A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis

Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors

(2020) Chase H. Melick et al.   BIOCHEMICAL JOURNAL

Cell-Autonomous versus Systemic Akt Isoform Deletions Uncovered New Roles for Akt1 and Akt2 in Breast Cancer

(2020) Xinyu Chen et al.   MOLECULAR CELL

AKAP Signaling Islands: Venues for Precision Pharmacology

(2020) Mitchell H. Omar et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

Accurate and sensitive quantitation of glucose and glucose phosphates derived from storage carbohydrates by mass spectrometry

(2019) Lyndsay E.A. Young et al.   CARBOHYDRATE POLYMERS

A partnership with the proteasome; the destructive nature of GSK3

(2018) Holly Robertson et al.   BIOCHEMICAL PHARMACOLOGY

Mapping the Mouse Cell Atlas by Microwell-Seq

(2018) Xiaoping Han et al.   CELL

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation

(2018) Veronique Nogueira et al.   eLife

Single cell RNA-sequencing identifies a metabolic aspect of apoptosis in Rbf mutant

(2018) Majd M. Ariss et al.   Nature Communications

Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation

(2017) V L Sodi et al.   ONCOGENE

Snail1-dependent p53 repression regulates expansion and activity of tumour-initiating cells in breast cancer

(2016) Ting Ni et al.   NATURE CELL BIOLOGY

Discovery of a Novel 2,6-Disubstituted Glucosamine Series of Potent and Selective Hexokinase 2 Inhibitors

(2016) Hong Lin et al.   ACS Medicinal Chemistry Letters

Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3

(2015) John D. Hayes et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220

(2015) Jennifer L. Whiting et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer

(2014) H. D. Tran et al.   CANCER RESEARCH

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis

(2012) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

GlcNAcylation Plays an Essential Role in Breast Cancer Metastasis

(2010) Y. Gu et al.   CANCER RESEARCH

Snail1 is stabilized by O-GlcNAc modification in hyperglycaemic condition

(2010) Sang Yoon Park et al.   EMBO JOURNAL

Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes

(2010) Frank Christian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An enzymatic fluorimetric assay for glucose-6-phosphate: Application in an in vitro Warburg-like effect

(2009) Aiping Zhu et al.   ANALYTICAL BIOCHEMISTRY

FiehnLib: Mass Spectral and Retention Index Libraries for Metabolomics Based on Quadrupole and Time-of-Flight Gas Chromatography/Mass Spectrometry

(2009) Tobias Kind et al.   ANALYTICAL CHEMISTRY

Glycogen Synthase Kinase 3β Interaction Protein Functions as an A-kinase Anchoring Protein

(2009) Christian Hundsrucker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 Hyperactivity Inhibits Serum Deprivation-Induced Apoptosis via Increased Hexokinase II and GLUT1 Expression, Sustained Mcl-1 Expression, and Glycogen Synthase Kinase 3  Inhibition

(2009) P. T. Bhaskar et al.   MOLECULAR AND CELLULAR BIOLOGY

Analyses of Resected Human Brain Metastases of Breast Cancer Reveal the Association between Up-Regulation of Hexokinase 2 and Poor Prognosis

(2009) D. Palmieri et al.   MOLECULAR CANCER RESEARCH