Targeted integration of EpCAM-specific CAR in human induced pluripotent stem cells and their differentiation into NK cells

HSC and iPS cell‐derived CAR‐NK cells as reliable cell‐based therapy solutions

(2021) Jonathan Arias et al.   Stem Cells Translational Medicine

Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors

(2021) Ana L. Portillo et al.   iScience

Non‐clinical efficacy, safety, and stable clinical cell processing of iPSC‐derived anti‐GPC3 CAR‐expressing NK/ILC cells

(2020) Tatsuki Ueda et al.   CANCER SCIENCE

NK cells for cancer immunotherapy

(2020) Noriko Shimasaki et al.   NATURE REVIEWS DRUG DISCOVERY

Revisiting the Roles of Pro-Metastatic EpCAM in Cancer

(2020) M. Aiman Mohtar et al.   Biomolecules

Comprehensive Analysis of Genomic Safe Harbors as Target Sites for Stable Expression of the Heterologous Gene in HEK293 Cells

(2020) Seunghyeon Shin et al.   ACS Synthetic Biology

Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies

(2020) Keerthana Shankar et al.   Stem Cell Research & Therapy

Rosuvastatin Enhances VSV-G Lentiviral Transduction of NK Cells via Upregulation of the Low-Density Lipoprotein Receptor

(2020) Ying Gong et al.   Molecular Therapy-Methods & Clinical Development

Escape of tumor cells from the NK cell cytotoxic activity

(2020) Claudia Cantoni et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Exploring the NK cell platform for cancer immunotherapy

(2020) Jacob A. Myers et al.   Nature Reviews Clinical Oncology

Umbilical Cord Blood and iPSC-Derived Natural Killer Cells Demonstrate Key Differences in Cytotoxic Activity and KIR Profiles

(2020) Benjamin H. Goldenson et al.   Frontiers in Immunology

CAR-NK cells: A promising cellular immunotherapy for cancer

(2020) Guozhu Xie et al.   EBioMedicine

Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

(2020) Ahmet Yilmaz et al.   Journal of Hematology & Oncology

Adoptive Transfer of NKG2D CAR mRNA-Engineered Natural Killer Cells in Colorectal Cancer Patients

(2019) Lin Xiao et al.   MOLECULAR THERAPY

Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T cell

(2019) Jieming Zeng et al.   PLoS One

Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing

(2019) Tiziano Ingegnere et al.   Frontiers in Immunology

Differential transgene silencing of myeloid-specific promoters in the AAVS1 safe harbor locus of iPSC-derived myeloid cells

(2019) Denise Klatt et al.   HUMAN GENE THERAPY

CXCR1 Expression to Improve Anti-Cancer Efficacy of Intravenously Injected CAR-NK Cells in Mice with Peritoneal Xenografts

(2019) Yu Yang Ng et al.   Molecular Therapy-Oncolytics

Human iPSC-Derived Natural Killer Cells Engineered with Chimeric Antigen Receptors Enhance Anti-tumor Activity

(2018) Ye Li et al.   Cell Stem Cell

Engineering Natural Killer Cells for Cancer Immunotherapy

(2017) Katayoun Rezvani et al.   MOLECULAR THERAPY

Intraperitoneal immunotherapy with T cells stably and transiently expressing anti-EpCAM CAR in xenograft models of peritoneal carcinomatosis

(2017) Wei Xia Ang et al.   Oncotarget

Generation of “Off-the-Shelf” Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells

(2017) Jieming Zeng et al.   Stem Cell Reports

Induced Pluripotent Stem Cells Meet Genome Editing

(2016) Dirk Hockemeyer et al.   Cell Stem Cell

Engineering the AAVS1 locus for consistent and scalable transgene expression in human iPSCs and their differentiated derivatives

(2016) Fabian Oceguera-Yanez et al.   METHODS

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

Efficient Recombinase-Mediated Cassette Exchange in hPSCs to Study the Hepatocyte Lineage Reveals AAVS1 Locus-Mediated Transgene Inhibition

(2015) Laura Ordovás et al.   Stem Cell Reports

Stable Enhanced Green Fluorescent Protein Expression After Differentiation and Transplantation of Reporter Human Induced Pluripotent Stem Cells Generated by AAVS1 Transcription Activator-Like Effector Nucleases

(2014) Yongquan Luo et al.   Stem Cells Translational Medicine

Natural Killer Cells for Cancer Immunotherapy: Pluripotent Stem Cells-Derived NK Cells as an Immunotherapeutic Perspective

(2014) Cristina Eguizabal et al.   Frontiers in Immunology

Targeted transgene insertion into theAAVS1locus driven by baculoviral vector-mediated zinc finger nuclease expression in human-induced pluripotent stem cells

(2013) Felix Chang Tay et al.   JOURNAL OF GENE MEDICINE

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells

(2013) Haibao Zhu et al.   NUCLEIC ACIDS RESEARCH

Zinc Finger Nuclease-Expressing Baculoviral Vectors Mediate Targeted Genome Integration of Reprogramming Factor Genes to Facilitate the Generation of Human Induced Pluripotent Stem Cells

(2013) Rui-Zhe Phang et al.   Stem Cells Translational Medicine

Large-scale ex vivo expansion and characterization of natural killer cells for clinical applications

(2012) Natalia Lapteva et al.   CYTOTHERAPY

Quantitative Comparison of Constitutive Promoters in Human ES cells

(2010) Karin Norrman et al.   PLoS One

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

(2009) Dirk Hockemeyer et al.   NATURE BIOTECHNOLOGY

Robust, Persistent Transgene Expression in Human Embryonic Stem Cells Is Achieved with AAVS1-Targeted Integration

(2007) Joseph R. Smith et al.   STEM CELLS