Article
Pharmacology & Pharmacy
Taiyue Li, Xiaoyi Yu, Xuerui Zhu, Yuanyuan Wen, Meizhen Zhu, Weiwei Cai, Bao Hou, Fei Xu, Liying Qiu
Summary: This study found that vaccarin can alleviate endothelial inflammatory injury in diabetes by mediating the miR-570-3p/HDAC1 pathway. The research provides new insights into the molecular mechanisms of diabetic endothelial dysfunction and vascular complications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiao Fu, Juan Tang, Ping Wen, Zezhi Huang, Masoud Najafi
Summary: Cancer patients undergoing radiotherapy, chemotherapy, or targeted cancer therapy are at risk of developing side effects due to the heavy production of ROS, which can lead to cellular damage and toxic release, triggering inflammatory responses. Redox reactions may play a crucial role in heart diseases.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Pharmacology & Pharmacy
Ji Hu, Ru Chen, Jie An, Yilong Wang, Minglu Liang, Kai Huang
Summary: The study demonstrates that dauricine can alleviate endothelial inflammation by suppressing the NF-κB pathway, leading to a decrease in adhesion of THP-1 cells to HUVECs and protection against acute lung injury in mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Gonzalez-Amor, Ana B. Garcia-Redondo, Inmaculada Jorge, Guillermo Zalba, Martina Becares, Maria J. Ruiz-Rodriguez, Cristina Rodriguez, Hugo Bermeo, Raquel Rodrigues-Diez, Francisco J. Rios, Augusto C. Montezano, Jose Martinez-Gonzalez, Jesus Vazquez, Juan Miguel Redondo, Rhian M. Touyz, Susana Guerra, Mercedes Salaices, Ana M. Briones
Summary: The study revealed that ISG15 plays a crucial role in vascular damage associated with hypertension by inducing oxidative stress and inflammation. The expression of ISG15 was positively correlated with high systolic and diastolic blood pressure as well as carotid intima-media thickness, while ISG15 knockout mice showed protection against hypertension and vascular damage.
CARDIOVASCULAR RESEARCH
(2022)
Review
Medicine, Research & Experimental
Alina Grylls, Karin Seidler, James Neil
Summary: High blood pressure is a significant public health challenge with recent evidence suggesting altered microbiota may contribute to hypertension by inducing metabolic endotoxemia through chronic translocation of lipopolysaccharides. Probiotic intervention targeting LPS-induced alterations in vascular endothelium shows potential for improving vasorelaxation, reducing vascular inflammation, and managing hypertension.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Oncology
George S. S. Prousi, Amogh M. M. Joshi, Varun Atti, Daniel Addison, Sherry-Ann Brown, Avirup Guha, Brijesh Patel
Summary: Cancer and cardiovascular disease, two leading causes of morbidity and mortality in the USA, share common inflammatory processes that contribute to their development and progression. Inflammatory signaling plays a critical role in both diseases, and certain chemotherapeutic agents can worsen existing cardiovascular disease or induce its presence by exacerbating inflammation. The exact mechanisms underlying these interactions remain poorly understood. Further investigation of this relationship is crucial for the development of new diagnostic and therapeutic approaches.
CURRENT ONCOLOGY REPORTS
(2023)
Article
Pharmacology & Pharmacy
Xuesong Li, Xiang Chen, Longbin Zheng, Minghong Chen, Yunjia Zhang, Ruigong Zhu, Jiajing Chen, Jiaming Gu, Quanwen Yin, Hong Jiang, Xuan Wu, Xian Ji, Xin Tang, Mengdie Dong, Qingguo Li, Yuanqing Gao, Hongshan Chen
Summary: This study reveals the activation of the non-canonical STING-PERK pathway in atherosclerosis, which increases BRD4 expression and promotes the transactivation of proinflammatory cytokines. This pathway is triggered by leaked mitochondrial DNA via interaction with oxidized mtDNA. Endothelial STING activation plays a significant role in atherosclerosis.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Cell Biology
Jing Qu, Yue Cheng, Wenchao Wu, Lixing Yuan, Xiaojing Liu
Summary: The glycocalyx plays a crucial role in inflammation and the development of vascular diseases, with endothelial dysfunction potentially leading to tissue swelling, chronic inflammation, and thrombosis. Eliminating endothelial inflammation may be a key target for treating vascular diseases. Research indicates that by disrupting the cycle of endothelial dysfunction and inflammation, the glycocalyx can help alleviate the progression of inflammation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Physiology
Qian Xu, Kunping Zhuo, Ruiping Cai, Xiaomin Su, Lu Zhang, Yueyang Liu, Lin Zhu, Fu Ren, Ming-Sheng Zhou
Summary: Research has shown that in hypertensive mice and human umbilical vein endothelial cells, YAP/TAZ activation induced by AngII may lead to endothelial dysfunction and vascular inflammation through PP2A-dependent dephosphorylation. Treatment with verteporfin improves endothelial function and reduces vascular inflammation, while LB-100 can prevent YAP/TAZ activation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xin Zhao, Jinfan Tian, Yue Liu, Zhishuai Ye, Mingyue Xu, Rongchong Huang, Xiantao Song
Summary: This study investigates the role of toll-like receptor 4-myeloid differentiation factor 88 (TLR4-Myd88) dependent caveolin-1 (Cav-1) expression modulation in coronary artery spasm (CAS) and explores the underlying pathogenic mechanisms. The findings suggest that Cav-1, upregulated by TLR4-Myd88, serves as an important modulator of CAS microenvironment establishment in vivo and in vitro, making it a potential pharmacologic target for the treatment of vasospasm via reduced endothelial cell inflammation.
VASCULAR PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anmei Shu, Qiu Du, Jing Chen, Yuyan Gao, Yihui Zhu, Gaohong Lv, Jinfu Lu, Yuping Chen, Huiqin Xu
Summary: Catalpol, isolated from Rehmannia glutinosa, shows promising effects in treating diabetic diseases. This study found that catalpol effectively ameliorates endothelial dysfunction and inflammation by suppressing the RAGE/RhoA/ROCK pathway, delaying the progression of DN.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Zhuqing Li, Qi Li, Li Wang, Chao Li, Mengping Xu, Yajun Duan, Likun Ma, Tingting Li, Qiao Chen, Yilin Wang, Yanxin Wang, Jiaxin Feng, Xuemei Yin, Xiaolin Wang, Jihong Han, Chengzhi Lu
Summary: Chronic sympathetic hyperactivity can lead to oxidative stress and inflammation in endothelial cells, contributing to atherosclerosis development. Renal denervation (RDN) may protect endothelial cells by reducing oxidative stress-induced inflammation, thus reducing atherosclerosis.
Article
Biochemistry & Molecular Biology
Kathryn Wolhuter, Stephanie M. Y. Kong, Christopher P. Stanley, Jason C. Kovacic
Summary: Coronary artery disease (CAD) is commonly treated using percutaneous coronary interventions (PCI), but PCI with stent placement can damage the endothelium. This review examines the role of endothelial-derived oxidants and the effects of altered redox signaling on endothelial dysfunction (ED). It also explores the impact of PCI and stent placement on oxidant production and discusses how recent advances aim to mitigate oxidative damage and improve outcomes.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Xuyun Liu, Jing Gao, Yizhen Yan, Eleftheria A. A. Georgiou, Jing Lou, Mengya Feng, Xing Zhang, Feng Gao, Jiankang Liu, Ioannis K. K. Kostakis, Lin Zhao
Summary: Mitochondria-targeted TPP-HT prevents lipotoxicity-induced endothelial dysfunction by enhancing mitochondrial function and redox balance through promoting FoxO1 and Nrf2 nuclear translocation.
Article
Biochemistry & Molecular Biology
Panagiotis Theofilis, Marios Sagris, Evangelos Oikonomou, Alexios S. Antonopoulos, Konstantinos Tsioufis, Dimitris Tousoulis
Summary: This article provides an overview of platelet research advancements and their importance in human health and disease. It summarizes the structural and functional characteristics of platelets and focuses on platelet activation processes. Additionally, it discusses potential molecular mechanisms involving inflammation, endothelial dysfunction, and miRs. The article also presents available antiplatelet agents and drugs currently under investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Erika Rimondi, Annalisa Marcuzzi, Fabio Casciano, Gianluca Tornese, Agnese Pellati, Barbara Toffoli, Paola Secchiero, Elisabetta Melloni
Summary: This study demonstrates that vitamin D deficiency may contribute to the formation and instability of atheromatous plaques in mice, suggesting a potential role for vitamin D in preventing or delaying atheromatous disease in cardiovascular disorders. Further research is needed to fully understand the impact of vitamin D in cardiovascular diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Giordana Feriotto, Federico Tagliati, Riccardo Giriolo, Fabio Casciano, Claudio Tabolacci, Simone Beninati, Mahmud Tareq Hassan Khan, Carlo Mischiati
Summary: Caffeic acid demonstrated anti-proliferative and apoptosis-inducing effects on chronic myeloid leukemia cells at micro-molar concentrations, by increasing the expression of cell cycle repressor genes. Additionally, it enhanced the anti-leukemic effect of imatinib, highlighting its nutraceutical potential in CML.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Davide Ferrari, Andrea la Sala, Daniela Milani, Claudio Celeghini, Fabio Casciano
Summary: Atherosclerosis is a disease characterized by cholesterol deposition in arterial walls, leading to narrowing and hardening of blood vessels. Immunomediated inflammatory response and thrombosis are major contributors to the severity of atherosclerosis. Purinergic signaling plays a crucial role in modulating immune responses and may have potential clinical significance in the treatment of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Elisabetta Melloni, Elena Marchesi, Lorenzo Preti, Fabio Casciano, Erika Rimondi, Arianna Romani, Paola Secchiero, Maria Luisa Navacchia, Daniela Perrone
Summary: Chenodeoxycholic acid and ursodeoxycholic acid were conjugated with paclitaxel to improve its ability to enter cancer cells, while exhibiting lower toxicity on healthy cells.
Article
Cell Biology
Ajay Vikram Singh, Vaisali Chandrasekar, Peter Laux, Andreas Luch, Sarada Prasad Dakua, Paolo Zamboni, Amruta Shelar, Yin Yang, Vaibhav Pandit, Veronica Tisato, Donato Gemmati
Summary: This study proposes a hybrid blood-brain barrier (BBB)-on-chip cell culture device that integrates microcontact printing and perfusion co-culture to facilitate the study of BBB function. The research reveals the biochemical regulation of BBB function by astrocytes and the geometry-force control of astrocyte-endothelial cell interactions in the BBB model.
Review
Medicine, General & Internal
Fabio Casciano, Enrico Zauli, Erika Rimondi, Marco Mura, Maurizio Previati, Massimo Busin, Giorgio Zauli
Summary: The retina requires fine-tuned vascularization for its energy supply. Diabetic retinopathy reduces the oxygen supply, leading to retinal neurodegeneration. The mTOR pathway seems to coordinate retinal neurodegeneration with various metabolic processes in diabetic retinopathy. This review discusses the normal anatomy of the retina and explores the involvement of the mTOR pathway in hyperglycemia-induced neurodegeneration.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Guendalina Montico, Francesca Mingozzi, Fabio Casciano, Giulia Protti, Laura Gornati, Erika Marzola, Giuseppe Banfi, Remo Guerrini, Paola Secchiero, Stefano Volinia, Francesca Granucci, Eva Reali
Summary: This study found clonal expansion of CCR4(+) T-CM cells in the peripheral blood and synovial fluid of patients with psoriatic arthritis, suggesting a role in the generation and spreading of autoreactive T cells to the synovioentheseal tissues.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Giada Lodi, Valentina Gentili, Fabio Casciano, Arianna Romani, Giorgio Zauli, Paola Secchiero, Enrico Zauli, Carolina Simioni, Silvia Beltrami, Mercedes Fernandez, Roberta Rizzo, Rebecca Voltan
Summary: SARS-CoV viruses downregulate antiviral defenses by manipulating p53, a key molecule for cell homeostasis and immune control. Using MDM2 inhibitors to raise p53 levels can inhibit cell cycle and virus release, as well as reduce the expression of inflammatory cytokines. Therefore, p53 and MDM2 inhibitors may be potential therapies against SARS-CoV-2.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Domenico Sergi, Enrico Zauli, Fabio Casciano, Paola Secchiero, Giorgio Zauli, Matteo Fields, Elisabetta Melloni
Summary: Hyperglycaemia and increased circulating saturated fatty acids are key metabolic features of type 2 diabetes mellitus that contribute to diabetic retinopathy pathogenesis. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can partially attenuate palmitic acid-induced lipotoxicity in an in vitro model of human retinal pigment epithelium, but further investigation is needed to determine its therapeutic potential for the treatment of diabetic retinopathy.
Review
Biochemistry & Molecular Biology
Domenico Sergi, Enrico Zauli, Veronica Tisato, Paola Secchiero, Giorgio Zauli, Carlo Cervellati
Summary: Cerebrovascular diseases and brain hypoperfusion form the basis of vascular dementia. Dyslipidemia, characterized by an increase in triglycerides and LDL-cholesterol levels and a decrease in HDL-cholesterol, promotes atherosclerosis in cardiovascular and cerebrovascular diseases. The quality and functionality of HDL-cholesterol play a significant role in cardiovascular health and cognitive function, and ceramides embedded in lipoproteins are proposed as a novel risk factor for atherosclerosis. This review discusses the role of HDL lipoprotein and ceramides in cerebrovascular diseases and their impact on vascular dementia, as well as the influence of saturated and omega-3 fatty acids on HDL levels and ceramide metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Fabio Casciano, Nicoletta Bianchi, Mirta Borin, Vittorio Vellani, Paola Secchiero, Carlo M. Bergamini, Simona Capsoni, Angela Pignatelli
Summary: We demonstrated for the first time that fluorescence intensity correlates very well with the expression of genes typical of different stages of maturation in dopaminergic neurons. We propose that the FACS method used to isolate these neurons may be used to engineer new neurons for therapeutic purposes in widespread pathologies, such as Parkinson's disease.
Review
Oncology
Fabio Casciano, Enrico Zauli, Massimo Busin, Lorenzo Caruso, Saleh AlMesfer, Samar Al-Swailem, Giorgio Zauli, Angeli Christy Yu
Summary: Ocular malignancies have significant impacts on national healthcare systems and can result in significant vision loss. The role of p53 in maintaining ocular homeostasis and its potential as a targeted therapy for managing ocular tumors are discussed in this review.
Article
Biochemistry & Molecular Biology
Giordana Feriotto, Paolo Marchetti, Riccardo Rondanin, Federico Tagliati, Serena Aguzzi, Simone Beninati, Fabio Casciano, Claudio Tabolacci, Carlo Mischiati
Summary: In this study, the bis-ketone moiety of curcumin (CUR) was replaced to obtain more stable derivatives 2 and 22. The evaluation of their chemical-physical characteristics and cell experiments showed that derivatives 2 and 22 had better bioavailability and stability than CUR, and exhibited significant cytotoxicity and pro-apoptotic effects on chronic myeloid leukemia (CML) cells. Moreover, derivative 22 was able to reverse drug resistance in CML cells resistant to imatinib (IM).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Erika Rimondi, Elisabetta Melloni, Arianna Romani, Veronica Tisato, Fabio Casciano, Gian Matteo Rigolin, Daniela Milani, Claudio Celeghini, Giorgio Zauli, Paola Secchiero, Rebecca Voltan
Summary: The study investigates the ability of ibrutinib in combination with the MDM2-inhibitor nutlin-3 to counteract the protective effect of the tumor microenvironment in B-CLL. The combined treatment significantly increases apoptosis levels, antagonizes c-MYC up-regulation, and enhances mitochondrial apoptotic pathway components, suggesting a new therapeutic strategy to overcome drug resistance in B-CLL and potentially other cancers.
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)