Development and characterization of functional antibodies targeting NMDA receptors

Enhanced binding of the N501Y‐mutated SARS‐CoV‐2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations

(2021) Binquan Luan et al.   FEBS LETTERS

Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors

(2021) Han Wang et al.   NEURON

Structural Basis of Functional Transitions in Mammalian NMDA Receptors

(2020) Tsung-Han Chou et al.   CELL

Generalized correlation-based dynamical network analysis: a new high-performance approach for identifying allosteric communications in molecular dynamics trajectories

(2020) Marcelo C. R. Melo et al.   JOURNAL OF CHEMICAL PHYSICS

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors

(2019) Michael C. Regan et al.   Nature Communications

Robust Determination of Protein Allosteric Signaling Pathways

(2019) Wesley M. Botello-Smith et al.   Journal of Chemical Theory and Computation

Dissecting diverse functions of NMDA receptors by structural biology

(2019) Jue Xiang Wang et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Real-time cryo-electron microscopy data preprocessing with Warp

(2019) Dimitry Tegunov et al.   NATURE METHODS

GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth

(2018) Leanne Li et al.   CANCER CELL

Structural Mechanism of Functional Modulation by Gene Splicing in NMDA Receptors

(2018) Michael C. Regan et al.   NEURON

cisTEM, user-friendly software for single-particle image processing

(2018) Timothy Grant et al.   eLife

Mechanism of NMDA receptor channel block by MK-801 and memantine

(2018) Xianqiang Song et al.   NATURE

Mechanisms for Zinc and Proton Inhibition of the GluN1/GluN2A NMDA Receptor

(2018) Farzad Jalali-Yazdi et al.   CELL

Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors

(2018) Jin-Bao Zhang et al.   Cell Reports

Novel Mode of Antagonist Binding in NMDA Receptors Revealed by the Crystal Structure of the GluN1-GluN2A Ligand-Binding Domain Complexed to NVP-AAM077

(2017) Annabel Romero-Hernandez et al.   MOLECULAR PHARMACOLOGY

Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits

(2017) Genevieve E. Lind et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation

(2017) Wei Lü et al.   SCIENCE

Mechanism of NMDA Receptor Inhibition and Activation

(2016) Shujia Zhu et al.   CELL

Activation of NMDA receptors and the mechanism of inhibition by ifenprodil

(2016) Nami Tajima et al.   NATURE

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function

(2016) David H. Hackos et al.   NEURON

Molecular Basis for Subtype Specificity and High-Affinity Zinc Inhibition in the GluN1-GluN2A NMDA Receptor Amino-Terminal Domain

(2016) Annabel Romero-Hernandez et al.   NEURON

Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta

(2016) Ray Yu-Ruei Wang et al.   eLife

MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories

(2015) Robert T. McGibbon et al.   BIOPHYSICAL JOURNAL

A structural biology perspective on NMDA receptor pharmacology and function

(2015) Michael C Regan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Emerging structural insights into the function of ionotropic glutamate receptors

(2015) Erkan Karakas et al.   TRENDS IN BIOCHEMICAL SCIENCES

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

Structural Insights into Competitive Antagonism in NMDA Receptors

(2014) Annie Jespersen et al.   NEURON

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

(2014) Matthew P. Parsons et al.   NEURON

Distinct Functional and Pharmacological Properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA Receptors

(2014) Kasper B. Hansen et al.   NEURON

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion

(2013) Leanne Li et al.   CELL

Anti-NMDA Receptor Encephalitis Antibody Binding Is Dependent on Amino Acid Identity of a Small Region within the GluN1 Amino Terminal Domain

(2012) A. J. Gleichman et al.   JOURNAL OF NEUROSCIENCE

A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice

(2012) Ronald B. DeMattos et al.   NEURON

MDAnalysis: A toolkit for the analysis of molecular dynamics simulations

(2011) Naveen Michaud-Agrawal et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Separation of Domain Contacts Is Required for Heterotetrameric Assembly of Functional NMDA Receptors

(2011) A. N. Farina et al.   JOURNAL OF NEUROSCIENCE

Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors

(2011) Erkan Karakas et al.   NATURE

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors

(2011) Katie M. Vance et al.   Nature Communications

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis

(2010) E. G. Hughes et al.   JOURNAL OF NEUROSCIENCE

Structure of the zinc-bound amino-terminal domain of the NMDA receptor NR2B subunit

(2009) Erkan Karakas et al.   EMBO JOURNAL

Two-state selection of conformation-specific antibodies

(2009) J. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors

(2008) Yongneng Yao et al.   EMBO JOURNAL

CHARMM-GUI: A web-based graphical user interface for CHARMM

(2008) Sunhwan Jo et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY