Article
Gastroenterology & Hepatology
Sa'ed H. Zyoud
Summary: This study provides the most up-to-date and comprehensive data on the trends in publications related to C.difficile infection. The number of published papers on this topic has significantly increased in the past decade. The United States is one of the countries with the highest publication rate. The study identifies three clusters of research areas, including illness spectrum and severity, laboratory diagnosis and characterization, and risk factors for C.difficile infection.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Pharmacology & Pharmacy
Giuseppe Esposito, Chiara Corpetti, Marcella Pesce, Luisa Seguella, Giuseppe Annunziata, Alessandro Del Re, Martina Vincenzi, Roberta Lattanzi, Jie Lu, Walter Sanseverino, Giovanni Sarnelli
Summary: The newly designed PEA-producing probiotic showed therapeutic potential in inhibiting colonic inflammation and restoring tight junction protein expression in a mouse model of CDI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Infectious Diseases
Jeremy Grossman, Jun Fan, Felicia Allard, Jane Moon, Luis A. Marcos
Summary: This article reports a fatal case of S. stercoralis hyperinfection in an immigrant from rural Ecuador and emphasizes the importance of screening for this parasite in the appropriate clinical scenarios. Various diagnostic methods are introduced to make the diagnosis of S. stercoralis more accessible to practitioners.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Mao Hagihara, Tadashi Ariyoshi, Yasutoshi Kuroki, Shuhei Eguchi, Seiya Higashi, Takeshi Mori, Tsunemasa Nonogaki, Kenta Iwasaki, Makoto Yamashita, Nobuhiro Asai, Yusuke Koizumi, Kentaro Oka, Motomichi Takahashi, Yuka Yamagishi, Hiroshige Mikamo
Summary: CBM 588 enhances the antibacterial activity against C. difficile, reduces colon epithelial damage, and improves immunity through upregulating pathogen specific immunoglobulin A and enhancing gut epithelial barrier function to protect colon tissue from CDI.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, General & Internal
Gowthami Sai Kogilathota Jagirdhar, Salim Surani
Summary: Pseudomembranous colitis is a severe inflammation of the colon caused by various factors, with Clostridium difficile being the most common cause. Symptoms include abdominal pain, diarrhea, fever, and dehydration. Other than C. difficile, other pathogens, medications, and diseases should be considered as differential diagnoses. Complications can be serious, and early diagnosis and treatment are crucial.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Gastroenterology & Hepatology
Edward V. Loftus, Daniel C. Baumgart, Krisztina Gecse, Jami A. Kinnucan, Susan B. Connelly, Leonardo Salese, Chinyu Su, Kenneth K. Kwok, John C. Woolcott, Alessandro Armuzzi
Summary: CDIs in patients with UC receiving tofacitinib were infrequent, with mild-moderate severity, and most cases resolved with treatment.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Public, Environmental & Occupational Health
Peng An Khun, Thomas V. Riley
Summary: This review provides an overview of Clostridium difficile infection (CDI) in southeast Asia, including its prevalence, detection methods, antimicrobial susceptibility profiles, and the potential significance of a One Health approach. CDI is a common cause of hospital-acquired gastroenteritis worldwide, with higher rates observed in high-income countries. Lack of knowledge and awareness about CDI, along with antimicrobial abuse and inadequate education on appropriate usage, contribute to its evolution. Underreporting of CDI rates and misuse of antimicrobial agents pose a significant threat in regions like Indochina, while C. difficile RT 017 strain is endemic in southeast Asia.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Microbiology
Peng An Khun, Long Duc Phi, Phuong Thi Pham, Ha Thi Thu Nguyen, Quyen Thi Huyen Vu, Deirdre A. Collins, Thomas V. Riley
Summary: This study investigated the prevalence, molecular epidemiology, and antimicrobial susceptibility of Clostridioides difficile in children with diarrhea in Vietnam. The results showed a high prevalence of C. difficile, but a comparatively low proportion of toxigenic strains.
Article
Microbiology
Peng An Khun, Long Duc Phi, Huong Thi Thu Bui, Deirdre A. Collins, Thomas V. Riley
Summary: This study evaluated the epidemiology, molecular characteristics, and antimicrobial susceptibility of C. difficile isolated from adults with diarrhoea in Vietnam. The overall prevalence of C. difficile was 15.1%, with 9.8% being toxigenic strains and 6.3% being non-toxigenic strains. The prevalence of multidrug resistance was 27.3%. Rating: 8 out of 10.
Article
Urology & Nephrology
Anna Giuliani, Silvia Lerco, Sabrina Milan Manani, Matteo Marcello, Ilaria Tantillo, Roberto Nicolin, Claudio Ronco, Monica Zanella
Summary: Peritoneal dialysis (PD) associated peritonitis is a common complication leading to discontinuation of PD. Clostridium difficile colitis is a frequent healthcare-associated infection in patients with end-stage kidney disease. PD patients with Clostridium difficile infection (CDI) present a challenging scenario for antibiotic treatment strategy as broad-spectrum antibiotics may worsen CDI-related colitis, while discontinuation of antibiotic therapy may worsen peritonitis.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Critical Care Medicine
Christian A. Gonzalez, Noelle L. Van Rysselberghe, Clayton Maschhoff, Michael J. Gardner
Summary: This study utilized a large national database to investigate the incidence and risk factors of Clostridium difficile (C. diff) infection in patients with lower extremity fractures. The results showed that C. diff infection was associated with increased mortality, readmission, and length of hospital stay compared to patients without C. diff infection.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Biochemistry & Molecular Biology
Tadakuni Monma, Junichi Iwamoto, Akira Honda, Hajime Ueda, Fumio Kakizaki, Shoichiro Yara, Teruo Miyazaki, Tadashi Ikegami
Summary: The ratio of secondary bile acids in serum can serve as a biomarker for predicting susceptibility to Clostridium difficile infection, with levels below a certain threshold indicating a higher risk of CDI.
Article
Pediatrics
Felix Orelaru, Patrick Karabon, Nathan Novotny, Begum Akay, Pavan Brahmamdam
Summary: This study found that Clostridium difficile infection is a rare but impactful complication of pediatric appendicitis, associated with greater disease severity. Proper antibiotic stewardship could minimize the risk of C. difficile in pediatric appendicitis.
PEDIATRIC SURGERY INTERNATIONAL
(2021)
Review
Health Care Sciences & Services
Elena Iana, Catalin Boboc, Andreea Gabriela Vlad, Maria Teodora Cosoreanu, Malina Anghel, Anca Andreea Boboc, Andreea Ioan, Mara Ioana Ionescu, Liana Gavriliu, Felicia Galos
Summary: Children with inflammatory bowel disease are more susceptible to Clostridium difficile infection, with ulcerative colitis patients being more affected than Crohn's disease patients. Managing pediatric patients with both IBD and CDI is challenging and requires a multidisciplinary approach. Treatment for underlying IBD may need to be escalated after CDI treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Kazutaka Fukushima, Ryota Inokuchi, Ichiro Hirayama, Takahiro Hiruma, Kent Doi
Summary: Early diagnosis and conservative antibiotic therapy are crucial for saving fulminant CDI patients who are not eligible for surgery due to severe complicating conditions.
CLINICAL CASE REPORTS
(2021)
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)