AD-16 Protects Against Hypoxic-Ischemic Brain Injury by Inhibiting Neuroinflammation

Propofol Protects Regulatory T Cells, Suppresses Neurotoxic Astrogliosis, and Potentiates Neurological Recovery After Ischemic Stroke

(2021) Yuzhu Wang et al.   Neuroscience Bulletin

Compound AD110 acts as therapeutic management for Alzheimer’s disease and stroke in mouse and rat models

(2020) Ping Sun et al.   ACS Chemical Neuroscience

Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice

(2019) Ai-Hua Liu et al.   Neuroscience Bulletin

Shared genes between Alzheimer’s disease and ischemic stroke

(2019) Chang-Juan Wei et al.   CNS Neuroscience & Therapeutics

MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy

(2019) Bo Li et al.   Cellular & Molecular Immunology

Microglia and Monocytes/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke

(2017) Masato Kanazawa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Brain-immune interactions in perinatal hypoxic-ischemic brain injury

(2017) Bo Li et al.   PROGRESS IN NEUROBIOLOGY

TREM2 protects against cerebral ischemia/reperfusion injury

(2017) Rong Wu et al.   Molecular Brain

Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer’s Disease Models

(2016) Wei Zhou et al.   ACS Chemical Neuroscience

Inhibition of Signal Transducer and Activator of Transcription 3 (STAT3) reduces neonatal hypoxic-ischaemic brain damage

(2016) Mariya Hristova et al.   JOURNAL OF NEUROCHEMISTRY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Temporal Characterization of Microglia/Macrophage Phenotypes in a Mouse Model of Neonatal Hypoxic-Ischemic Brain Injury

(2016) Nina Hellström Erkenstam et al.   Frontiers in Cellular Neuroscience

Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia

(2016) Thomas Wood et al.   Scientific Reports

Neuronal KATP channels mediate hypoxic preconditioning and reduce subsequent neonatal hypoxic–ischemic brain injury

(2015) Hong-Shuo Sun et al.   EXPERIMENTAL NEUROLOGY

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Deficiency Attenuates Phagocytic Activities of Microglia and Exacerbates Ischemic Damage in Experimental Stroke

(2015) M. Kawabori et al.   JOURNAL OF NEUROSCIENCE

Hypoxic Preconditioning Suppresses Glial Activation and Neuroinflammation in Neonatal Brain Insults

(2015) Chien-Yi Chen et al.   MEDIATORS OF INFLAMMATION

The role of inflammation in perinatal brain injury

(2015) Henrik Hagberg et al.   Nature Reviews Neurology

Antimicrobial Peptides and Complement in Neonatal Hypoxia-Ischemia Induced Brain Damage

(2015) Eridan Rocha-Ferreira et al.   Frontiers in Immunology

Therapeutic Hypothermia for Neonatal Hypoxic–Ischemic Encephalopathy – Where to from Here?

(2015) Joanne O. Davidson et al.   Frontiers in Neurology

TRPM7 Regulates Axonal Outgrowth and Maturation of Primary Hippocampal Neurons

(2014) Ekaterina Turlova et al.   MOLECULAR NEUROBIOLOGY

Inflammatory responses in hypoxic ischemic encephalopathy

(2013) Fudong Liu et al.   ACTA PHARMACOLOGICA SINICA

Time Is Brain: Starting Therapeutic Hypothermia within Three Hours after Birth Improves Motor Outcome in Asphyxiated Newborns

(2013) Marianne Thoresen et al.   Neonatology

Attenuated Inflammatory Response in Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Knock-Out Mice following Stroke

(2013) Matthias W. Sieber et al.   PLoS One

Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries

(2012) Sylvie Girard et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroprotective mechanisms of hypothermia in brain ischaemia

(2012) Midori A. Yenari et al.   NATURE REVIEWS NEUROSCIENCE

Involvement of the Akt/GSK-3β/CRMP-2 pathway in axonal injury after hypoxic–ischemic brain damage in neonatal rat

(2012) T. Xiong et al.   NEUROSCIENCE

Childhood Outcomes after Hypothermia for Neonatal Encephalopathy

(2012) Seetha Shankaran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immediate Hypothermia Is Not Neuroprotective After Severe Hypoxia-Ischemia and Is Deleterious When Delayed by 12 Hours in Neonatal Rats

(2012) Hemmen Sabir et al.   STROKE

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

Regulation of Toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia

(2011) Linnea Stridh et al.   Journal of Neuroinflammation

Perinatal Acidosis and Hypoxic-Ischemic Encephalopathy in Preterm Infants of 33 to 35 Weeks’ Gestation

(2011) Lina F. Chalak et al.   JOURNAL OF PEDIATRICS

Epidemiology of neonatal encephalopathy and hypoxic–ischaemic encephalopathy

(2010) Jennifer J. Kurinczuk et al.   EARLY HUMAN DEVELOPMENT

The Flavanol (−)-Epicatechin Prevents Stroke Damage through the Nrf2/HO1 Pathway

(2010) Zahoor A Shah et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nuclear translocation and calpain-dependent reduction of Bcl-2 after neonatal cerebral hypoxia–ischemia

(2009) Changlian Zhu et al.   BRAIN BEHAVIOR AND IMMUNITY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY