Article
Biochemistry & Molecular Biology
Shasha Yu, Xiaodan Dong, Haiyu Ji, Juan Yu, Anjun Liu
Summary: The polysaccharide PTP from Polygala tenuifolia Willd. was found to induce apoptosis in human lung cancer cells through the FAS/FAS-L pathway. Furthermore, PTP demonstrated antitumor activity and immunoregulation for S180 sarcoma cells in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Critical Care Medicine
Xiaoyan Yu, Jingyi Chen, Hong Tang, Qianqian Tu, Yue Li, Xi Yuan, Xuemei Zhang, Ju Cao, David Paul Molloy, Yibing Yin, Dapeng Chen, Zhixin Song, Pingyong Xu
Summary: This study reveals the significant role of Prokineticin2 in the clinical diagnosis and treatment of sepsis. Prokineticin2 protects against sepsis-induced death by regulating macrophage function, presenting a new strategy for sepsis immunotherapy.
CRITICAL CARE MEDICINE
(2022)
Article
Oncology
Xupu Wang, Lizheng Wang, Wenmo Liu, Xinyao Liu, Xinyuan Jia, Xinyao Feng, Fangshen Li, Rui Zhu, Jiahao Yu, Haihong Zhang, Hui Wu, Jiaxin Wu, Chu Wang, Bin Yu, Xianghui Yu
Summary: The study reveals that recombinant TRAIL not only induces tumor cell apoptosis, but also influences the cancer immune microenvironment, providing important perspectives for novel TRAIL strategies in tumor therapy.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Hong Liu, Run He, Xuliang Yang, Bo Huang, Hongxiang Liu
Summary: This study aimed to elucidate the regulatory mechanism of transcription factor 21 (TCF21) on the immunosuppressive effect of tumor-associated macrophages (TAM) in non-small cell lung cancer (NSCLC). The experimental results showed that overexpression of TCF21 promoted the polarization of TAM into an immunostimulatory state and enhanced the viability of T cells. Additionally, there may be a targeting relationship between TCF21 and Notch.
Article
Engineering, Biomedical
Yulin Jiang, Juehan Wang, Dan Sun, Zheng Liu, Lin Qi, Meixuan Du, Jing Wang, Yubao Li, Ce Zhu, Yong Huang, Yueming Song, Limin Liu, Ganjun Feng, Li Zhang
Summary: This study developed a self-contained injectable hydrogel capable of storing Mg2+ and carrying nucleus pulposus cells to inhibit intervertebral disc degeneration through immunoregulation. The hydrogel showed biocompatibility and enhanced the expression of collagen II and aggrecan. Its potential in intervertebral disc repair was demonstrated in vivo.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Xin Ge, Junfeng Hu, Yuan Peng, Zhuo Zeng, Danfeng He, Xilan Li, Yajie Chen, Gaoxing Luo, Jun Deng, Zhigang Xu, Song He
Summary: This study successfully delivered interleukin-4 (IL-4) into the inflammatory microenvironment by constructing a multilayered protective nanoarmor, which enabled M2 macrophage polarization and downregulation of inflammatory mediators for the treatment of inflammatory bowel disease (IBD). Additionally, the system improved gut microbiota dysbiosis, inhibited inflammation, and promoted colitis tissue repair.
Review
Plant Sciences
Qiu-Ping Liu, Yu-Ying Chen, Pei An, Khalid Rahman, Xin Luan, Hong Zhang
Summary: Macrophages in the tumor microenvironment (TME) can polarize into M2 type, which promotes tumor development. This review summarizes the effects of TME on macrophage polarization and the reversal of M2 polarization by natural products, providing directions for tumor therapy.
Article
Biophysics
Shuqi Zhang, Jiazhen Long, Lin Chen, Jie Zhang, Yunjian Fan, Jiayu Shi, Yuanjin Huang
Summary: Poly(etheretherketone) (PEEK) is a promising material for repairing bone and dental hard tissue defects due to its chemical stability, biocompatibility, and mechanical properties. However, it has disadvantages such as biological and chemical inertness, which affect the integration of implants and bonding strength of prostheses. This review explores methods to improve PEEK's antibacterial and immunomodulatory abilities, addressing limitations, future challenges, and required research efforts.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Dan Liu, Shu-Yue Wang, Guan-Nan Wang, Li-Hua Zheng, Ying Sun, Lei Liu, Yong -Li Bao
Summary: In this study, the structural characteristics and immunoregulatory activities of a neutral heteropolysaccharide (AVRP-N) isolated from the roots of Apocynum venetum L. were extensively investigated. The results revealed that AVRP-N has a weight average molecular mass of 6.430 x 103 Da. The backbone consists of naturally acetylated (1 -> 4)-beta-D-Man and (1 -> 5)-alpha-L-Ara domains. AVRP-N also exhibited a triple-helix conformation. Furthermore, AVRP-N showed immunomodulatory effects by enhancing cytokine secretion and regulating the proliferation of mouse splenic lymphocytes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Plant Sciences
Meng Meng, Lianfu Wang, Yang Yao, Dongmei Lin, Changyuan Wang, Jialin Yao, Huijun Sun, Mozhen Liu
Summary: This study found that Ganoderma lucidum polysaccharide peptide (GLPP) can effectively alleviate symptoms of arthritis and exert its effects by inhibiting the NF-kappa B and MAPK pathways. This provides evidence for the potential therapeutic effect of mushroom-derived polysaccharide peptides in the treatment of rheumatoid arthritis (RA).
Article
Nutrition & Dietetics
Caixuan Zhang, Ying Shu, Yang Li, Mingzhu Guo
Summary: In this study, the structural features of a polysaccharide obtained from Craterellus cornucopioides were investigated, and its immunoregulatory effects were evaluated. The polysaccharide showed remarkable immunological activity and activation of macrophages in vitro, and also exhibited protective function against immunosuppression induced by cyclophosphamide. Moreover, it was found that the polysaccharide could activate macrophages through the TLR4-NF kappa B p65 pathway. These findings provide meaningful information for further research on the immune mechanism.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Weijie Zhang, Guanghua Mao, Weiwei Feng, Yao Chen, Min Zhang, Qian Li, Xiangyang Wu, Guangying Cheng, Liuqing Yang, Ting Zhao
Summary: The present study investigated the immunomodulatory effects and mechanisms of AEFP22 in CTX-induced immunosuppressed mice. AEFP22 significantly improved nonspecific immunity, humoral immunity, cellular immunity, and the status of immune organs. Serum immunoglobulins, cytokines, and nitric oxide levels were also increased. Transcriptome analysis showed inverse regulation of immune-related genes in the AEFP22-treated group. AEFP22 exhibited immunoregulatory activity by enhancing toll-like receptor 4 (TLR4), myeloid differentiation primary response gene 88 (MyD88), TNF receptor associated factor 6 (TRAF6), and major histocompatibility complex class II (MHC II) expression, promoting MAPK phosphorylation, and facilitating NF-κB nuclear translocation.
PROCESS BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Yi Chen, Pei Chen, Huiping Liu, Yumei Zhang, Xiaowei Zhang
Summary: A cold-water soluble polysaccharide (PCP-4) has been extracted from Penthorum chinense Pursh and found to inhibit the proliferation of liver cancer cells and induce apoptosis both in vitro and in vivo. These findings highlight the potential therapeutic value of PCP-4 for hepatocellular carcinoma.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Min Zhu, Xiaotao Wu, Jun Sun, Zhou Zhou, Mingzhu Kang, Yiwei Hu, Liping Teng
Summary: This study aimed to evaluate the immunoregulatory effects of NDesulfated reacetylated derivative of heparin (NDeSAcH) on macrophage polarization. The findings indicated that NDeSAcH could effectively promote the release of nitric oxide (NO), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in RAW264.7 cells compared to heparin. NDeSAcH also significantly inhibited the production of NO, IL-6, and TNF-alpha in LPS-induced RAW264.7 cells, while suppressing the secretion of transforming growth factor-beta (TGF-beta) in M2 macrophages. These results suggest that NDeSAcH may be a promising candidate for modulating macrophage polarization and treating inflammation-related diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nutrition & Dietetics
Dongshuai Qu, Shuaitao Lian, Hongjie Hu, Wenjing Sun, Hongbin Si
Summary: This study elucidates the physicochemical properties and immunomodulatory activity of two polysaccharides (ACP(t0) and ACP(t2)) from Abrus cantoniensis. The results demonstrate that ACP(t0) and ACP(t2) exhibit immunomodulatory activity by promoting cell proliferation, enhancing phagocytosis, and releasing immune molecules. Moreover, they activate specific signaling pathways to exert immunomodulatory effects. ACP(t2) shows higher immunomodulatory activity than ACP(t0), suggesting its potential application in the food and pharmaceutical industries.
FRONTIERS IN NUTRITION
(2022)
Article
Management
Xiaogang Lin, Danna Chen, Yong-Wu Zhou, Qiang Lin
Summary: This study examines the impact of mergers between low carbon manufacturers on prices and carbon emissions, with findings on carbon emission collusion and green technology investment cost synergies and their implications. The research shows that merging manufacturers could charge lower prices but increase carbon emissions even without the two sources of cost savings. Additionally, it suggests that production cost synergies can lead to a win-win outcome for manufacturers, consumers, and the environment in certain scenarios.
EUROPEAN JOURNAL OF OPERATIONAL RESEARCH
(2022)
Article
Chemistry, Analytical
Qizhi He, Shuheng Ma, Jingya Wang, Keke Chen, Jun Dong, Ji Zhou, Danna Chen, Yi Ning
Summary: A bioassay using graphene oxide (GO) and nicking enzyme (Nb.BbvC I) for detecting Pseudomonas aeruginosa showed high sensitivity and specificity. It performed well in the analysis of water samples, making it a promising method for clinical diagnosis of infectious diseases.
ANALYTICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Wanjun Gong, Lingdong Jiang, Yanxia Zhu, Mengna Jiang, Danyang Chen, Zhaokui Jin, Shucun Qin, Zhiqiang Yu, Qianjun He
Summary: A catalytic hydrogenation strategy was proposed to design and synthesize a ratiometric fluorescent probe, enabling in vitro and in vivo fluorescence imaging of hydrogen molecules. The developed probe exhibits high sensitivity, rapid responsivity, high selectivity, and low detection limit, allowing for rapid and real-time detection of hydrogen molecules.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Optics
Dan Chen, Yanrong Liu, Feier Ai, Minghua Cao
Summary: The pulse response expression of the non-line-of-sight underwater laser channel is derived based on the binomial Henyey-Greenstein scattering phase function, considering the forward and backward effects. The effectiveness of the established underwater photon transmission channel model is simulated and verified, showing better fitting effects in coastal waters. The pulse-broadening factor is higher in coastal waters compared to harbor waters, and the time-domain broadening effect of laser pulse transmission is significant in harbor waters, particularly influenced by front scattering when the asymmetry factor is large.
OPTICAL ENGINEERING
(2022)
Article
Mechanics
Danyang Chen, Zhideng Zhou, Xiaolei Yang
Summary: A novel MCPNN-frozen model is proposed in this study for wind resource assessment, utilizing neural networks and frozen flow hypothesis. Results indicate the model performs well under certain conditions.
Article
Multidisciplinary Sciences
Yingwen Hu, Danyang Chen, John Napoleon, Madduri Srinivasarao, Sunil Singhal, Cagri A. Savran, Philip S. Low
Summary: The combination of folate-biotin conjugates and magnetic beads can efficiently capture tumor cells, which has been validated in both mouse models and non-small cell lung cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Liu Jinyu, Wang Shuying, Zheng Panchan, Chen Dan, Chen Chao, Yang Xingyu, Cheng Weiwei
Summary: The expression of BST2 and MMP2 is significantly downregulated in preeclampsia. Overexpression of BST2 can upregulate MMP2 expression and enhance the migration and invasion capacity of trophoblast cells. Knockdown of BST2 or MMP2 has opposite effects. These results suggest that the downregulation of BST2 may play a role in the pathogenesis of preeclampsia.
Article
Engineering, Biomedical
Lingdong Jiang, Danyang Chen, Zhaokui Jin, Chao Xia, Qingqing Xu, Mingjian Fan, Yunlu Dai, Jia Liu, Yuanpei Li, Qianjun He
Summary: In this study, a peptide-based nanoparticle was developed for tumor-targeted delivery of nanomedicine. The nanoparticle could release nitric oxide (NO) and undergo structural transformation upon light irradiation, leading to enhanced intratumoral retention and sensitizing photodynamic therapy (PDT).
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Yue Fu, Hu Zhao, Yunming Wang, Dan Chen, Zhaohan Yu, Jiaqi Zheng, Shuang Sun, Weihao Cai, Huamin Zhou
Summary: In this study, a new fabrication strategy was employed to achieve three-dimensional photonic crystal-light emitting (PC-LE) devices with dual iridescent and reversible photochromic colors. Additionally, inkless color printing was realized through the etching process, generating a reversible and encrypted colorful bar code. This research opens up new possibilities for advanced display, color printing, and anticounterfeiting stickers.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Acoustics
Dandan Chen, Juan Xia, Shurui Xie, Yafeng He, Xiaojing Ma
Summary: This case report highlights the successful diagnosis and treatment of a rare case of unruptured right SOVA using transthoracic echocardiography, contrastive echocardiography, and transesophageal echocardiography.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Chemistry, Analytical
Shen Wang, Yingcui Bu, Xin Lu, Dandan Chen, Zhipeng Yu, Jie Zhang, Lianke Wang, Hongping Zhou
Summary: A specifically cancer cell lysosome targeted pre-photosensitizer with suitable pH-response range has been designed and applied for switch-on photodynamic therapy. The experiments on mice model showed that the pre-photosensitizer is inactive in normal tissue and active in tumor region.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Materials Science, Biomaterials
Limin Chang, Ruixue Chang, Xiaojun Liu, Xiangbo Ma, Danyang Chen, Yong Wang, Wenjuan Li, Jianglei Qin
Summary: In this study, a pectin-based self-healing hydrogel was developed with conjugated polyphosphate for effective hemostasis and wound healing. The hydrogel exhibited self-healing property and sustained release performance, leading to accelerated blood coagulation and wound repair. Moreover, it also prevented bacterial invasion.
BIOMATERIALS ADVANCES
(2022)
Article
Engineering, Electrical & Electronic
Cao Minghua, Wu Zhaoheng, Zhang Wei, Qiu Yan, Xia Jieping, Chen Dan, Wang Huiqin
Summary: In this paper, a hybrid modulated faster-than-Nyquist (PSK-PPM-FTN) rate atmospheric optical communication scheme is proposed, which combines phase-shift keying (PSK) and pulse-position modulation (PPM) to improve the bandwidth utilization and data transmission rate of the system.
LASER & OPTOELECTRONICS PROGRESS
(2022)
Article
Astronomy & Astrophysics
Homare Abe, Tomotada Akutsu, Masaki Ando, Akito Araya, Naoki Aritomi, Hideki Asada, Yoichi Aso, Sangwook Bae, Rishabh Bajpai, Kipp Cannon, Zhoujian Cao, Eleonora Capocasa, Man Leong Chan, Dan Chen, Yi-Ru Chen, Marc Eisenmann, Raffaele Flaminio, Heather K. Fong, Yuta Fujikawa, Yuya Fujimoto, I. Putu Wira Hadiputrawan, Sadakazu Haino, Wenbiao Han, Kazuhiro Hayama, Yoshiaki Himemoto, Naoatsu Hirata, Chiaki Hirose, Tsung-Chieh Ho, Bin-Hua Hsieh, He-Feng Hsieh, Chia-Hsuan Hsiung, Hsiang-Yu Huang, Panwei Huang, Yao-Chin Huang, Yun-Jing Huang, David C. Y. Hui, Kohei Inayoshi, Yuki Inoue, Yousuke Itoh, Pil-Jong Jung, Takaaki Kajita, Masahiro Kamiizumi, Nobuyuki Kanda, Takashi Kato, Chunglee Kim, Jaewan Kim, Young-Min Kim, Yuichiro Kobayashi, Kazunori Kohri, Keiko Kokeyama, Albert K. H. Kong, Naoki Koyama, Chihiro Kozakai, Jun'ya Kume, Sachiko Kuroyanagi, Kyujin Kwak, Eunsub Lee, Hyung Won Lee, Ray-Kuang Lee, Matteo Leonardi, Kwan-Lok Li, Pengbo Li, Lupin Chun-Che Lin, Chun-Yu Lin, En-Tzu Lin, Hong-Lin Lin, Guo-Chin Liu, Ling-Wei Luo, Miftahul Ma'arif, Yuta Michimura, Norikatsu Mio, Osamu Miyakawa, Kouseki Miyo, Shinji Miyoki, Nozomi Morisue, Kouji Nakamura, Hiroyuki Nakano, Masayuki Nakano, Tatsuya Narikawa, Lan Nguyen Quynh, Takumi Nishimoto, Atsushi Nishizawa, Yoshihisa Obayashi, Kwangmin Oh, Masatake Ohashi, Tomoya Ohashi, Masashi Ohkawa, Yoshihiro Okutani, Ken-ichi Oohara, Shoichi Oshino, Kuo-Chuan Pan, Alessandro Parisi, June Gyu Park, Fabian E. Pena Arellano, Surojit Saha, Kazuki Sakai, Takahiro Sawada, Yuichiro Sekiguchi, Lijing Shao, Yutaka Shikano, Hirotaka Shimizu, Katsuhiko Shimode, Hisaaki Shinkai, Ayaka Shoda, Kentaro Somiya, Inhyeok Song, Ryosuke Sugimoto, Jishnu Suresh, Takamasa Suzuki, Takanori Suzuki, Toshikazu Suzuki, Hideyuki Tagoshi, Hirotaka Takahashi, Ryutaro Takahashi, Hiroki Takeda, Mei Takeda, Atsushi Taruya, Takayuki Tomaru, Tomonobu Tomura, Lucia Trozzo, Terrence T. L. Tsang, Satoshi Tsuchida, Takuya Tsutsui, Darkhan Tuyenbayev, Nami Uchikata, Takashi Uchiyama, Tomoyuki Uehara, Koh Ueno, Takafumi Ushiba, Maurice H. P. M. van Putten, Tatsuki Washimi, Chien-Ming Wu, Hsun-Chung Wu, Tomohiro Yamada, Kazuhiro Yamamoto, Takahiro Yamamoto, Ryo Yamazaki, Shu-Wei Yeh, Jun'ichi Yokoyama, Takaaki Yokozawa, Hirotaka Yuzurihara, Simon Zeidler, Yuhang Zhao
Summary: KAGRA is a gravitational-wave detector in Japan with unique features of underground construction and cryogenic cooling. Although its sensitivity to gravitational waves is inferior to other detectors like LIGO and Virgo, further upgrades are being conducted to improve its sensitivity for the next observation run in 2022.
Review
Chemistry, Multidisciplinary
Dan Chen, Yingying Zhang, Yao Xu, Qing Nie, Zhanbin Yang, Wenyu Sheng, Guangren Qian
Summary: This review discusses the application of recycling municipal solid waste incineration (MSWI) residues in construction materials, emphasizing the potential opportunities for the construction and building industry. The paper summarizes the utilization of MSWI residues in four typical building materials and highlights the importance of proper treatment methods to improve the properties of the residues. The study concludes that recycling MSWI residues can provide significant economic and environmental benefits, although further research is needed for treatment methods of fine particles.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
