Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L

Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population

(2021) Lachlan Harris et al.   Cell Stem Cell

Early stem cell aging in the mature brain

(2021) Albina Ibrayeva et al.   Cell Stem Cell

Mitochondrial Proteases: Multifaceted Regulators of Mitochondrial Plasticity

(2020) Soni Deshwal et al.   Annual Review of Biochemistry

Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit

(2020) Christopher S. Morrow et al.   Cell Stem Cell

The nf-core framework for community-curated bioinformatics pipelines

(2020) Philip A. Ewels et al.   NATURE BIOTECHNOLOGY

Mitochondria-Endoplasmic Reticulum Contacts in Reactive Astrocytes Promote Vascular Remodeling

(2020) Jana Gӧbel et al.   Cell Metabolism

Aging and Rejuvenation of Neural Stem Cells and Their Niches

(2020) Paloma Navarro Negredo et al.   Cell Stem Cell

Hematopoietic Stem Cell Metabolism during Development and Aging

(2020) Ayako Nakamura-Ishizu et al.   DEVELOPMENTAL CELL

Mitochondrial dynamics in postmitotic cells regulate neurogenesis

(2020) Ryohei Iwata et al.   SCIENCE

ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence

(2020) Vijay S. Adusumilli et al.   Cell Stem Cell

Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging

(2020) Sara Bottes et al.   NATURE NEUROSCIENCE

ROMO1 is a constituent of the human presequence translocase required for YME1L protease import

(2019) Frank Richter et al.   JOURNAL OF CELL BIOLOGY

Lipid signalling drives proteolytic rewiring of mitochondria by YME1L

(2019) Thomas MacVicar et al.   NATURE

Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer

(2019) Marteinn Thor Snaebjornsson et al.   Cell Metabolism

Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis

(2019) Takashi Namba et al.   NEURON

Live imaging of neurogenesis in the adult mouse hippocampus

(2018) Gregor-Alexander Pilz et al.   SCIENCE

Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging

(2018) Dena S. Leeman et al.   SCIENCE

FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis

(2018) Iris Schäffner et al.   NEURON

Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences

(2018) Anqi Zhu et al.   BIOINFORMATICS

Loss of the mitochondrial i‐AAA protease YME1L leads to ocular dysfunction and spinal axonopathy

(2018) Hans‐Georg Sprenger et al.   EMBO Molecular Medicine

Role of Mitochondrial Metabolism in the Control of Early Lineage Progression and Aging Phenotypes in Adult Hippocampal Neurogenesis

(2017) Ruth Beckervordersandforth et al.   NEURON

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity

(2017) Marlen Knobloch et al.   Cell Reports

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

(2016) J. Tiago Gonçalves et al.   CELL

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

Benzoyl chloride derivatization with liquid chromatography–mass spectrometry for targeted metabolomics of neurochemicals in biological samples

(2016) Jenny-Marie T Wong et al.   JOURNAL OF CHROMATOGRAPHY A

The MaxQuant computational platform for mass spectrometry-based shotgun proteomics

(2016) Stefka Tyanova et al.   Nature Protocols

Inborn Errors of Long-Chain Fatty Acid β-Oxidation Link Neural Stem Cell Self-Renewal to Autism

(2016) Zhigang Xie et al.   Cell Reports

Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress

(2016) T. Kelly Rainbolt et al.   Cell Reports

Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation

(2016) Bianca Hartmann et al.   eLife

Single-Cell RNA-Seq with Waterfall Reveals Molecular Cascades underlying Adult Neurogenesis

(2015) Jaehoon Shin et al.   Cell Stem Cell

Single-Cell Transcriptomics Reveals a Population of Dormant Neural Stem Cells that Become Activated upon Brain Injury

(2015) Enric Llorens-Bobadilla et al.   Cell Stem Cell

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

(2015) Sandra Schoors et al.   NATURE

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice

(2015) T. Wai et al.   SCIENCE

Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity

(2015) Elizabeth A. Stoll et al.   STEM CELLS

Ecdysone and Mediator Change Energy Metabolism to Terminate Proliferation in Drosophila Neural Stem Cells

(2014) Catarina C.F. Homem et al.   CELL

Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation

(2014) Prashant Mishra et al.   Cell Metabolism

Thei-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

(2014) Ruchika Anand et al.   JOURNAL OF CELL BIOLOGY

One Mouse, Two Cultures: Isolation and Culture of Adult Neural Stem Cells from the Two Neurogenic Zones of Individual Mice

(2014) Tara L. Walker et al.   Jove-Journal of Visualized Experiments

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

(2012) Kati J. Ahlqvist et al.   Cell Metabolism

Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons

(2012) Seungmin Lee et al.   HUMAN MOLECULAR GENETICS

Gene Expression Profiling of Neural Stem Cells and Their Neuronal Progeny Reveals IGF2 as a Regulator of Adult Hippocampal Neurogenesis

(2012) O. Bracko et al.   JOURNAL OF NEUROSCIENCE

Metabolic control of adult neural stem cell activity by Fasn-dependent lipogenesis

(2012) Marlen Knobloch et al.   NATURE

Isolation of multipotent neural stem or progenitor cells from both the dentate gyrus and subventricular zone of a single adult mouse

(2012) Weixiang Guo et al.   Nature Protocols

In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics

(2011) Michael A. Bonaguidi et al.   CELL

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus

(2011) Juan M. Encinas et al.   Cell Stem Cell

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

(2011) F. H. Sterky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling through BMPR-IA Regulates Quiescence and Long-Term Activity of Neural Stem Cells in the Adult Hippocampus

(2010) Helena Mira et al.   Cell Stem Cell

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Sirt1 contributes critically to the redox-dependent fate of neural progenitors

(2008) Timour Prozorovski et al.   NATURE CELL BIOLOGY

Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells

(2008) Lionel M. L. Chow et al.   TRANSGENIC RESEARCH