期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 86, 期 -, 页码 425-433出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2015.12.025
关键词
Turbinaria decurrens; Neuroprotective; MPTP; Brown seaweed; Parkinson disease
资金
- Ministry of Earth science
- UGC Government of India
Fucoidan is one of the dominant sulfated polysaccharide which was extracted from the brown seaweed Turbinaria decurrens. In the behavioral study mice treated with fucoidan showed better response than the MPTP treated mice. Antioxidants and dopamine level has been increased in the fucoidan treated mice when compared to MPTP induced mice. In Immunohistochemistry, the increase of TH positive cells in the fucoidan treated group is correlated with the TH protein levels in substantia nigra and corpus striatum. The increase is greater than the content of dopamine and DOPAC, which may be explained that the dopaminergic terminals are more sensitive to MPTP toxicity and therefore are more severely damaged than the dopaminergic cell bodies. In immunoblotting TH and DAT was used, both the antibodies expression in MPTP was reduced and reversed in other groups. From the results it was conformed that the fucoidan has a neuroprotective effect without any side effects. (C) 2015 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据