期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 84, 期 -, 页码 31-34出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2015.11.089
关键词
Hydrogel nanoparticles; Transmission electron microscopy; Chitosan; Methotrexate
资金
- Shiraz University of Medical Sciences [94.01.36.10309]
Nanogels are potential polymeric nanoparticulate systems of interest in biomedical applications, including time-controlled drug delivery and active drug targeting. With the aim of preparation of a nanocarrier for brain enhancement of the BBB-restricted hydrophilic drugs, nanogel loaded with the antineoplasm drug, methotrexate was prepared using an ionic gelation process. During transmission electron microscopy imaging, hydrogel nanoparticles were found as a polymeric matrix containing aqueous vacuoles. With emitting the electrons and increase in energy intake, the vacuoles were interconnected and form a large one. Then the volume of the new vacuole grew and subsequently decreased over the time. The behavior was in good agreement with drug release kinetic findings. These results provide important guidelines for designing top-down fabricated hydrogel nanoparticles with specific drug release kinetic mechanisms for enhancing and predicting the drug delivery efficacy. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据