Article
Clinical Neurology
Dong Ah Lee, Sungjoon Lee, Due Won Kim, Ho-Joon Lee, Kang Min Park
Summary: This study revealed significant alterations in structural covariance network and disruption of the intrahippocampal circuit in patients with transient global amnesia compared to healthy controls, which is more prominent when amnestic events recurred.
Article
Neurosciences
Francesco Bavato, Fabrizio Esposito, Dario A. Dornbierer, Niklaus Zolch, Boris B. Quednow, Philipp Staempfli, Hans-Peter Landolt, Erich Seifritz, Oliver G. Bosch
Summary: Sodium oxybate (GHB) is used clinically to promote sleep and reduce sleepiness in disorders like narcolepsy and fibromyalgia, but the neural mechanisms behind its effects are unknown.
Article
Neurosciences
Keun-Hwa Jung, Da-jin Kang, Woo-Jin Lee, Hyo-Shin Son, Sohyun Kim, Seung Wan Kang
Summary: This study aims to investigate the pathophysiological changes underlying transient global amnesia (TGA) by exploring brain activities. The results showed significant changes in EEG power spectra and network analysis in TGA patients. They exhibited a global decrease in absolute power, a decrease in alpha waves, an increase in theta waves, and atypical compensation activity. These changes were observed regardless of symptom duration, EEG timing after onset, and cytotoxic lesions on MRI. In addition, network analysis showed higher activation in TGA compared to normal controls.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Behavioral Sciences
Andrew J. Larner
Summary: Transient global amnesia (TGA) is a rare neurological disorder characterized by acute self-limited anterograde amnesia and variable retrograde amnesia. Although the clinical features, neuroimaging, prognosis, and triggering factors of TGA have been well described, the pathogenesis is currently not understood.
Article
Psychology, Clinical
Ashish K. Sahib, Joana R. Loureiro, Megha Vasavada, Cole Anderson, Antoni Kubicki, Benjamin Wade, Shantanu H. Joshi, Roger P. Woods, Eliza Congdon, Randall Espinoza, Katherine L. Narr
Summary: This study found that subanesthetic ketamine infusion therapy can modify the functional connectome in patients with major depressive disorder (MDD), making it closer to the pattern seen in healthy controls. After treatment, there was a significant decrease in functional connectivity between the cerebellum and the salience network (SN). Additionally, patients who responded to treatment showed increased functional connectivity between the cerebellum and the striatum before treatment, which decreased after treatment.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Tao Wang, Yicheng Xu, Deying Li, Wenjun Tu, Yanan Li, Shuai Miao, Jilai Li, Peifu Wang, Fei Zhao, Lingzhong Fan, Shengyuan Yu
Summary: Structural abnormalities in the hippocampus are consistently reported in TGA cases, but lesions in other brain locations can also cause TGA. The default mode network may play a role in the pathophysiology of TGA.
NEUROLOGICAL SCIENCES
(2023)
Review
Medicine, General & Internal
Marco Sparaco, Rosario Pascarella, Carmine Franco Muccio, Marialuisa Zedde
Summary: Transient global amnesia (TGA) is a clinical syndrome characterized by a temporary memory disorder with unknown etiology. Current research focuses on the vascular, epileptic, and migraine-related mechanisms, as well as the vulnerability of CA1 neurons in the hippocampus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Marco Pagani, Noemi Barsotti, Alice Bertero, Stavros Trakoshis, Laura Ulysse, Andrea Locarno, Ieva Miseviciute, Alessia De Felice, Carola Canella, Kaustubh Supekar, Alberto Galbusera, Vinod Menon, Raffaella Tonini, Gustavo Deco, Michael V. Lombardo, Massimo Pasqualetti, Alessandro Gozzi
Summary: Research indicates that synaptic pathology in Tsc2 haploinsufficient mice is associated with autism-like behavior and hyperconnectivity, which is also found in children with idiopathic ASD. These findings link mTOR-related synaptic pathology to large-scale network aberrations in autism, providing a new perspective on the mechanistic understanding of the disorder.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Renato Oliveira, Tomas Teodoro, Ines Bras Marques
Summary: Recurrence of transient global amnesia (TGA) is associated with female sex, history of depression, shorter episode duration, and hippocampal hyperintensity on brain MRI. History of depression was found to be the most important predictor of recurrence in our study.
NEUROLOGICAL SCIENCES
(2021)
Review
Medicine, General & Internal
Marco Sparaco, Rosario Pascarella, Carmine Franco Muccio, Marialuisa Zedde
Summary: Transient global amnesia (TGA) is a sudden onset memory disorder characterized by a temporary loss of memory for up to 24 hours, without any other neurological deficits. The diagnosis can be confirmed using Magnetic Resonance Imaging (MRI), although its practical utility in managing patients is still being debated.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychology, Multidisciplinary
Celine Becquet, Julien Cogez, Jacques Dayan, Pierrick Lebain, Fausto Viader, Francis Eustache, Peggy Quinette
Summary: This study investigated the impact of memory disorders on the subjective self through analyzing self-integration levels in autobiographical narratives of patients with functional amnesia and transient global amnesia (TGA). Results indicated that patients with functional amnesia tended to use general pronouns, while TGA patients preferentially used the first person. Additionally, dissociative tendencies were observed in functional amnesia patients but not in TGA patients.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Julian Santana, Carolina Garcia-Alfonso, Andrea Martinez, Andres Felipe Cardenas-Cruz, Maria Paula Aguilera-Pena, Oscar Bris-Fernandez, Alan Waich, Maria Del Mar Talero-Munoz, Juliana Coral
Summary: Transient global amnesia (TGA) is a clinical syndrome characterized by sudden anterograde amnesia without other neurological symptoms. This study identified a group of TGA patients with hippocampal ischemic lesions using brain MRI, and found that a high proportion of these patients had associated vascular risk factors. The most common risk factors were high blood pressure, carotid disease, and dyslipidemia.
NEUROLOGICAL SCIENCES
(2022)
Article
Psychiatry
Jaeun Ahn, Deokjong Lee, Kee Namkoong, Young-Chul Jung
Summary: This study aimed to examine the neurobiological alterations associated with problematic smartphone use. The results showed enhanced connectivity within and between key brain networks in problematic smartphone users, compared to healthy controls. These findings suggest a potential link between aberrant functional connectivity and problematic smartphone use.
FRONTIERS IN PSYCHIATRY
(2021)
Editorial Material
Behavioral Sciences
A. J. Larner
Summary: Recent authors claimed that Ribot described transient global amnesia in the 19th century, but a closer examination revealed discrepancies in understanding, as Ribot's references did not align with current knowledge of the condition.
Article
Pharmacology & Pharmacy
Diane Merino, Alexandre O. Gerard, Elise K. Van Obberghen, Nouha Ben Othman, Eric Ettore, Bruno Giordana, Delphine Viard, Fanny Rocher, Alexandre Destere, Michel Benoit, Milou-Daniel Drici
Summary: Transient global amnesia (TGA) cases have been reported following COVID-19 mRNA vaccination, and this study analyzed the association between TGA and COVID-19 vaccines. The analysis found significant disproportionality in TGA reports related to COVID-19 vaccines, suggesting possible underlying mechanisms such as cerebrovascular, inflammatory, or migrainous factors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Bori R. Kim, Hunki Kwon, Min Young Chun, Kee Duk Park, Soo Mee Lim, Jee Hyang Jeong, Geon Ha Kim
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Article
Clinical Neurology
Chang Hwan Oh, Jong Won Kim, Geon Ha Kim, Kyeong Ryong Lee, Dae Young Hong, Sang O. Park, Kwang Je Baek, Sin Young Kim
FRONTIERS IN NEUROLOGY
(2020)
Article
Clinical Neurology
Bori R. Kim, Ruda Lee, Nayeon Kim, Jee Hyang Jeong, Geon Ha Kim
Summary: The study found that sleep quality has a significant moderating effect on the relationship between neuroticism and frontal executive functions in older adults, indicating that interventions to improve sleep quality, such as cognitive behavioral therapy, can help reduce the risk of cognitive impairment.
BEHAVIORAL SLEEP MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hai-Jeon Yoon, Bom Sahn Kim, Jee Hyang Jeong, Geon Ha Kim, Hee Kyung Park, Min Young Chun
Summary: The study found that the asymmetric pattern of amyloid deposition differs significantly between A beta-negative normal controls and A beta(+) mild cognitive impairment (MCI), and this pattern disappears as the disease progresses.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Multidisciplinary Sciences
Yoonkyung Chang, Ho Geol Woo, Jee Hyang Jeong, Geon Ha Kim, Kee Duk Park, Tae-Jin Song
Summary: This study reveals the association between microbiota composition and poor functional outcome in stroke patients, showing significant differences in certain bacterial genera between groups with different functional outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Chang-Hyun Park, Bori R. Kim, Hee Kyung Park, Soo Mee Lim, Eunhee Kim, Jee Hyang Jeong, Geon Ha Kim
Summary: This study aimed to investigate the unique patterns of functional brain connectome in superagers and develop machine learning models to predict superagers. By analyzing resting-state functional magnetic resonance imaging data, the study found that these predictive models achieved high accuracy in predicting superagers, capturing the unique characteristics of their functional brain connectome.
Article
Chemistry, Multidisciplinary
Tae-Rim Lee, Geon-Ha Kim, Mun-Taek Choi
Summary: This study demonstrates the possibility of identifying geriatric depression and anxiety using low-cost activity trackers and minimal geriatric assessment scales.
APPLIED SCIENCES-BASEL
(2022)
Article
Medicine, General & Internal
Min Young Chun, Geon Ha Kim, Hee Kyung Park, Dong Won Yang, SangYun Kim, Seong Hye Choi, Jee Hyang Jeong
Summary: This study aimed to develop a new predictive scale for amyloid positron emission tomography (PET) positivity using easily accessible tools. The results showed that verbal and visual memory tests, medial temporal lobe atrophy, apolipoprotein E (APOE) genotype, and age were significant predictors of A beta deposition. The new predictive scale performed well in the validation cohort.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Robotics
Norina Gasteiger, Ho Seok Ahn, Christopher Lee, Jongyoon Lim, Bruce A. MacDonald, Geon Ha Kim, Elizabeth Broadbent
Summary: Participatory design involves stakeholders in the development of products to solve real-life challenges. This project developed a home-based robot for older adults with mild cognitive impairment and age-related health needs, with the involvement of experts, carers, relatives, and older adults. The robot and games were acceptable to older adults and proved useful for delivering stimulating activities and reminders for medication and health checks.
ACM TRANSACTIONS ON HUMAN-ROBOT INTERACTION
(2022)
Article
Rehabilitation
Norina Gasteiger, Ho Seok Ahn, Christine Fok, JongYoon Lim, Christopher Lee, Bruce A. MacDonald, Geon Ha Kim, Elizabeth Broadbent
Summary: This study examined the experiences of older self-supporting and community-dwelling adults using a dailycare robot in their homes, finding a high acceptance towards the robots and potential benefits. Participants suggested future functions to be personalizable to accommodate individual health needs and made recommendations for improvement.
ASSISTIVE TECHNOLOGY
(2022)
Article
Robotics
Norina Gasteiger, Ho Seok Ahn, Chiara Gasteiger, Christopher Lee, Jongyoon Lim, Christine Fok, Bruce A. Macdonald, Geon Ha Kim, Elizabeth Broadbent
Summary: Cognitive games delivered on a robot may improve cognitive functioning in older adults. Older adults generally have a positive attitude towards robot-delivered games, finding them easy to use and helpful in improving cognitive functioning. Future developments should consider the preferences and age-related health needs of older adults to enhance usability and acceptability.
ACM TRANSACTIONS ON HUMAN-ROBOT INTERACTION
(2021)
Article
Neuroimaging
Hai-Jeon Yoon, Bom Sahn Kim, Jee Hyang Jeong, Geon Ha Kim, Hee Kyung Park, Min Young Chun, Seunggyun Ha
Summary: This study investigated changes in brain perfusion and A beta burden according to the progression of Alzheimer's disease using a dual-phase 18F-florbetaben (FBB) PET protocol. The results showed significant reductions in cortical perfusion from A beta+MCI to A beta+AD groups, but no significant difference in cortical A beta depositions between these groups. Strong positive correlations were found between the R1 and eFBB images in regional and voxel-wise analyses, and both perfusion components showed significant correlations with cognitive profiles.
NEUROIMAGE-CLINICAL
(2021)
Letter
Clinical Neurology
Min Young Chun, Hee Kyung Park, Geon Ha Kim, Seung-Ah Lee, Soo-Hyun Kim, Sun Hee Sung, Yae Won Park, Jee Hyang Jeong
JOURNAL OF CLINICAL NEUROLOGY
(2020)
Correction
Clinical Neurology
Rayoung Yoo, Jiyoung Yeom, Geon Ha Kim, Hee Kyung Park, Yeonwook Kang, Jihye Hwang, Seong Hye Choi, Hae Ri Na, Soo-Jin Cho, Kyung-Ho Yu, Do Hoon Kim, Jae-Hong Lee, Jee Hyang Jeong
JOURNAL OF CLINICAL NEUROLOGY
(2020)