Article
Cell Biology
R. A. Skolik, J. Solocinski, M. E. Konkle, N. Chakraborty, M. A. Menze
Summary: This study found that substituting glucose with galactose in the cell culture medium can shift ATP production in tumor cells from substrate-level phosphorylation to mitochondrial OXPHOS, leading to a global metabolic reorganization and restoring metabolic balance in the cells.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Oncology
Su-Jun Sun, Peng Deng, Chun-E Peng, Hai-Yu Ji, Long-Fei Mao, Li-Zeng Peng
Summary: The study found that selenium-modified chitosan (SMC) can induce apoptosis in HepG2 cells, arrest the cell cycle in the S and G2/M phases, disrupt mitochondrial membrane potential, decrease Bcl-2 expression, increase Bax, cytochrome C, cleaved caspase 9, and cleaved caspase 3 expression. Additionally, 2-DE results showed downregulation of specific proteins in HepG2 cells after SMC treatment.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Medicine, Research & Experimental
Abdulrahman L. Al-Malki, Ashraf Bakkar, Etimad A. Huwait, Elie K. Barbour, Kalid O. Abulnaja, Taha A. Kumosani, Said S. Moselhy
Summary: This study evaluated the anti-proliferative and pro-apoptotic effects of strigol/albumin/chitosan nanoparticles (S/A/CNP) on HepG2 cell line, finding that it can modulate energetic and epigenetic metabolites, making it a potential therapeutic agent for hepatocellular carcinoma.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Mahmoud H. Abu Elella, Ahmed Esmail Shalan, Magdy W. Sabaa, Riham R. Mohamed
Summary: This study demonstrated the efficacy of one-pot green biosynthesis of TMC/Ag nanocomposites as effective antimicrobial agents in food preservation. The results showed that TMC/Ag nanocomposites exhibited superior antimicrobial activity, which increased with higher concentrations of silver.
Article
Chemistry, Applied
Priyanka Sahariah, Georgia-Ioanna Kontogianni, Effie Scoulica, Olafur E. Sigurjonsson, Maria Chatzinikolaidou
Summary: In order to address the issues of antibiotic resistance and toxicity of synthetic polymers, we developed a synthetic method to create biocompatible polymers with broad spectrum antimicrobial properties. By incorporating cationic and hydrophobic functionality into N-functionalized chitosan polymers, we achieved optimal antibacterial effects against four bacterial strains. The polymer showed stronger inhibition and killing effects on Gram positive bacteria compared to Gram negative bacteria, as confirmed by growth kinetics and SEM imaging.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Miaomiao Yu, Ruili Wang, Zhiyuan Ma, Meifang Zhu
Summary: In this study, block copolymers consisting of a hydrophilic glycopolymer block and a porphyrin-containing hydrophobic block were prepared via reversible addition-fragmentation chain transfer polymerization. These polymeric photosensitizers generate singlet oxygen and show excellent photodynamic therapy (PDT) effects against HepG2 cells. By combining with the chemotherapy drug Doxorubicin (Dox), the polymeric copolymers exhibit enhanced phototoxicity, indicating the superior therapeutic benefit of the synergistic effect of PDT and chemotherapy. The galactose-containing photosensitizers exhibit a stronger intracellular uptake in HepG2 cells compared to L929 and MCF-7 cells, showing their potential for targeted cancer therapy.
Article
Polymer Science
Agnieszka Piegat, Anna Zywicka, Agata Niemczyk, Agata Goszczynska
Summary: The antibacterial activity of N,O-acylated chitosan derivative with linoleic acid was tested against Staphylococcus aureus, Escherichia coli, and Helicobacter pylori strains using various methods. The results showed that the derivative exhibited enhanced antibacterial activity and specific mucin interactions, especially against S. aureus and H. pylori. This study highlights the high potential of the derivative in antibacterial applications, particularly in the gastrointestinal tract.
Article
Biochemistry & Molecular Biology
Faika Basoglu-Uenal, Eda Becer, Hilal Kabadayi Ensarioglu, Nuray Ulusoy-Guezeldemirci, Ebru Didem Kuran, H. Seda Vatansever
Summary: Thiosemicarbazide derivative TS-1 was synthesized and evaluated for its antiproliferative potential in human hepatocellular carcinoma cells. It induced apoptosis and necroptosis in HEPG2 cells, as supported by molecular docking. The structure of TS-1 was characterized using spectroscopic methods.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Pharmacology & Pharmacy
Dazhuang Wang, Fuyao Luo, Fang He, Feifei Lu, Xu Tao, Ke Song, Jinghua Zhao, Lijiang Chen
Summary: The study synthesized a curcumol derivative CD-2e with improved bioavailability for treating liver cancer. CD-2e showed enhanced inhibition of cell proliferation and induction of apoptosis in HepG2 cells compared to curcumol, along with cell cycle arrest in S phase. Additionally, the study developed PEG-PCL-CD-2e polymersomes for improved drug delivery, which demonstrated rapid release of CD-2e and enhanced pharmacokinetic properties compared to free CD-2e.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Liuqi Shi, Zhanrong Li, Zhen Liang, Junjie Zhang, Ruixing Liu, Dandan Chu, Lei Han, Lei Zhu, Jianliang Shen, Jingguo Li
Summary: A chitosan-based platform was developed for ocular topical delivery of econazole, which effectively enhanced drug penetration and therapeutic effects while improving patient compliance. Its high structural adaptability also suggests potential benefits for other ocular anterior segment-related diseases.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Analytical
Yan Wang, Feiyang Liu, Qingyuan Yi, Mian Wang, Jianyi Wang
Summary: In this study, novel dual-targeting probes composed of galactose and morpholine were designed and synthesized for monitoring Fe3+ levels in the lysosome of hepatocyte. The probes exhibited good selectivity and sensitivities toward Fe3+, and showed favorable hepatic and lysosomal targeting effects.
Article
Chemistry, Physical
Yuxuan Zheng, Yuhua Gao, Haihua Li, Meifang Yan, Ruhui Guo, Zhenfa Liu
Summary: The research found that NCC acts as a cathodic corrosion inhibitor and NHGZ acts as a mixed corrosion inhibitor. NHGZ exhibits a corrosion rate of only 0.0254 mm/y in MWW at 40 degrees C, lower than the uninhibited sample of 0.9268 mm/y. NHGZ is able to molecularly adsorb onto the surface of carbon steel and form a stable protective inhibitor film, thereby inhibiting corrosion effectively.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Microbiology
Muhammad Hassan Sarfraz, Muhammad Zubair, Bilal Aslam, Asma Ashraf, Muhammad Hussnain Siddique, Sumreen Hayat, Jorrdy Neves Cruz, Saima Muzammil, Mohsin Khurshid, Muhammad Farrukh Sarfraz, Abeer Hashem, Turki M. Dawoud, Graciela Dolores Avila-Quezada, Elsayed Fathi Abd Allah
Summary: The aim of this study was to compare the application of chitosan, copper oxide, and chitosan-based copper oxide nanoparticles for healthcare purposes. The nanoparticles were synthesized using a green approach and characterized using various techniques. The nanoparticles showed antibacterial and antibiofilm potential against Acinetobacter baumannii isolates, as well as antioxidant and anticancer activities. This study demonstrates the potential of chitosan-based copper oxide nanoparticles in healthcare applications.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yusen Zhou, Tian Zhang, Xiaocui Wang, Wenqiang Wu, Jingjing Xing, Zuliang Li, Xin Qiao, Chunrui Zhang, Xiaohang Wang, Guangshun Wang, Wenhui Li, Shenglong Bai, Zhi Li, Yuanzhen Suo, Jiajia Wang, Yanli Niu, Junli Zhang, Chen Lan, Zhubing Hu, Baozhu Li, Xuebin Zhang, Wei Wang, David W. Galbraith, Yuhang Chen, Siyi Guo, Chun-Peng Song
Summary: The researchers identified a maize gene, BZU3, that regulates the synthesis of UDP-glucose during grass guard cell wall formation and is involved in protein glycosylation. The findings shed light on the dual role of BZU3 in controlling stomatal morphogenesis and provide insights into the mechanisms of grass stomata formation.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Applied
Wei Xia, Xiao-Yi Wei, Yuan-Yuan Xie, Tao Zhou
Summary: A novel thioether chitosan oligosaccharide (COS-All-Tio) with enhanced antioxidant and antibacterial activities was synthesized, and it showed no toxicity to cells.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Ayla Hassani, Ali Baradar Khoshfetrat, Reza Rahbarghazi, Shinji Sakai
Summary: Addition of nano-hydroxyapatite and collagen to alginate microcapsule hydrogel improved osteoblasts viability, reduced swelling and degradation ratios, and increased compressive strength. In addition, calcium deposits, increased intracellular calcium and alkaline phosphatase activity were found in the Alg-nHA-Col hydrogel.
CARBOHYDRATE POLYMERS
(2022)
Article
Chemistry, Applied
Shinji Sakai, Takashi Kotani, Ryohei Harada, Ryota Goto, Takahiro Morita, Soukaina Bouissil, Pascal Dubessay, Guillaume Pierre, Philippe Michaud, Redouan El Boutachfaiti, Masaki Nakahata, Masaru Kojima, Emmanuel Petit, Cedric Delattre
Summary: The PGU derivative developed in this study showed promising gelation ability in extrusion-based 3D bioprinting, resulting in hydrogel constructs with good shape fidelity. Both mouse fibroblasts and human hepatoma cells enclosed in the printed constructs exhibited approximately 95% viability the day after printing and maintained high viability for 11 days of study without significant decrease. These results highlight the great potential of the PGU derivative in tissue engineering, particularly as an ink component in extrusion-based 3D bioprinting.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Elham Badali, Mahshid Hosseini, Negar Varaa, Narges Mahmoodi, Arash Goodarzi, Vajihe Taghdiri Nooshabadi, Sajad Hassanzadeh, Zohreh Arabpour, Mehdi Khanmohammadi
Summary: This study successfully developed cell-laden silk fibroin-phenol (SF-Ph) microparticles using a co-flow microfluidic system. The microparticles showed high cell survival rate and facilitated cellular proliferation, demonstrating their potential in tissue engineering and regenerative medicine applications.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Seyed Ali Fatahian, Alireza Motavalizadehkakhky, Malihesadat Hosseiny, Seyed Mohammad Mahdi Nouri, Rahele Zhiani, Mojtaba Sohrabpour, Mehdi Khanmohammadi
Summary: Cell-laden filament-like hydrogels with superior mechanical properties and biocompatibility were prepared using a microfluidic system. The hybrid microfibers, composed of silk and hyaluronic acid derivatives, were fabricated in tunable size distribution and exhibited significantly higher tensile strength and maximum strain compared to single hyaluronic acid fibers. The encapsulation and crosslinking process did not affect cell viability, and the cells were able to continue growing within the fabricated tissue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Biomaterials
Shinji Sakai, Takahiro Morita
Summary: Silk fibroin (SF) is an attractive material for 3D bioprinting, and this study developed a method to bioprint low-viscosity SF solutions without additives. The printing process was cell-friendly, and the printed SF hydrogel constructs maintained high cell viability for a prolonged period of time, showcasing the potential of this technique in tissue engineering and regenerative medicine.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Engineering, Biomedical
Wildan Mubarok, Masaki Nakahata, Masaru Kojima, Shinji Sakai
Summary: Engineering the surfaces of biological organisms can introduce novel functions and enhance their native functions. Previous studies focused on unicellular organisms, but this research successfully engineered the surfaces of nematodes. By in situ hydrogelation, a hydrogel sheath with a thickness of approximately 10 μm was fabricated, providing protection and drug delivery capabilities to the nematodes.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Ryotaro Kazama, Ryuta Sato, Hiroyuki Fujiwara, Yanfei Qu, Masaki Nakahata, Masaru Kojima, Satoshi Fujita, Shinji Sakai
Summary: The Cell Dome platform allows for the encapsulation and growth of non-adherent cells in cavities, providing a convenient method for handling and evaluating these cells in various applications.
Article
Chemistry, Physical
Shintaroh Iwanaga, Yuta Hamada, Yoshinari Tsukamoto, Kenichi Arai, Taketoshi Kurooka, Shinji Sakai, Makoto Nakamura
Summary: This study aimed to fabricate mature engineered cardiac tissue using 3D bioprinting technology. A fiber-shaped scaffold with a support structure was designed and fabricated using a 3D bioprinter and cell-adhesive bio-inks. After seeding and culturing cardiomyocytes, the pre-tissue exhibited synchronous contraction and responsiveness to drugs. These results demonstrate that 3D bioprinting can effectively produce mature cultured myocardial tissue that is oriented and responsive to drugs.
Article
Polymer Science
Kelum Chamara Manoj Lakmal Elvitigala, Wildan Mubarok, Shinji Sakai
Summary: The study of how human umbilical vein endothelial cells (HUVECs) form capillary-like networks in vitro is crucial for understanding the factors affecting angiogenesis. This study investigates the behavior of HUVECs on composite hydrogels with different degrees of degradation, and finds that the stiffness and composition of the hydrogels can influence the elongation of HUVECs and their ability to form capillary-like networks.
Article
Cell Biology
Ryotaro Kazama, Satoshi Fujita, Shinji Sakai
Summary: HepG2 cells can form hemispherical cell aggregates in Cell Dome, a 3D culture system that allows the observation of cell behavior under hypoxic conditions and provides a better biological model.
Article
Biochemistry & Molecular Biology
Kotoko Furuno, Keiichiro Suzuki, Shinji Sakai
Summary: This study reports a novel approach for gene therapy and tissue regeneration using gelatin nanofibers obtained through electrospinning and subsequent horseradish peroxidase-mediated cross-linking, enabling the delivery and sustained release of pDNA.
Article
Engineering, Biomedical
Kotoko Furuno, Kelum Chamara Manoj Lakmal Elvitigala, Keiichiro Suzuki, Shinji Sakai
Summary: In this study, a localized delivery approach for AAV vectors using electrospun gelatin nanofiber mats was proposed. The mats were able to steadily release the loaded AAV vectors and transduce into cells. Attaching the mats to a target site allowed for localized gene delivery and reduced off-target distribution.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Materials Science, Biomaterials
Takashi Kotani, Wildan Mubarok, Takehito Hananouchi, Shinji Sakai
Summary: HRP-mediated extrusion bioprinting has great potential in tissue engineering. A method using alternating bioinks and support material was developed to address challenges in printing fidelity and structural integrity. The results demonstrated successful printing of tall and complex 3D constructs with high cell viability, indicating the promising application of this technique in tissue engineering.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Chemistry, Physical
Kelum Chamara Manoj Lakmal Elvitigala, Wildan Mubarok, Shinji Sakai
Summary: In this study, composite hydrogels were prepared by controlled crosslinking and degradation to fabricate muscle cell sheets. The exposure time to air containing H2O2 was adjusted to modulate the degrees of crosslinking and degradation. The results showed that the stiffness of the hydrogel increased with longer exposure time to H2O2 and mouse myoblasts cultured on a stiffer hydrogel formed longer and higher-density myotubes.
Article
Polymer Science
Wildan Mubarok, Kelum Chamara Manoj Lakmal Elvitigala, Shinji Sakai
Summary: This study investigates the impact of physicochemical properties on myogenesis in vitro by tuning the exposure time of Gelatin-Ph hydrogel to air containing H2O2. The results show that the stiffness of the hydrogel and degradation rate can be controlled by adjusting the exposure time, which influences the adhesion and myotube formation of myoblasts.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)