期刊
NUTRIENTS
卷 13, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/nu13124285
关键词
diabetes; metabotypes; (poly)phenols; urolithins
资金
- Fundacao para a Ciencia e Tecnologia (FCT)/Ministerio da Ciencia e do Ensino Superior [PTDC/BIA-MOL/31104/2017, UIDB/04567/2020, UIDP/04567/2020]
- FCT/Ministerio da Ciencia e do Ensino Superior [LISBOA-01-0145-FEDER-007344]
- FEDER under the PT2020 Partnership Agreement
- FCT [PD/BD/135504/2018, UI/BD/151421/2021, CEEC/04567/CBIOS/2020]
- Fundação para a Ciência e a Tecnologia [UIDB/04567/2020, PD/BD/135504/2018, UI/BD/151421/2021, PTDC/BIA-MOL/31104/2017, UIDP/04567/2020] Funding Source: FCT
Diabetes remains a major cause of mortality and comorbidities, requiring improved management strategies, with dietary ellagitannins showing positive effects on diabetes by metabolizing into urolithins which can reach target tissues in significant concentrations.
Diabetes remains one of the leading causes of deaths and co-morbidities in the world, with tremendous human, social and economic costs. Therefore, despite therapeutics and technological advancements, improved strategies to tackle diabetes management are still needed. One of the suggested strategies is the consumption of (poly)phenols. Positive outcomes of dietary (poly)phenols have been pointed out towards different features in diabetes. This is the case of ellagitannins, which are present in numerous foodstuffs such as pomegranate, berries, and nuts. Ellagitannins have been reported to have a multitude of effects on metabolic diseases. However, these compounds have high molecular weight and do not reach circulation at effective concentrations, being metabolized in smaller compounds. After being metabolized into ellagic acid in the small intestine, the colonic microbiota hydrolyzes and metabolizes ellagic acid into dibenzopyran-6-one derivatives, known as urolithins. These low molecular weight compounds reach circulation in considerable concentrations ranging until micromolar levels, capable of reaching target tissues. Different urolithins are formed throughout the metabolization process, but urolithin A, isourolithin A, and urolithin B, and their phase-II metabolites are the most frequent ones. In recent years, urolithins have been the focus of attention in regard to their effects on a multiplicity of chronic diseases, including cancer and diabetes. In this review, we will discuss the latest advances about the protective effects of urolithins on diabetes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据