期刊
ACS CATALYSIS
卷 12, 期 1, 页码 724-732出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.1c04766
关键词
nickel catalysis; 1,3-diene; triflate; organometallic reagent; diarylation
资金
- Ministry of Education of Singapore [R-143-000-B57114]
The study demonstrates a new method for the highly efficient and site-selective 1,2-diarylation of aliphatic-1,3-dienes using N-heterocyclic carbene (NHC)-Ni(0) catalyst, allowing for the synthesis of products containing tertiary or quaternary centers.
Aliphatic-1,3-dienes represent a problematic class of substrates for catalytic 1,2-dicarbofunctionalization due to inherent complications of undesired allylic rearrangement, consequently giving rise to inseparable isomeric product mixtures. Here, we show that aliphatic-1,3-dienes can participate in highly efficient and site-selective 1,2-diarylation, by merging with an aryl triflate and arylmetal reagent in the presence of a sizeable N-heterocyclic carbene (NHC)- Ni(0) catalyst. Adducts containing tertiary or quaternary centers and those derived from multifunctional bioactive molecules could be obtained.
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