutoryanskiy
Summary: Preparation of stable hydrogels using charge-complementary polyelectrolyte chains offers practical advantages over the use of organic crosslinking agents. This study utilizes natural polyelectrolytes-chitosan and pectin-with their biocompatibility and biodegradability. Different molecular weights of pectin are used to prepare hydrogels with varying rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels can release the cytostatic drug cisplatin over an extended period, potentially improving the effectiveness of cancer treatment.
Article
Biochemistry & Molecular Biology
Nagi M. El-Shafai, Shaymaa Shawky, Ibrahim M. El-Mehasseb, Maged A. El-Kemary
Summary: The research focused on the application of sandwich nanohybrid of nano-PVA and nano-chitosan in water treatment and drug adsorption, revealing their potential effects through tests on photocatalytic activity and release efficiency. Additionally, studies on cytotoxicity and antioxidant properties were conducted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Julia Radwan-Praglowska, Lukasz Janus, Marek Piatkowski, Aleksandra Sierakowska, Ernest Szajna, Dalibor Matysek, Dariusz Bogdal
Summary: Epilepsy is a common neurological disease that can have a significant negative impact on quality of life, especially when symptoms are drug-resistant. Cannabidiol, derived from Cannabis Sativa, offers new hope for epilepsy treatment, with potential benefits in increasing bioactivity through transdermal delivery.
Review
Pharmacology & Pharmacy
Xiangjie Di, Xiao Liang, Chao Shen, Yuwen Pei, Bin Wu, Zhiyao He
Summary: This review surveys carbohydrate-based or carbohydrate-modified drug delivery systems and their applications in disease therapy. Polymeric carbohydrates have advantages of nontoxicity, biocompatibility, and biodegradability, making them an ideal choice for drug targeting, sustained drug release, immune antigens, and adjuvants.
Article
Biochemistry & Molecular Biology
Marcel Jakubowski, Aleksandra Domke, Maria Ratajczak, Joanna Szczuka, Tomasz Buchwald, Adam Voelkel, Mariusz Sandomierski
Summary: Osteoporosis is a widespread disease. Bisphosphonates are commonly used drugs for its treatment, but they have limitations. This paper focuses on the development of a hydrogel material modified with lanthanum for sustained and slow release of Zoledronate. The research found that the hydrogel is capable of long-term release, making it suitable for implantable hydrogel or coating for local drug delivery on titanium implants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Xiaochun Yin, Meixia Du, Zhongming Sun, Hai Zhu, Pei Xu, Huiyao Wang
Summary: Keratin/chitosan hybrid hydrogels were developed by integrating keratin with chitosan through alkaline freeze-thaw cycles. The resulting hydrogels exhibited honeycomb-like structures and excellent mechanical properties. Hydrogel C, with a keratin/chitosan ratio of 3/2, showed the highest compressive stress and strain. It also demonstrated effective controlled release profiles for different drugs at varying pH and temperatures.
EUROPEAN POLYMER JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Yuhan Xia, Zhiyuan Ma, Xuechen Wu, Huidan Wei, Han Zhang, Guang Li, Yuqi Qian, Mina Shahriari-Khalaji, Kai Hou, Ran Cao, Meifang Zhu
Summary: Sustainable and controllable drug transport is an efficient method for disease treatment. Chitosan hydrogel, characterized by high biocompatibility, good biodegradability, and low costs, has been widely used in biomedical fields. The abundant amino and hydroxyl groups in chitosan hydrogel allow it to interact with human tissues and enable drugs to pass through biological barriers. The multi-responsive nature of chitosan hydrogel, including pH, temperature, ions strength, and magnetic field, makes precise drug release possible. This review summarizes the synthesis methods, modification strategies, stimuli-responsive mechanisms, and recent progress of chitosan-based hydrogels in drug delivery, focusing on subcutaneous, oral, and facial administration. The challenges towards clinical application and future prospects are also discussed.
MACROMOLECULAR BIOSCIENCE
(2023)
Review
Biotechnology & Applied Microbiology
Hamed Kazemi Shariat Panahi, Mona Dehhaghi, Hamid Amiri, Gilles J. Guillemin, Vijai Kumar Gupta, Ahmad Rajaei, Yadong Yang, Wanxi Peng, Junting Pan, Mortaza Aghbashlo, Meisam Tabatabaei
Summary: The article introduces the importance of chitosan and its derivative chitin in biomaterials, particularly in terms of their antimicrobial, antioxidant, and anticancer activities. The article also points out some drawbacks in the structure of chitosan and discusses a modification method using lactose and galactose as main raw materials to prepare soluble branched chitosan.
BIOTECHNOLOGY ADVANCES
(2023)
Article
Chemistry, Multidisciplinary
V Muthulakshmi, G. R. Rajarajeswari
Summary: Drug-loaded biopolymeric films with pectin-chitosan blends showed enhanced thermal stability, mechanical strength, and antibacterial properties. Among the prepared films, PC4/CC1.5 demonstrated optimal performance and was effective in wound dressing applications with superior wound healing ability in in vivo studies. The curcumin-loaded film holds great potential for further clinical studies.
NEW JOURNAL OF CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Chong Yu, Shuai Wang, Wing-Fu Lai, Dahong Zhang
Summary: Bladder cancer (BC) is the most common cancer of the urinary system and non-muscle-invasive bladder cancer (NMIBC) accounts for the majority of cases. Patients with NMIBC have a good survival rate but are at high risk for tumor recurrence and progression. The use of antitumor agents instilled into the bladder is the standard treatment for NMIBC, but their efficacy is limited due to chemo-resistance and poor drug retention. Chitosan-based nanoparticles offer a promising solution by enhancing drug penetration and improving biomedical applications in bladder cancer treatment.
Article
Spectroscopy
Nagi M. El-Shafai, Ahmed I. Nada, Mahmoud A. Farrag, Kahdr Alatawi, Adel I. Alalawy, Salhah D. Al-Qahtani, Ibrahim M. El-Mehasseb
Summary: The aim of this study was to create a novel hybrid nanocomposite (Cs@Pyc.SOF) by combining the hepatitis C virus (HCV) drug sofosbuvir with the nano antioxidant pycnogenol and nano biomolecules like chitosan nanoparticles. The nanocomposite was characterized using various techniques, and the results showed high loading efficiency and release rate, as well as good viability against tested cell lines.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Pharmacology & Pharmacy
Solmaz Mojarad-Jabali, Masoud Farshbaf, Salar Hemmati, Muhammad Sarfraz, Hamidreza Motasadizadeh, Javid Shahbazi Mojarrad, Fatemeh Atyabi, Parvin Zakeri-Milani, Hadi Valizadeh
Summary: The development of a modified liposomal formulation has shown promising results in facilitating brain targeted delivery and selective accumulation within glioma cells. Among the studied targeting ligands, T7-modified liposomes demonstrated superior BBB penetration, brain distribution, and increased accumulation in glioma cells, leading to improved anti-glioma outcomes through targeted cytotoxicity and apoptosis. These results suggest that T7-modified liposomes could serve as a potential platform for effective brain targeted delivery and glioma therapy in clinical settings.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Hassan Farhadnejad, Seyed Alireza Mortazavi, Sanaz Jamshidfar, Amir Rakhshani, Hamidreza Motasadizadeh, Yousef Fatahi, Athar Mahdieh, Behzad Darbasizadeh
Summary: The present study fabricated mucoadhesive bio-nanocomposite hydrogels to prolong the drug retention time in the stomach. These hydrogels exhibited controllable and sustainable drug release, enhanced mucoadhesion, and prolonged retention time in the stomach, leading to increased therapeutic efficacy and bioavailability.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Masoud Farshbaf, Solmaz Mojarad-Jabali, Salar Hemmati, Ahmad Yari Khosroushahi, Hamidreza Motasadizadeh, Amir Zarebkohan, Hadi Valizadeh
Summary: This study developed a targeted delivery system based on nanostructured lipid carriers, which can effectively overcome the blood-brain barrier and blood-brain tumor barrier, and deliver therapeutics to glioma cells with high selectivity. It represents a promising treatment for brain cancer.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Marjan Soleimanpour, Samaneh Sadat Mirhaji, Samira Jafari, Hossein Derakhshankhah, Fatemeh Mamashli, Hadi Nedaei, Mohammad Reza Karimi, Hamidreza Motasadizadeh, Yousef Fatahi, Atiyeh Ghasemi, Maryam Sadat Nezamtaheri, Mohadese Khajezade, Masoumeh Teimouri, Bahram Goliaei, Cedric Delattre, Ali Akbar Saboury
Summary: This study designed and fabricated an effective wound dressing by combining appropriate coagulating and anti-bacterial materials. The fabricated wound dressing exhibited stable structure, antibacterial activity, and high biocompatibility. In vivo experiments confirmed its effectiveness in promoting wound healing.
SCIENTIFIC REPORTS
(2022)
Article
Biophysics
Sareh Aghajanpour, Mehdi Esfandyari-Manesh, Tahmineh Ghahri, Mohammad Hossein Ghahremani, Fatemeh Atyabi, Mostafa Heydari, Hamidreza Motasadizadeh, Rassoul Dinarvand
Summary: This study developed a 3D bio-printed osteogenic scaffold using alginate hydrogel, human bone marrow-derived mesenchymal stem cells (hBM-MSCs), calcium peroxide nanoparticles (CPO NPs) for oxygen generation, and bone morphogenic protein-2 nanoparticles (BMP2 NPs) as an osteoinductive growth factor. The scaffold with 3% CPO NPs showed improved viability of embedded hBM-MSCs and upregulated osteogenic gene expression. This research contributes to the advancement of stem cell therapy and tissue healing in low oxygen pressure conditions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Elham Jamshidifar, Mehdi Esfandyari-Manesh, Hamidreza Motasadizadeh, Sara Naderizadeh, Alaleh Yourdkhani, Nasrin Samadi, Rassoul Dinarvand
Summary: In this study, GelMA-alginate-gelatin scaffold loaded with antibacterial and osteoinductive agents showed promising potential for the treatment of osteomyelitis.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Chemistry, Applied
Hamidreza Motasadizadeh, Sara Azizi, Alireza Shaabani, Mostafa Ghodrati Sarvestani, Roya Sedghi, Rassoul Dinarvand
Summary: A novel wound healing system with multifunctional properties was prepared in this study, showing excellent mechanical, structural, and biological properties. The CS-g-PNVIM-based nanofibers exhibited promising potential for biocompatible antibacterial wound dressing applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Sepideh Yoosefi, Amir Rakhshani, Vahideh Montazeri, Mohamadreza Tavakoli, Amin Aliabadi, Yousef Fatahi, Helia Behrouzfar, Shadi Keihankhadiv, Behzad Darbasizadeh, Hamidreza Motasadizadeh, Hassan Farhadnejad
Summary: The present study aimed to improve wound healing rate using LDH-VAN/IBU/CMC-PEO bionanocomposite fibrous mats. The fabricated mats showed sustained drug release and no cytotoxicity, and could accelerate the wound healing process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Athar Mahdieh, Hamidreza Motasadizadeh, Hamid Yeganeh, Bo Nystrom, Rassoul Dinarvand
Summary: Clickable and cleavable nanomicelles with stimuli-responsiveness have been developed for targeted drug delivery to tumor tissues, showing potential value in breast cancer therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Amirreza Mansoori-Kermani, Sadaf Khalighi, Iman Akbarzadeh, Fazeleh Ranjbar Niavol, Hamidreza Motasadizadeh, Athar Mahdieh, Vahid Jahed, Masoud Abdinezhad, Nikoo Rahbariasr, Mahshid Hosseini, Nima Ahmadkhani, Behnam Panahi, Yousef Fatahi, Masoud Mozafari, Alan Prem Kumar, Ebrahim Mostafavi
Summary: An optimized system of HA-coated nanocarriers has been developed for targeted breast cancer treatment. The system showed reduced drug release, increased cytotoxicity and apoptosis in vitro, and CD44-mediated cellular uptake mechanism. In vivo experiments demonstrated significant tumor volume reduction without side effects.
MATERIALS TODAY BIO
(2022)
Article
Biochemistry & Molecular Biology
Samaneh Sadat Mirhaji, Marjan Soleimanpour, Hossein Derakhshankhah, Samira Jafari, Fatemeh Mamashli, Meisam Rooki, Mohammad Reza Karimi, Hadi Nedaei, Mitra Pirhaghi, Hamidreza Motasadizadeh, Atiyeh Ghasemi, Maryam Sadat Nezamtaheri, Fatemeh Saadatpour, Bahram Goliaei, Cedric Delattre, Ali Akbar Saboury
Summary: We have developed an innovative wound dressing using chitosan, fibrinogen, nisin, and EDTA as an effective antibacterial scaffold for wound treatment. The hydrogel exhibited good mechanical properties, drug encapsulation and release, swelling behaviors, blood coagulation, cytotoxicity, and antibacterial activity. Cell studies demonstrated biocompatibility, non-toxicity, and promotion of cell migration. In vivo data showed enhanced tissue regeneration and recovery within 17 days. Overall, this innovatively designed hydrogel shows good potential as a candidate for wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Fatemeh Hassaninejad Farahani, Fatemeh Moraffah, Nasrin Samadi, Mohammad Sharifzadeh, Hamidreza Motasadizadeh, Alireza Vatanara
Summary: Lactiplantibacillus plantarum cells were encapsulated in a mixture of cationic and anionic polymers and freeze-dried, resulting in a stable composition. The effects of polymer concentrations and prebiotics on probiotic viability and swelling behavior were examined using a D-optimal design. The optimized formulation showed a viability percentage of over 82% and should be stored refrigerated. In vivo testing demonstrated improved wound healing indicators and the ability to modify wound inflammatory responses, making it comparable to silver sulfadiazine ointment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Maryam Rajabzadeh-Khosroshahi, Mohammad Mahdi Eshaghi, Erfan Rahmani, Hamidreza Motasadizadeh, Rabia Arshad, Abbas Rahdar, Sadanand Pandey
Summary: In biomedical engineering, researchers are studying the modification of TiO2 (titania) to enhance its physiochemical properties. This comprehensive review focuses on the potential applications of nanoscale TiO2 and its nanocomposites in biomedical research, specifically in cancer therapeutics. The use of titania-based nanomaterials in biosensors, particularly in the electrochemical field, has been widely explored. Various bioimaging techniques, such as FL, PA, CT, PET, MR, and multi-mode imaging, have been evaluated for their applicability. Nanoscale titania has also emerged as a popular candidate for cancer treatment methods including phototherapy, chemotherapy, and microwave hyperthermia. Finally, a multifunctional nanoplatform combining different treatment methods has been developed for cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Biomaterials
Hamidreza Motasadizadeh, Mohamadreza Tavakoli, Sheyda Damoogh, Fatemeh Mottaghitalab, Mahdi Gholami, Fatemeh Atyabi, Mehdi Farokhi, Rassoul Dinarvand
Summary: In this study, a pH-sensitive silk fibroin (SF)/sodium alginate (SA) hydrogel scaffold containing teicoplanin (TEC) and phenamil (PM) loaded SF nanoparticles (PMSFNPs) was introduced for the treatment of chronic osteomyelitis. The results showed sustained and pH-sensitive release of TEC and PM from the hydrogel scaffold, with higher release rates at alkaline pH compared to neutral and acidic pH. The released TEC maintained its antibacterial activity for 35 days at different pH values. Cell studies also demonstrated that the scaffolds containing PMSFNPs promoted cell viability, ALP activity, and matrix mineralization. In vivo evaluations on infected rat bones showed lower infection and higher regeneration in the group treated with the hydrogel scaffold containing PMSFNPs and TEC compared to other groups. Therefore, this dual-drug delivery system holds promise for effective treatment of chronic bone infection.
BIOMATERIALS ADVANCES
(2022)
Article
Nanoscience & Nanotechnology
Ali Moammeri, Koorosh Abbaspour, Alireza Zafarian, Elham Jamshidifar, Hamidreza Motasadizadeh, Farnaz Dabbagh Moghaddam, Zeinab Salehi, Pooyan Makvandi, Rassoul Dinarvand
Summary: This study evaluated the anticancer effect of decorated niosomal nanocarriers loaded with cisplatin and epirubicin in breast cancer cells and mice, showing promising potential for breast cancer treatment.
ACS APPLIED BIO MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
