Article
Environmental Sciences
Alfredo Cordova-Martinez, Alberto Caballero-Garcia, Enrique Roche, David C. Noriega
Summary: Vaccination is the most effective strategy in the fight against COVID-19, with adjuvants playing a key role in enhancing vaccine efficacy and alleviating symptoms, especially in immunocompromised individuals like the elderly. Glucans, particularly beta-(1,3)-(1,6) glucans, are considered safe and effective adjuvants for boosting immune responses against the SARS-CoV-2 virus.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Ruediger Gross, Alexander Kleger
Summary: As emerging clinical analyses suggest an increased risk of new-onset diabetes following COVID-19, a causal link and underlying mechanisms are yet to be established. Persistence of hyperglycaemia after disease regression and the potential infection of non-pancreatic tissue are adding another layer of complexity to the relationship between COVID-19 and diabetes mellitus.
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Article
Multidisciplinary Sciences
Marcia C. Castro, Sun Kim, Lorena Barberia, Ana Freitas Ribeiro, Susie Gurzenda, Karina Braga Ribeiro, Erin Abbott, Jeffrey Blossom, Beatriz Rache, Burton H. Singer
Summary: The study found that COVID-19 in Brazil is spreading rapidly across municipalities with distinct spatial and temporal patterns of clustering, trajectories, and speed. Analysis shows that inadequate policy measures have led to high transmission and mortality burdens. The current surge in cases and deaths, along with the circulation of concerning variants, highlights the need for government to strengthen prevention and control measures.
Article
Medicine, General & Internal
Peter Chen, Ajay Nirula, Barry Heller, Robert L. Gottlieb, Joseph Boscia, Jason Morris, Gregory Huhn, Jose Cardona, Bharat Mocherla, Valentina Stosor, Imad Shawa, Andrew C. Adams, Jacob Van Naarden, Kenneth L. Custer, Lei Shen, Michael Durante, Gerard Oakley, Andrew E. Schade, Janelle Sabo, Dipak R. Patel, Paul Klekotka, Daniel M. Skovronsky
Summary: LY-CoV555, a neutralizing antibody, showed promising results in reducing viral load, improving symptoms, and lowering the risk of hospitalization among patients with mild or moderate Covid-19. While one of the doses appeared to accelerate the decline in viral load, others did not show significant effects by day 11.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Constantinos Kurt Wibmer, Frances Ayres, Tandile Hermanus, Mashudu Madzivhandila, Prudence Kgagudi, Brent Oosthuysen, Bronwen E. Lambson, Tulio de Oliveira, Marion Vermeulen, Karin van der Berg, Theresa Rossouw, Michael Boswell, Veronica Ueckermann, Susan Meiring, Anne von Gottberg, Cheryl Cohen, Lynn Morris, Jinal N. Bhiman, Penny L. Moore
Summary: The SARS-CoV-2 virus in the B.1.351 variant discovered in South Africa can evade neutralization by most antibodies when expressed, but does not affect binding by convalescent plasma. This suggests the potential for reinfection with antigenically distinct variants and predicts reduced efficacy of spike-based vaccines.
Article
Multidisciplinary Sciences
Emanuele Andreano, Ida Paciello, Silvia Marchese, Lorena Donnici, Giulio Pierleoni, Giulia Piccini, Noemi Manganaro, Elisa Pantano, Valentina Abbiento, Piero Pileri, Linda Benincasa, Ginevra Giglioli, Margherita Leonardi, Piet Maes, Concetta De Santi, Claudia Sala, Emanuele Montomoli, Raffaele De Francesco, Rino Rappuoli
Summary: In this study, Andreano and Paciello et al. provide insights into the functional and genetic characteristics of the Omicron BA.1 and BA.2 cross-protective antibody response. Their findings reveal that SARS-CoV-2 vaccines can induce neutralizing antibodies that cross-neutralize the Omicron variants and SARS-CoV-1 virus.
NATURE COMMUNICATIONS
(2022)
Review
Public, Environmental & Occupational Health
Sazada Siddiqui, Heba Waheeb Saeed Alhamdi, Huda Ahmed Alghamdi
Summary: COVID-19 is highly contagious and has caused major disruptions around the world. Prevention is crucial through measures such as self-isolation and vaccination.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
William R. Morgenlander, Stephanie N. Henson, Daniel R. Monaco, Athena Chen, Kirsten Littlefield, Evan M. Bloch, Eric Fujimura, Ingo Ruczinski, Andrew R. Crowley, Harini Natarajan, Savannah E. Butler, Joshua A. Weiner, Mamie Z. Li, Tania S. Bonny, Sarah E. Benner, Ashwin Balagopal, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Susan H. Eshleman, Arturo Casadevall, Andrew D. Redd, Oliver Laeyendecker, Margaret E. Ackerman, Andrew Pekosz, Stephen J. Elledge, Matthew Robinson, Aaron A. R. Tobian, H. Benjamin Larman
Summary: This study found strong correlation between the functionality of COVID-19 convalescent plasma and polyclonal antibody targeting of specific peptides in the SARS-CoV-2 spike protein. Antibody responses to specific coronaviruses correlated with the development of highly neutralizing antibodies against CoV-2. Plasma donations reactive to the CoV-2 spike receptor binding domain had higher neutralizing titers.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Infectious Diseases
Chang-Sheng Xia, Minghua Zhan, Yudong Liu, Zhi-Hong Yue, Ying Song, Feifei Zhang, Hui Wang
Summary: This study assessed the levels of protective antibodies in SARS survivors with and without the COVID-19 vaccine, and found that SARS survivors have protective antibodies against SARS-CoV-2 even without vaccination, and generate a stronger antibody response after vaccination compared to controls.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Review
Infectious Diseases
Dasha Majra, Jayme Benson, Jennifer Pitts, Justin Stebbing
Summary: Super spreader events (SSEs) can be categorized into 'societal' and 'isolated' events, with the former posing a greater threat and the latter being more easily quarantined.
JOURNAL OF INFECTION
(2021)
Article
Biochemistry & Molecular Biology
Zeli Zhang, Jose Mateus, Camila H. Coelho, Jennifer M. Dan, Carolyn Rydyznski Moderbacher, Rosa Isela Galvez, Fernanda H. Cortes, Alba Grifoni, Alison Tarke, James Chang, E. Alexandar Escarrega, Christina Kim, Benjamin Goodwin, Nathaniel Bloom, April Frazier, Daniela Weiskopf, Alessandro Sette, Shane Crotty
Summary: Multiple COVID-19 vaccines have successfully protected against symptomatic cases and deaths. Comparisons of T cell, B cell, and antibody responses to different vaccines can provide insights into protective immunity against COVID-19, particularly immune memory. mRNA vaccines and Ad26.COV2.S induced strong T cell responses, while mRNA vaccines showed substantial declines in antibodies.
Review
Multidisciplinary Sciences
Daniel M. Altmann, Rosemary J. Boyton
Summary: A diverse range of first-generation SARS-CoV-2 vaccines have been successful in controlling the COVID-19 pandemic, although inequitable distribution remains an issue. Future challenges include optimizing immunological boosting strategies and building an immune repertoire that can protect against upcoming viral variants.
Article
Public, Environmental & Occupational Health
Ewelina Janowska-Miasik, Anna Waskiewicz, Anna Maria Witkowska, Wojciech Drygas, Maria Wik Markhus, Malgorzata Elzbieta Zujko, Marian Kjellevold
Summary: There are significant differences in the national supplies for most food products in Poland and Norway, with subtle differences in the national dietary guidelines and nutritional recommendations. Both countries show inadequate intake of certain nutrients like folate, vitamin D, iron, calcium, magnesium, potassium, and thiamine. Despite better food diversity in Norway, there are still deficiencies in key micronutrients that require national action to address. Educational campaigns are needed to improve dietary literacy and compliance with dietary guidelines.
Meeting Abstract
Cardiac & Cardiovascular Systems
A. M. Witkowska, A. Waskiewicz, M. E. Zujko, D. Szczesniewska, W. Drygas
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2021)
Article
Nutrition & Dietetics
Kamila Szalwinska, Monika Cyunczyk, Jan Kochanowicz, Anna M. Witkowska
Summary: This study found that individuals with epilepsy tend to have higher LDL cholesterol, body fat, and lower lean body mass compared to healthy controls. Epileptic patients were less physically active and had inadequate intake of protein and vitamins, but consumed less coffee and alcohol. It is recommended to provide comprehensive medical care and advice on nutrition and physical activity for epilepsy patients.
Article
Nutrition & Dietetics
Anna Maria Witkowska, Anna Waskiewicz, Malgorzata Elzbieta Zujko, Iwona Mironczuk-Chodakowska, Alicja Cicha-Mikolajczyk, Wojciech Drygas
Summary: This study aimed to evaluate the size and sources of dietary plant sterols in the adult population of Poland. The research found that plant sterol intake in Poland is comparable to other populations, with women having denser diets in plant sterols. Future studies should expand and complete databases on plant sterol content in foods.
Article
Nutrition & Dietetics
Karolina Kujawowicz, Iwona Mironczuk-Chodakowska, Anna Maria Witkowska
Summary: This study examined the prevalence of orthorexia in individuals with celiac disease, and found that 71% of celiac disease patients had a risk of orthorexia. Age was positively correlated with the risk of orthorexia, and those at risk were more likely to prepare their own meals and pay less attention to the caloric content of food.
Article
Biochemistry & Molecular Biology
Monika Cyunczyk, Malgorzata Elzbieta Zujko, Jacek Jamiolkowski, Kinga Zujko, Magda Lapinska, Magdalena Zalewska, Marcin Kondraciuk, Anna Maria Witkowska, Karol Adam Kaminski
Summary: This study found a significant association between higher dietary total antioxidant capacity (DTAC) and lower prevalence of prediabetes in the Bialystok PLUS population. DTAC was also inversely associated with insulin resistance. DTAC was positively related to individual dietary antioxidants.
Review
Nutrition & Dietetics
Monika Sejbuk, Iwona Mironczuk-Chodakowska, Anna Maria Witkowska
Summary: Sleep quality can be influenced by multiple factors, such as nutrition, stimulant use, and physical activity. Sleep disorders and insomnia can contribute to various health issues.
Article
Nutrition & Dietetics
Malgorzata Elzbieta Zujko, Anna Waskiewicz, Anna Maria Witkowska, Alicja Cicha-Mikolajczyk, Kinga Zujko, Wojciech Drygas
Summary: This study aimed to assess the relationship between dietary total antioxidant capacity (DTAC) and the occurrence of cardiovascular diseases (CVDs), as well as healthy diet quality. The results showed that higher DTAC was associated with a higher intake of polyphenols, antioxidant vitamins, and minerals. Additionally, a higher DTAC was associated with a reduced odds ratio for cardiovascular diseases and a higher healthy diet quality.
Article
Nutrition & Dietetics
Anna Maria Witkowska, Anna Waskiewicz, Malgorzata Elzbieta Zujko, Alicja Cicha-Mikolajczyk, Iwona Mironczuk-Chodakowska, Wojciech Drygas
Summary: This study investigated the association between habitual intake of plant sterols and cardiovascular disease (CVD) in Polish adults. The results suggest that habitual dietary intake of plant sterols may be associated with a lower chance of developing CVD, particularly in men.
Review
Biochemistry & Molecular Biology
Anna Maria Witkowska, Joe-Elie Salem
Summary: The gut microbiota plays a crucial role in cardiometabolic disorders. By combining metabolomic and metagenomic approaches, the effects of drugs, diet, and specific foods on cardiometabolic health are described, and potential targets for future research are identified.
