Article
Multidisciplinary Sciences
Lluis Masana, Eudald Correig, Daiana Ibarretxe, Eva Anoro, Juan Antonio Arroyo, Carlos Jerico, Carolina Guerrero, Marcel la Miret, Silvia Naf, Anna Pardo, Veronica Perea, Rosa Perez-Bernalte, Nuria Plana, Rafael Ramirez-Montesinos, Meritxell Royuela, Cristina Soler, Maria Urquizu-Padilla, Alberto Zamora, Juan Pedro-Botet
Summary: The presence of atherogenic dyslipidaemia during COVID-19 infection is strongly associated with a worse prognosis. Low HDL cholesterol and high triglyceride concentrations, either before or during hospitalization, are strong predictors of a severe course of the disease. Lipid profiles can be considered as sensitive markers of inflammation in patients with COVID-19 and should be measured.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Sanna Kuusisto, Minna K. Karjalainen, Therese Tillin, Antti J. Kangas, Michael Holmes, Mika Kahonen, Terho Lehtimaki, Jorma Viikari, Markus Perola, Nishi Chaturvedi, Veikko Salomaa, Olli T. Raitakari, Marjo-Riitta Jarvelin, Johannes Kettunen, Mika Ala-Korpela
Summary: The association between HDL-CEC and CHD is inconsistent, and the genetic architecture of HDL-CEC is limited. In contrast to HDL-C, apolipoprotein A-I, and most HDL subclass particle concentrations, HDL-CEC is not unequivocally associated with CHD.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Fatemeh Koohi, Davood Khalili, Mohammad Ali Mansournia, Farzad Hadaegh, Hamid Soori
Summary: The study identified seven distinct multi-trajectories of blood lipid levels and found that individuals with rising triglyceride levels over time, even with optimal LDL-C levels, faced a significantly increased risk of cardiovascular disease. Despite the decline in LDL-C levels, there remained a considerable residual risk for CVD, emphasizing the importance of monitoring and potentially lowering triglyceride concentrations to reduce this risk.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Ae-Wha Ha, Woo-Kyoung Kim, Sun-Hyo Kim
Summary: This study examines the relationship between cow's milk intake and coronary heart disease (CHD) risk in postmenopausal women. The findings suggest that postmenopausal women who consume cow's milk frequently have a better nutritional status, higher HDL levels, and a lower level of CHD risk indicators, contributing to decreased CHD risk.
Article
Clinical Neurology
Zhirong Yang, Duncan Edwards, Stephen Burgess, Carol Brayne, Jonathan Mant
Summary: This study investigated the potential associations between blood LDL-C, HDL-C, and triglycerides and post-stroke dementia. The results showed that higher LDL-C levels were associated with an increased risk of dementia, while lower triglyceride levels were associated with a decreased risk. There was no association between HDL-C levels and dementia.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Endocrinology & Metabolism
Xiaoyu Wang, Chenhao Zhao, Hongliang Feng, Guohua Li, Lei He, Lulu Yang, Yan Liang, Xiao Tan, Yanmin Xu, Ruixiang Cui, Yujing Sun, Sheng Guo, Guoan Zhao, Jihui Zhang, Sizhi Ai
Summary: This study finds that more frequent insomnia symptoms are significantly associated with insulin resistance (IR) and its related traits. These findings suggest that insomnia symptoms can serve as a promising target for improving IR and preventing type 2 diabetes (T2D).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Jeremy Yuvaraj, Mourushi Isa, Zhu Chung Che, Egynne Lim, Nitesh Nerlekar, Stephen J. Nicholls, Sujith Seneviratne, Andrew Lin, Damini Dey, Dennis T. L. Wong
Summary: This study found an association between atherogenic dyslipidaemia and cardiac adipose tissue parameters, particularly an increased volume of epicardial adipose tissue, in patients with coronary artery disease. Atherogenic index of plasma was also associated with type II diabetes, male sex, and coronary artery calcification. These findings suggest that atherogenic dyslipidaemia may contribute to adverse changes in adipose tissue, increasing the risk of coronary artery disease.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Paul F. Jacques, Gail Rogers, Jodi Dunmeyer Stookey, Erica T. Perrier
Summary: The study findings indicate a consistent association between water intake and hydration status with circulating lipid concentrations in older adults. Inadequate water intake and underhydration may lead to higher cardiometabolic risk.
JOURNAL OF NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Nicoletta Di Giorgi, Elena Michelucci, Jeff M. Smit, Arthur J. H. A. Scholte, Mohammed El Mahdiui, Juhani Knuuti, Ronny R. Buechel, Anna Teresinska, Maria N. Pizzi, Albert Roque, Rosa Poddighe, Oberdan Parodi, Gualtiero Pelosi, Chiara Caselli, Danilo Neglia, Silvia Rocchiccioli
Summary: This study found that in patients with chronic coronary syndrome, a high TG/HDL-C ratio is associated with a specific pattern of altered lipids and higher coronary CTA risk score. These results suggest the presence of a specific lipidomic signature in stable CCS patients, indicating potential molecular pathways of residual CAD risk not addressed by current optimal medical treatments.
Review
Biochemistry & Molecular Biology
Saeed Aslani, Bahman Razi, Danyal Imani, Keyhan Mohammadi, Tannaz Jamialahmadi, Zeljko Reiner, Amirhossein Sahebkar
Summary: A systematic review and meta-analysis showed that statin therapy effectively lowered levels of total cholesterol, LDL-C, and TG, and increased levels of HDL-C in patients with different CVDs.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Pal Maurovich-Horvat, Maria Bosserdt, Klaus F. Kofoed, Nina Rieckmann, Theodora Benedek, Patrick Donnelly, Jose Rodriguez-Palomares, Andrejs Erglis, Cyril Stechovsk, Gintare Sakalyte, Nada Cemerlic Adic, Matthias Gutberlet, Jonathan D. Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kepka, Radosav Vidakovic, Marco Francone, Malgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schroder, Colin Berry, Luca Saba, Balazs Ruzsics, Christine Kubiak, Inaki Gutierrez-Ibarluzea, Kristian Schultz Hansen, Jacqueline Muller-Nordhorn, Bela Merkely, Andreas D. Knudsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtech Suchanek, Laura Zajanckauskiene, Flip Adic, Michael Woinke, Mark Hensey, Inigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandar N. Neskovic, Massimo Mancone, Gudrun Feuchtner, Donata Kugrnierz, Mikko Pietila, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Gildo Matta, Michael Fisher, Balint Szilveszter, Linnea Larsen, Mihaela Ratiu, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Zsofia D. Drobni, Birgit Jurlander, Ioana Rodean, Susan Regan, Hug Cuellar Calabria, Melinda Boussoussou, Thomas Engstrom, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Melanie Estrella, Peter Martus, Marc Dewey
Summary: This study compared the effectiveness of CT and ICA in diagnosing obstructive CAD. The results showed that among patients with stable chest pain and intermediate pretest probability of CAD, the risk of major adverse cardiovascular events was similar between the CT group and the ICA group. However, the frequency of major procedure-related complications was lower in the CT group.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Pik-Fang Kho, Frederic Amant, Daniela Annibali, Katie Ashton, John Attia, Paul L. Auer, Matthias W. Beckmann, Amanda Black, Louise Brinton, Daniel D. Buchanan, Stephen J. Chanock, Chu Chen, Maxine M. Chen, Timothy H. T. Cheng, Linda S. Cook, Marta Crous-Bous, Kamila Czene, Immaculata De Vivo, Joe Dennis, Thilo Doerk, Sean C. Dowdy, Alison M. Dunning, Matthias Duerst, Douglas F. Easton, Arif B. Ekici, Peter A. Fasching, Brooke L. Fridley, Christine M. Friedenreich, Montserrat Garcia-Closas, Mia M. Gaudet, Graham G. Giles, Ellen L. Goode, Maggie Gorman, Christopher A. Haiman, Per Hall, Susan E. Hankinson, Alexander Hein, Peter Hillemanns, Shirley Hodgson, Erling A. Hoivik, Elizabeth G. Holliday, David J. Hunter, Angela Jones, Peter Kraft, Camilla Krakstad, Diether Lambrechts, Loic Le Marchand, Xiaolin Liang, Annika Lindblom, Jolanta Lissowska, Jirong Long, Lingeng Lu, Anthony M. Magliocco, Lynn Martin, Mark McEvoy, Roger L. Milne, Miriam Mints, Rami Nassir, Geoffrey Otton, Claire Palles, Loreall Pooler, Tony Proietto, Timothy R. Rebbeck, Stefan P. Renner, Harvey A. Risch, Matthias Ruebner, Ingo Runnebaum, Carlotta Sacerdote, Gloria E. Sarto, Fredrick Schumacher, Rodney J. Scott, V. Wendy Setiawan, Mitul Shah, Xin Sheng, Xiao-Ou Shu, Melissa C. Southey, Emma Tham, Ian Tomlinson, Jone Trovik, Constance Turman, Jonathan P. Tyrer, David van den Berg, Zhaoming Wang, Nicolas Wentzensen, Lucy Xia, Yong-Bing Xiang, Hannah P. Yang, Herbert Yu, Wei Zheng, Penelope M. Webb, Deborah J. Thompson, Amanda B. Spurdle, Dylan M. Glubb, Tracy A. O'Mara
Summary: This study used Mendelian randomization analysis to investigate the relationship between blood lipids and endometrial cancer risk. Genetically elevated LDL cholesterol levels were associated with reduced risk of endometrial cancer, while higher predicted HDL cholesterol levels were linked to increased risk of non-endometrioid endometrial cancer. Obesity may influence these associations, but triglycerides showed no evidence of involvement in endometrial cancer development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Obstetrics & Gynecology
Maria C. Adank, Anja K. Johansen, Laura Benschop, Sophia P. Van Streun, Anna M. Smak Gregoor, Linn K. L. Oyri, Monique T. Mulder, Eric A. P. Steegers, Kirsten B. Holven, Jeanine E. Roeters van Lennep
Summary: Maternal lipid levels in early pregnancy are positively associated with childhood lipid levels in offspring, independent of maternal BMI and diet. This suggests that gestational lipid levels can be used as an early predictor of children's long-term health.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Review
Medicine, General & Internal
Pier Luigi Temporelli, Marcello Arca, Laura D'Erasmo, Raffaele De Caterina
Summary: Hyperlipidemia is a significant risk factor for coronary heart disease, but its relationship to stroke has been less clear. Recent data demonstrate the positive impact of cholesterol-lowering on stroke, while also dispelling concerns about increased risk of hemorrhagic stroke. Despite guidelines recommending aggressive lipid-lowering therapy for at-risk patients, secondary prevention patients often do not receive adequate treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Susana Cararo Confortin, Liliana Yanet Gomez Aristizabal, Elma Izze da Silva Magalhaes, Aline Rodrigues Barbosa, Cecilia Claudia Costa Ribeiro, Rosangela Fernandes Lucena Batista, Antonio Augusto Moura da Silva
Summary: There is no association between sleep duration and cardiometabolic risk factors in adolescents.
Review
Biochemistry & Molecular Biology
Rosetta Ragusa, Silvia Masotti, Veronica Musetti, Silvia Rocchiccioli, Concetta Prontera, Marco Perrone, Claudio Passino, Aldo Clerico, Chiara Caselli
Summary: Cardiac troponins are key elements in the regulation of cardiac excitation-contraction coupling and can be used as biomarkers of acute myocardial infarction. With the use of high sensitivity immunoassay tests, they can also be used as biomarkers for other cardiac conditions. This review discusses the mechanisms of cardiac troponin release in the blood and its potential as a biomarker for cardiac adverse events.
Article
Cardiac & Cardiovascular Systems
Jurrien H. Kuneman, Sophie E. van Rosendael, Pieter van der Bijl, Alexander R. van Rosendael, Pieter H. Kitslaar, Johan H. C. Reiber, J. Wouter Jukema, Martin B. Leon, Nina Ajmone Marsan, Juhani Knuuti, Jeroen J. Bax
Summary: This study compared the pericoronary adipose tissue (PCAT) attenuation between acute coronary syndrome and stable coronary artery disease patients. The results showed that the PCAT attenuation in culprit lesion precursors of acute coronary syndrome patients was significantly higher than nonculprit lesions and lesions of stable coronary artery disease patients. Therefore, PCAT attenuation may be a novel marker for identifying high-risk plaques.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Ruurt Jukema, Teemu Maaniitty, Pepijn van Diemen, Hans Berkhof, Pieter G. Raijmakers, Ralf Sprengers, R. Nils Planken, Paul Knaapen, Antti Saraste, Ibrahim Danad, Juhani Knuuti
Summary: This study aimed to determine the warranty period after coronary CTA and the additional value of PET. Patients with suspected but not previously diagnosed CAD were categorized based on coronary CTA and the warranty period varied from 5 to 10 years depending on the CAD severity and myocardial blood flow status. Normal PET yielded a 2-year longer warranty period in patients with obstructive CAD.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Letter
Medicine, General & Internal
Chiara Caselli, Rosetta Ragusa, Riccardo Liga, Concetta Prontera, Alessia Gimelli, Arthur Scholte, Juhani Knuuti, Aldo Clerico, Danilo Neglia
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Sport Sciences
Jooa Norha, Tanja Sjoros, Taru Garthwaite, Saara Laine, Maria Saarenhovi, Petri Kallio, Kirsi Laitinen, Noora Houttu, Henri Vaha-Ypya, Harri Sievanen, Eliisa Loyttyniemi, Tommi Vasankari, Juhani Knuuti, Kari K. Kalliokoski, Ilkka H. A. Heinonen
Summary: A study on adults with metabolic syndrome found that reducing sedentary behavior without adding exercise training did not significantly improve maximal oxygen uptake (VO2max). However, increasing daily step count may increase VO2max.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas H. Schindler, William F. Fearon, Matthieu Pelletier-Galarneau, Giuseppe Ambrosio, Udo Sechtem, Terrence D. Ruddy, Krishna K. Patel, Deepak L. Bhatt, Timothy M. Bateman, Henry Gewirtz, Jamshid Shirani, Juhani Knuuti, Robert J. Gropler, Panithaya Chareonthaitawee, Riemer H. J. A. Slart, Stephan Windecker, Philipp A. Kaufmann, Maria R. Abraham, Viviany R. Taqueti, Thomas J. Ford, Paolo G. Camici, Heinrich R. Schelbert, Vasken Dilsizian
Summary: Diagnosing angina pectoris and dyspnea in patients with normal or nonobstructive coronary vessels is challenging. Invasive coronary angiography can identify nonobstructive coronary artery disease, but coronary microvascular dysfunction may actually be the cause of symptoms. Positron emission tomography (PET) allows noninvasive detection and delineation of coronary microvascular dysfunction by quantifying myocardial blood flow at rest and during vasodilation. Individualized or intensified medical therapies may improve symptoms, quality of life, and outcomes. Standardized diagnosis and reporting criteria for ischemic symptoms caused by coronary microvascular dysfunction are crucial for treatment decisions. A consensus document proposes standardized diagnosis, nomenclature, and reporting criteria for coronary microvascular dysfunction. It aims to provide an overview of its pathophysiology, assessment, and classification, which are essential for diagnosis, patient care, and clinical trials. (J Am Coll Cardiol Img 2023;16:536-548) (c) 2023 by the American College of Cardiology Foundation.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Arghavan Jahandideh, Jenni Virta, Xiang-Guo Li, Heidi Liljenback, Olli Moisio, Jesse Ponkamo, Noora Rajala, Marion Alix, Jukka Lehtonen, Mikko I. Mayranpaa, Tiina A. Salminen, Juhani Knuuti, Sirpa Jalkanen, Antti Saraste, Anne Roivainen
Summary: This study successfully demonstrated the feasibility of using [Ga-68]Ga-DOTA-Siglec-9 PET imaging to detect myocardial lesions in rats with autoimmune myocarditis, suggesting its potential as a novel technique.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jamshid Maddahi, Denis Agostini, Timothy M. Bateman, Jeroen J. Bax, Rob S. B. Beanlands, Daniel S. Berman, Sharmila Dorbala, Ernest V. Garcia, James Feldman, Gary V. Heller, Juhani M. Knuuti, Pedro Martinez-Clark, Matthieu Pelletier-Galarneau, Benjamin Shepple, Nagara Tamaki, Francois Tranquart, James E. Udelson
Summary: This study demonstrates that Flurpiridaz F-18 is a novel PET tracer with high diagnostic efficacy and safety for detecting coronary artery disease. It has higher sensitivity and specificity compared to traditional SPECT technique, especially in women and obese patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Antonella Meloni, Filippo Cademartiri, Vicenzo Positano, Simona Celi, Sergio Berti, Alberto Clemente, Ludovico La Grutta, Luca Saba, Eduardo Bossone, Carlo Cavaliere, Bruna Punzo, Erica Maffei
Summary: Photon-counting computed tomography (PCCT) is an emerging technology that offers several advantages over conventional CT, including improved spatial resolution and signal behavior, reduced noise and artifacts, decreased radiation dose, and enhanced material discrimination. This review highlights the potential diagnostic capabilities of PCCT in cardiovascular applications, such as detection of coronary artery calcifications and evaluation of coronary plaque extent and composition.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Takeru Nabeta, Maria Chiara Meucci, Jos J. M. Westenberg, Johan H. C. Reiber, Juhani Knuuti, Pieter van der Bijl, Nina Ajmone Marsan, Jeroen J. J. Bax
Summary: The inward displacement of the left ventricle, measured through cardiac magnetic resonance imaging, can independently predict the prognosis of patients with ischemic heart disease and prior myocardial infarction, and provides additional prognostic value in addition to left ventricular ejection fraction and global radial strain.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick W. Serruys, Nozomi Kotoku, Bjarne L. Norgaard, Scot Garg, Koen Nieman, Marc R. Dweck, Jeroen J. Bax, Juhani Knuuti, Jagat Narula, Divaka Perera, Charles A. Taylor, Jonathon A. Leipsic, Edward D. Nicol, Nicolo Piazza, Carl J. Schultz, Kakuya Kitagawa, Bernard De Bruyne, Carlos Collet, Kaoru Tanaka, Saima Mushtaq, Marta Belmonte, Darius Dudek, Adriana Zlahoda-Huzior, Shengxian Tu, William Wijns, Faisal Sharif, Matthew J. Budoff, Johan de Mey, Daniele Andreini, Yoshinobu Onuma
Summary: Coronary computed tomographic angiography (CCTA) has become the preferred investigation for determining the presence and haemodynamic significance of coronary artery disease. It can rule out atherosclerosis or detect subclinical plaque in patients without significant epicardial obstruction, and provide risk classification. For ischaemic non-obstructive coronary arteries, non-invasive imaging, including CCTA, is also expected. In patients with significant epicardial obstruction, CCTA can assist in planning revascularisation by determining disease complexity, vessel size, lesion length, tissue composition of the atherosclerotic plaque, and the best fluoroscopic viewing angle.
Article
Radiology, Nuclear Medicine & Medical Imaging
Oona Rainio, Chunlei Han, Jarmo Teuho, Sergey V. Nesterov, Vesa Oikonen, Sauli Piirola, Timo Laitinen, Marko Tattalainen, Juhani Knuuti, Riku Klen
Summary: Carimas is a versatile tool for processing medical imaging data, allowing visualization, analysis, and modeling of various medical images in research. Originally designed for positron emission tomography data, it has expanded to include other tomography imaging modalities like computed tomography and magnetic resonance imaging. Carimas excels in analyzing three- and four-dimensional image data and creating polar maps for cardiac perfusion modeling.
JOURNAL OF DIGITAL IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahmoud Mohamed, Maria Bosserdt, Viktoria Wieske, Benjamin Dubourg, Hatem Alkadhi, Mario J. Garcia, Sebastian Leschka, Elke Zimmermann, Abbas A. Shabestari, Bjarne L. Norgaard, Matthijs F. L. Meijs, Kristian A. Ovrehus, Axel C. P. Diederichsen, Juhani Knuuti, Bjrn A. Halvorsen, Vladymir Mendoza-Rodriguez, Yung-Liang Wan, Nuno Bettencourt, Eugenio Martuscelli, Ronny R. Buechel, Hans Mickley, Kai Sun, Simone Muraglia, Philipp A. Kaufmann, Bernhard A. Herzog, Jean-Claude Tardif, Georg M. Schuetz, Michael Laule, David E. Newby, Stephan Achenbach, Matthew Budoff, Robert Haase, Federico Biavati, Aldo Vasquez Mezquita, Peter Schlattmann, Marc Dewey
Summary: Combining coronary computed tomography angiography (CCTA) with coronary artery calcium (CAC) score can significantly improve the diagnosis of coronary artery disease (CAD). The addition of CAC score is particularly beneficial when CCTA alone is inconclusive.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Haitham Ballo, Fatma Doghman, Juha Hartikainen, Antti Saraste, Juhani Knuuti
Summary: This meta-analysis evaluated the diagnostic accuracy of 2DSTE strain in detecting myocardial viability at rest and during low-dose dobutamine stress. The results showed that LS and CS during LDD stress accurately identify reversible ischemic myocardial dysfunction in patients with chronic ischemic LV dysfunction or after MI. LS and CS had lower sensitivity and specificity at rest compared to LDD stress.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Jussi Schultz, Inge J. van den Hoogen, Jurrien H. Kuneman, Michiel A. de Graaf, Vasileios Kamperidis, Alexander Broersen, J. Wouter Jukema, Antonis Sakellarios, Sotirios Nikopoulos, Konstantina Tsarapatsani, Katerina Naka, Lampros Michalis, Dimitrios Fotiadis, Teemu Maaniitty, Antti Saraste, Jeroen J. Bax, Juhani Knuuti
Summary: This study evaluated CCTA-based ESS values in coronary arteries without atherosclerosis and identified factors affecting ESS values. The findings showed that ESS was highest in the left anterior descending artery and lower in men compared to women, even after adjusting for lumen diameter. ESS values were also highest in small segments and had a correlation with the distance from the ostium.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)