Article
Pharmacology & Pharmacy
Jiang-nan Sun, Xiao-yi Yu, Bao Hou, Min Ai, Meng-ting Qi, Xin-yu Ma, Ming-jie Cai, Min Gao, Wei-wei Cai, Lu-lu Ni, Fei Xu, Yue-tao Zhou, Li-ying Qiu
Summary: Vaccarin, the main active component in traditional Chinese medicine Vaccaria, showed enhanced intestinal barrier function in T2DM mice by modulating gut microbiota and inhibiting the ERK/MLCK signaling pathway, resulting in anti-inflammatory effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Sylvia Riedel, Carmen Pheiffer, Rabia Johnson, Johan Louw, Christo J. F. Muller
Summary: This review highlights the specific roles of the intestinal immune system and intestinal epithelial cells (IECs) in obesity and type 2 diabetes (T2D). Innate chemokine signaling, eosinophils, immunoglobulin A (IgA), T helper 17 cells and their cytokines are associated with obesity and/or dysregulated glucose homeostasis. IECs act as critical modulators of obesity and glucose homeostasis through their effect on lipopolysaccharide (LPS) signaling and decontamination, and they create a link between microbial metabolites and whole-body metabolic function.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yaping Liu, Ze Xu, Haoyue Huang, Yuan Xue, Dongdong Zhang, Yujing Zhang, Wenjie Li, Xing Li
Summary: Fucoidan has the potential to prevent type 2 diabetes by improving intestinal barrier and inflammation, and regulating glucose metabolism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Qi Qin, Yan Chen, Yongbo Li, Jing Wei, Xiaoting Zhou, Fuyin Le, Hong Hu, Tingtao Chen
Summary: The protein BefA shows significant hypoglycemic effects in a T1DM model by promoting beta cell proliferation and regulating the intestinal microbiota through increasing beneficial bacterial abundance and decreasing opportunistic pathogens. The study provides insight into the therapeutic potential of BefA protein in treating type 1 diabetes mellitus.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ling Su, Chuanxin Xin, Jintao Yang, Liran Dong, Heriban Mei, Xiaojing Dai, Qi Wang
Summary: This study investigated the protective effect and mechanism of a polysaccharide from Inonotus obliquus (IN) on type 2 diabetes mellitus. IN repaired the intestinal barrier, alleviated pathological damage, and suppressed the production of proinflammatory cytokines, making it a potential novel drug candidate for type 2 diabetes mellitus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyu Chen, Hongyuan Zhao, Yajun Lu, Huawei Liu, Fanqiang Meng, Zhaoxin Lu, Yingjian Lu
Summary: Surfactin from Bacillus amyloliquefaciens fmb50 was found to ameliorate pancreatic and colon inflammation, oxidative stress, and endoplasmic reticulum stress induced by a high-fat diet/streptozotocin in mice with type 2 diabetes. It improved glucose metabolism by activating the PI3K/Akt signaling pathway, protected islets beta-cell, enhanced insulin secretion, and mitigated pancreas dysfunction. Surfactin also increased the levels of tight junction proteins in the colon and showed potential for early intervention in preventing the development of type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Environmental Sciences
Zhuizui Huang, You Weng, Qichen Shen, Yao Zhao, Yuanxiang Jin
Summary: Studies have shown that exposure to microplastics could cause oxidative damage and inflammation in the gut, as well as the destruction of the gut epithelium, reduction of the mucus layer, microbial disorders, and immune cell toxicity. While there are few reports directly related to humans, exposure to microplastics may lead to disturbances of the intestinal microenvironment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Pharmacology & Pharmacy
Jiemei Chen, Mingchao Wang, Peng Zhang, Hui Li, Kai Qu, Ruiming Xu, Na Guo, Haibo Zhu
Summary: Cordycepin has been found to alleviate metabolic inflammation and improve obesity-related symptoms through regulating intestinal barrier function and intestinal flora.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Microbiology
Guangmang Liu, Jiajia Lu, Weixiao Sun, Gang Jia, Hua Zhao, Xiaoling Chen, In Ho Kim, Ruinan Zhang, Jing Wang
Summary: This study aimed to investigate the effect of tryptophan (Trp) on intestinal barrier function, inflammation, antioxidant status, and microbiota in LPS-challenged piglets. The results showed that Trp supplementation improved the composition of the gut microbiota, enhanced the synthesis of short chain fatty acids, reduced inflammation, increased antioxidant capacity, and improved intestinal barrier function.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Yanfei Zheng, Zengliang Zhang, Ping Tang, Yuqi Wu, Anqi Zhang, Delong Li, Chong-Zhi Wang, Jin-Yi Wan, Haiqiang Yao, Chun-Su Yuan
Summary: Probiotics play a significant role in improving intestinal barrier function, immune function, inflammation, and microbiota composition, as evidenced by a systematic review and meta-analysis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Weijiang Zheng, Zuyan Zhao, Yunnan Yang, Liren Ding, Wen Yao
Summary: This study aimed to investigate the protective effects of synbiotic mixture containing lactulose and Bacillus coagulans on intestinal mucosal injury and barrier dysfunction under immune challenge in weaned piglets. The results showed that the synbiotic mixture could protect against intestinal damage and barrier dysfunction in piglets under immune challenge. These findings suggest that synbiotic mixture containing lactulose and Bacillus coagulans has beneficial effects on performance and resilience to immune stress in weaned piglets.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Meng-Meng Niu, Huan-Xin Guo, Jun-Wu Cai, Bo-Fan Duan, Yu-Han Chen, Xiang-Chen Meng
Summary: This study found that an exopolysaccharide (BBE) from Bifidobacterium breve could restore intestinal injury caused by colitis by increasing the survival ability of intestinal epithelial cells. BBE also inhibited oxidative protein expression, restored abnormal inflammatory factor production, and replenished short-chain fatty acids. Moreover, BBE regulated the imbalance of intestinal flora. Therefore, BBE has the potential to be used as an anti-inflammatory substance.
Article
Nutrition & Dietetics
Akio Kanazawa, Masanori Aida, Yasuto Yoshida, Hideyoshi Kaga, Takehiro Katahira, Luka Suzuki, Shoko Tamaki, Junko Sato, Hiromasa Goto, Kosuke Azuma, Tomoaki Shimizu, Takuya Takahashi, Yuichiro Yamashiro, Hirotaka Watada
Summary: The 24-week synbiotic supplementation did not significantly affect the changes in interleukin-6 in obese patients with type 2 diabetes, but resulted in positive changes in gut microbiota and fecal parameters.
Review
Biochemistry & Molecular Biology
Jun Chen, Haopeng Zhong, Zhouyin Huang, Xingping Chen, Jinming You, Tiande Zou
Summary: Kaempferol, a natural flavonoid, has shown significant potential in various biological activities. Recent studies have emphasized the role of kaempferol in regulating intestinal function and mitigating intestinal inflammation. This review focuses on its antioxidant properties, inflammation, maintenance of intestinal barrier function, and potential in the treatment of colorectal cancer and obesity.
Article
Biology
Deliang Liu, Shaobao Zhang, Siju Li, Qian Zhang, Ying Cai, Pei Li, Hao Li, Baochun Shen, Qiongfeng Liao, Yanjun Hong, Zhiyong Xie
Summary: This study found that P. distasonis could attenuate insulin resistance by repairing the intestinal barrier and reducing inflammation caused by the disturbed gut microbiota. Indoleacrylic acid was identified as the most significant factor correlated with the microbial alterations. P. distasonis enhanced insulin resistance by activating the aryl hydrocarbon receptor (AhR) signaling pathway and increasing the expression of intestinal barrier-related proteins. This research provides new therapeutic strategies for metabolic diseases by targeting the gut microbiota and tryptophan metabolism.