期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 82, 期 -, 页码 973-978出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2015.10.088
关键词
Ganoderma lucidum polysaccharides liposome; Peritoneal macrophages; Phagocytosis; MHC II
资金
- National Natural Science Foundation of China [31372472]
- Special Fund for Agro-scientific Research in the Public Interest [201303046, 201403051]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The activation of murine peritoneal macrophages by Ganoderma lucidum polysaccharides liposomes (GLPL) was investigated in vitro. After treatment with GLPL, the changes of the nitric oxide (NO) secretion and iNOS (inducible nitric oxide synthase) activity were evaluated. The results showed that NO production and iNOS activity of macrophages were enhanced compared to GLP and BL group. In addition, both the phagocytic activity and levels of cytokines IL-1 beta, TNF-alpha and IFN-gamma were enhanced in the peritoneal macrophages of mice by stimulation of GLPL. The expression of the major histocompatibility complex class II molecule (MHC II) on the surface of peritoneal macrophages significantly increased. These indicated that GLPL could enhance the activation of peritoneal macrophages and their potential for use as a delivery system of GLP. (C) 2015 Elsevier B.V. All rights reserved.
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