期刊
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
卷 18, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/ijerph182211839
关键词
Alzheimer's disease (AD); chemical exposure; pesticides; mercury (Hg); cadmium (Cd); arsenic (As); lead (Pb); HBM4EU
资金
- EU/Horizon 2020 Programme [733032 HBM4EU]
Alzheimer's disease is the most common form of dementia, possibly associated with pesticides, mercury, cadmium, arsenic, and lead, but research results are inconsistent. Despite evidence of adverse neurological effects, further research is needed to fully understand the relationship.
Alzheimer's disease (AD) is the most common form of dementia, prevalent in approximately 50-70% of the dementia cases. AD affects memory, and it is a progressive disease interfering with cognitive abilities, behaviour and functioning of the person affected. In 2015, there were 47 million people affected by dementia worldwide, and the figure was estimated to increase to 75 million in 2030 and to 132 million by 2050. In the framework of European Human Biomonitoring Initiative (HBM4EU), 18 substances or substance groups were prioritized for investigation. For each of the priority substances, a scoping document was prepared. Based on these scoping documents and complementary review of the recent literature, a scoping review of HBM4EU-priority substances which might be associated with AD was conducted. A possible association between risk of AD and pesticides was detected. For mercury (Hg), association is possible but inconsistent. Regarding cadmium (Cd) and arsenic (As), the results are inconsistent but inclined towards possible associations between the substances and the risk of disease. The evidence regarding lead (Pb) was weaker than for the other substances; however, possible associations exist. Although there is evidence of adverse neurological effects of environmental substances, more research is needed. Environmental chemical exposure and the related hazards are essential concerns for public health, and they could be preventable.
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