Article
Biochemistry & Molecular Biology
Naiara Dutra Barroso Gomes, Emanuel Paula Magalhaes, Lyanna Rodrigues Ribeiro, John Washington Cavalcante, Marcelo Morais Gomes Maia, Felipe Ramon Cunha da Silva, Arif Ali, Marcia Machado Marinho, Emmanuel Silva Marinho, Helcio Silva dos Santos, Alice Maria Costa Martins, Ramon Roseo Paula Pessoa Bezerra de Menezes
Summary: This study evaluated the activity of synthetic p-aminochalcones against T. cruzi and found that they have a trypanocidal effect by causing membrane damage and oxidative stress. Their mechanism of action may be related to inhibition of cruzain and TR.
BIOORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Manuel A. Llanos, Lucas N. Alberca, Salome C. Vilchez Larrea, Alejandra C. Schoijet, Guillermo D. Alonso, Carolina L. Bellera, Luciana Gavenet, Alan Talevi
Summary: Cyclic nucleotide phosphodiesterases play crucial roles in the proliferation, differentiation, and osmotic regulation of trypanosomatids. Researchers have developed a homology model of Trypanosoma cruzi PDEb1 and validated its accuracy through docking and scoring experiments using crystal structures of related enzymes. This model can be applied in virtual screening campaigns to identify novel hits and guide the rational design of potent inhibitors targeting this enzyme.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Cardiac & Cardiovascular Systems
Maria Carmo P. Nunes, Lewis F. Buss, Jose Luiz P. Silva, Larissa Natany A. Martins, Claudia Di Lorenzo Oliveira, Clareci Silva Cardoso, Bruno Oliveira de Figueiredo Brito, Ariela Mota Ferreira, Lea Campos Oliveira, Ana Luiza Bierrenbach, Fabio Fernandes, Michael P. Busch, Viviane Tiemi Hotta, Luiz Mario Baptista Martinelli, Maria Carolina F. Almeida Soeiro, Adriana Brentegani, Vera M. C. Salemi, Marcia M. Menezes, Antonio Luiz P. Ribeiro, Ester Cerdeira Sabino
Summary: This study provides a comprehensive description of the natural history of T. cruzi seropositivity in a contemporary patient population, highlighting the central importance of anti-T. cruzi antibody titer as a marker of Chagas disease activity and risk of progression.
Article
Microbiology
Sergio Castaneda, Marina Munoz, Peter J. Hotez, Maria Elena Bottazzi, Alberto E. Paniz-Mondolfi, Kathryn M. Jones, Rojelio Mejia, Cristina Poveda, Juan David Ramirez
Summary: Chagas disease is caused by Trypanosoma cruzi and has a profound impact on the gastrointestinal tract. Alterations in the gut microbiome caused by the parasite may play a crucial role in host-parasite interactions and immune responses. Understanding this interaction could provide valuable insights into the pathophysiology of the disease and the development of new treatments.
MICROBIOLOGY SPECTRUM
(2023)
Article
Chemistry, Medicinal
Rubia Castro Fernandes Melo Reis, Elda Goncalves dos Santos, Monique Dias Benedetti, Adriana Cotta Cardoso Reis, Geraldo Celio Brandao, Glenda Nicioli da Silva, Lucas Abreu Diniz, Rafaela Salgado Ferreira, Ivo Santana Caldas, Saulo Fehelberg Pinto Braga, Thiago Belarmino de Souza
Summary: A new compound, 27, has been discovered with potent anti-Trypanosoma cruzi activity, showing promise as a potential drug candidate for the treatment of Chagas disease.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Leonardo da Silva Lara, Guilherme Curty Lechuga, Lorraine Martins Rocha Orlando, Byanca Silva Ferreira, Bernardo Araujo Souto, Mauricio Silva dos Santos, Mirian Claudia de Souza Pereira
Summary: Chagas disease is a long-standing disease that primarily affects impoverished populations in Latin America. The available drugs have limited effectiveness and intense side effects. This study explores the biological activity of two new series of pyrazole-thiazoline derivatives with potential therapeutic options against Trypanosoma cruzi. These derivatives show potent activity with good oral bioavailability and low cytotoxicity, making them potential candidates for Chagas disease therapy.
Article
Microbiology
Christian Bustamante, Andres Felipe Diez-Mejia, Natalia Arbelaez, Maurilio Jose Soares, Sara M. Robledo, Rodrigo Ochoa, Ruben E. Varela-M., Marcel Marin-Villa
Summary: This study identified a potential therapeutic compound, UBMC-4, with trypanocidal activity against Chagas disease. In vitro experiments demonstrated that UBMC-4 effectively inhibited the growth of Trypanosoma cruzi at low concentrations and caused significant structural changes in the parasite cells. Furthermore, pharmacokinetic analysis in a mouse model showed that UBMC-4 was well absorbed and reached plasma concentrations higher than the effective concentration, signifying its potential as a new drug for treating Chagas disease.
Article
Infectious Diseases
A. Abras, C. Ballart, A. Fernandez-Arevalo, T. Llovet, M. Gallego, C. Munoz
Summary: The study evaluated two algorithms for the diagnosis of chronic and congenital Chagas disease, with CMIA showing potential as a single diagnostic test in non-endemic countries and the revised algorithm with the >= 6 S/CO proving to be an efficient method for chronic CD diagnosis. For infants with congenital infection, CMIA could potentially be used as a single test for screening at 10 months or earlier, but further research is needed.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Ezio R. A. de Sa, Janilson L. Souza, Rayla K. M. Costa, Romulo O. Barros, Carlos E. B. de Lima, Francisco das C. A. Lima, Ricardo M. Ramos
Summary: This study investigated the potential inhibitory activity of alkaloids from Pilocarpus microphyllus leaves against Trypanosoma cruzi, the protozoan responsible for Chagas disease. Computational methods were used to analyze the physicochemical, pharmacokinetic, and pharmacodynamic properties of these alkaloids. The results suggested that isopilosine could be a potential drug candidate for Chagas disease. The findings contribute to the search for new treatments for this neglected tropical disease.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Pharmacology & Pharmacy
Mariana C. Pagotti, Herbert J. Dias, Ana Carolina B. B. Candido, Thais A. S. Oliveira, Alexandre Borges, Nicoli D. Oliveira, Carla D. Lopes, Renato P. Orenha, Renato L. T. Parreira, Antonio E. M. Crotti, Lizandra G. Magalhaes
Summary: Chagas disease, a neglected tropical disease, affects over 8 million people. Although current therapies have limited effectiveness and high toxicity, the search for new drugs remains important. In this study, neolignans were synthesized and evaluated for their activity against Trypanosoma cruzi strains. Four neolignans demonstrated activity against the T. cruzi strain, with DBN 1 exhibiting the highest activity. In silico analysis showed that these compounds could destabilize tubulin-microtubule interactions. These compounds have potential as molecular prototypes for developing new antiparasitic drugs.
Article
Chemistry, Applied
Edward Valera-Vera, Chantal Reigada, Melisa Saye, Fabio A. Digirolamo, Facundo Galceran, Mariana R. Miranda, Claudio A. Pereira
Summary: The study showed that the anthocyanidin delphinidin inhibits the activity of Trypanosoma cruzi arginine kinase with a non-competitive mechanism. Delphinidin was found to exert trypanocidal activity with low toxicity, making it a potential candidate for the development of drugs for Chagas disease treatment.
NATURAL PRODUCT RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Johny Wysllas de Freitas Oliveira, Mariana Farias Alves da Silva, Igor Zumba Damasceno, Hugo Alexandre Oliveira Rocha, Arnobio Antonio da Silva Junior, Marcelo Sousa Silva
Summary: This study investigated the encapsulation of sodium diethyldithiocarbamate (DETC) by poly-lactic acid (PLA) in nanoparticles for the treatment of Chagas disease caused by Trypanosoma cruzi. The nanoparticles showed reduced toxicity against cells and maintained antiparasitic activity. The physical characterization of the nanoparticles demonstrated a small size and negative zeta potential. The encapsulated DETC exhibited similar efficacy against T. cruzi as the free form.
Article
Biochemistry & Molecular Biology
Natalia Lins da Silva-Gomes, Leonardo Alexandre de Souza Ruivo, Claudia Moreira, Marcelo Meuser-Batista, Cristiane Franca da Silva, Denise da Gama Jaen Batista, Stenio Fragoso, Gabriel Melo de Oliveira, Maria de Nazare Correia Soeiro, Otacilio C. Moreira
Summary: In this study, genetically modified strains of Trypanosoma cruzi were used to evaluate the role of NTPDases in parasite infectivity. The results showed that parasites overexpressing TcNTPDase-1 had higher infectivity, while hemi-knockout parasites had lower infectivity and no significant electrocardiographic changes. These findings highlight the potential of NTPDases as a therapeutic target for Chagas disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Gevanio Bezerra de Oliveira Filho, Marcos Verissimo de Oliveira Cardoso, Aline Caroline da Silva Santos, Thiago Andre Ramos dos Santos, Ana Catarina Cristovao-Silva, Laura Gonzalez Rubio, Luiz da Silva Maia Neto, Paulo Gaio Leite, Fabiana Simao Machado, Luiz Carlos Alves, Fabio Andre Brayner, Valeria Rego Alves Pereira, Ana Cristina Lima Leite
Summary: Chagas disease is causing more deaths in the Americas than any other parasitic disease and is increasingly becoming a global health problem. A novel series of 4-thiazolidinones derivatives have shown increased anti-T. cruzi activity, indicating potential for treating the disease.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Public, Environmental & Occupational Health
Jorge Vasconez-Gonzalez, Juan S. Izquierdo-Condoy, Raul Fernandez-Naranjo, Esteban Gamez-Rivera, Andrea Tello-De-la-Torre, Galo S. Guerrero-Castillo, Carlos Ruiz-Sosa, Esteban Ortiz-Prado
Summary: Chagas disease is a neglected tropical disease caused by Trypanosoma cruzi, transmitted through contact with triatomine insect feces and urine. It infects approximately 6-7 million people worldwide, causing at least 14,000 deaths annually. In Ecuador, it has been reported in 20 out of 24 provinces, with El Oro, Guayas, and Loja being the most affected.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Microbiology
Alex R. J. Lima, Christiane B. de Araujo, Saloe Bispo, Jose Patane, Ariel M. Silber, M. Carolina Elias, Julia P. C. da Cunha
Summary: This study revealed differences in nucleosome organization at strategic genomic regions among replicative and nonreplicative T. cruzi forms. The nonreplicative forms have less dynamic nucleosomes, while dynamic nucleosomes are enriched at regulatory transcription initiation regions and multigenic family members associated with infective stage and virulence factors. Genes related to DNA replication, cytokinesis, transcription and translation regulation are mainly enriched on dynamic nucleosomes.
Article
Microbiology
Mariana Galvao Ferrarini, Lindice Mitie Nisimura, Richard Marcel Bruno Moreira Girard, Mayke Bezerra Alencar, Mariana Sayuri Ishikawa Fragoso, Carlla Assis Araujo-Silva, Alan de Almeida Veiga, Ana Paula Ressetti Abud, Sheila Cristina Nardelli, Rossiane C. Vommaro, Ariel Mariano Silber, Marie France-Sagot, Andrea Rodrigues Avila
Summary: Toxoplasmosis, caused by Toxoplasma gondii, affects around 2.5 billion people globally. Current treatments have severe side effects leading to discontinuation, prompting the search for new therapies. Research shows that the anticancer drug DCA can inhibit T. gondii infection without toxicity to host cells, and identifies potential kinases that regulate parasite metabolism as targets for new therapies.
Article
Microbiology
Oriana Villafraz, Marc Biran, Erika Pineda, Nicolas Plazolles, Edern Cahoreau, Rodolpho Ornitz Oliveira Souza, Magali Thonnus, Stefan Allmann, Emmanuel Tetaud, Loic Riviere, Ariel M. Silber, Michael P. Barrett, Alena Zikova, Michael Boshart, Jean-Charles Portais, Frederic Bringaud
Summary: This study demonstrates the ability of Trypanosoma brucei to metabolize multiple metabolites, in addition to proline, in challenging environments. Tricarboxylic acid cycle intermediates, such as succinate, malate and alpha-ketoglutarate, stimulate the growth of procyclic trypanosomes, highlighting the parasite's metabolic potential beyond proline utilization. Additionally, the discovery of a previously unexplored branch of the TCA cycle in procyclic trypanosomes sheds light on the parasite's metabolism in the tsetse fly.
Article
Chemistry, Applied
Edward Valera-Vera, Chantal Reigada, Melisa Saye, Fabio A. Digirolamo, Facundo Galceran, Mariana R. Miranda, Claudio A. Pereira
Summary: The study showed that the anthocyanidin delphinidin inhibits the activity of Trypanosoma cruzi arginine kinase with a non-competitive mechanism. Delphinidin was found to exert trypanocidal activity with low toxicity, making it a potential candidate for the development of drugs for Chagas disease treatment.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Edward Augusto Valera-Vera, Juan Luis Concepcion, Ana Judith Caceres, Gonzalo Raill Acevedo, Marisa Fernandez, Yolanda Hernandez, Fabio Augusto Digirolamo, Vilma Gladys Duschak, Luciana Lia Soprano, Claudio Alejandro Pereira, Mariana Renee Miranda, Karina Andrea Gomez
Summary: The study revealed higher levels of specific anti-TcAK IgG and IgE in patients with chronic Chagas disease compared to non-infected individuals, with similarities between different clinical manifestations. It suggests that TcAK may contribute to an inefficient B cell response by biasing towards a Th2 profile, and indicates a potential allergenic response associated with T. cruzi infection.
MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Romina Fernandez Varela, Ana Laura Valino, Eman Abdelraheem, Rosario Medici, Melisa Saye, Claudio A. Pereira, Peter-Leon Hagedoorn, Ulf Hanefeld, Adolfo Iribarren, Elizabeth Lewkowicz
Summary: The utility of different variants of DERA enzyme in synthesizing drug side chains and industrial applications was analyzed. One variant was found to efficiently produce the desired products under optimized conditions and exhibited tolerance to high acetaldehyde concentrations.
Article
Genetics & Heredity
Alex Ranieri Jeronimo Lima, Herbert Guimaraes de Sousa Silva, Saloe Poubel, Juliana Nunes Roson, Loyze Paola Oliveira de Lima, Hellida Marina Costa-Silva, Camila Silva Goncalves, Pedro A. F. Galante, Fabiola Holetz, Maria Cristina Machado M. Motta, Ariel M. Silber, M. Carolina Elias, Julia Pinheiro Chagas da Cunha
Summary: This study investigated the impact of chromatin changes on the differentiation process of Trypanosoma cruzi, identifying differences in genome compartments and the regulation of tRNA loci. The results suggest a positive correlation between active chromatin and gene transcription levels, reflecting the unique gene expression regulation in trypanosomes.
EPIGENETICS & CHROMATIN
(2022)
Correction
Genetics & Heredity
Alex Ranieri Jeronimo Lima, Herbert Guimaraes de Sousa Silva, Saloe Bispo Poubel, Juliana Nunes Roson, Loyze Paola Oliveira de Lima, Hellida Marina Costa-Silva, Camila Silva Goncalves, Pedro A. F. Galante, Fabiola Holetz, Maria Cristina Machado Motta, Ariel M. Silber, M. Carolina Elias, Julia Pinheiro Chagas da Cunha
EPIGENETICS & CHROMATIN
(2022)
Article
Multidisciplinary Sciences
Fabia Tomie Tano, Gustavo Rolim Barbosa, Eloiza de Rezende, Rodolpho Ornitz Oliveira Souza, Sandra Marcia Muxel, Ariel Mariano Silber, Giuseppe Palmisano, Beatriz Simonsen Stolf
Summary: The study compared the infectivity, proteomes, and morphologies of Leishmania amazonensis PH8 and LV79 promastigotes. Results showed differences in adhesion and phagocytosis by macrophages between the two strains, as well as distinct protein profiles with proteins related to different metabolic pathways. This sheds light on metacyclogenesis in L. amazonensis and proteins important for infection by this species.
Article
Infectious Diseases
Deanna dos Santos Lima, Wandklebson Silva da Paz, Alvaro Francisco Lopes de Sousa, Denise de Andrade, Beatriz Juliana Conacci, Flavia Silva Damasceno, Marcio Bezerra-Santos
Summary: Acute diarrhea is the second leading cause of death among children in developing countries. A study conducted in the state of Alagoas, Brazil, found that it has the highest mortality rates related to diarrhea, especially in impoverished and inland areas. The study also identified a correlation between these mortality rates and socioeconomic conditions.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Article
Pharmacology & Pharmacy
Facundo Galceran, Fabio A. Digirolamo, Marcos Rengifo, Chantal Reigada, Melisa Saye, Belen J. Maciel, Ivana G. Estecho, Andrea E. Errasti, Claudio A. Pereira, Mariana R. Miranda
Summary: In this study, potential drugs for the treatment of Chagas' disease were identified using computer-assisted drug repurposing methods. NEB and TEL showed inhibitory effects on the causative agent of Chagas' disease and performed comparably to the first-line drug BZL.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Parasitology
Mariana R. Miranda, Melisa Saye, Chantal Reigada, Facundo Galceran, Marcos Rengifo, Belen J. Maciel, Fabio A. Digirolamo, Claudio A. Pereira
Summary: NDPKs have been identified as key metabolic enzymes across all organisms, maintaining nucleoside homeostasis and playing diverse roles in gene regulation, apoptosis, signal transduction, and more. Research has shown that trypanosomatid NDPKs have unique functions compared to their hosts, potentially making them attractive pharmacological targets for parasite biology and immune evasion.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)