A general theoretical framework to design base editors with reduced bystander effects
出版年份 2021 全文链接
标题
A general theoretical framework to design base editors with reduced bystander effects
作者
关键词
-
出版物
Nature Communications
Volume 12, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-11-11
DOI
10.1038/s41467-021-26789-5
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Computer simulations explain mutation-induced effects on the DNA editing by adenine base editors
- (2020) Kartik L. Rallapalli et al. Science Advances
- Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning
- (2020) Mandana Arbab et al. CELL
- Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
- (2020) Andrew V. Anzalone et al. NATURE BIOTECHNOLOGY
- CRISPResso2 provides accurate and rapid genome editing sequence analysis
- (2019) Kendell Clement et al. NATURE BIOTECHNOLOGY
- Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
- (2018) Luke W Koblan et al. NATURE BIOTECHNOLOGY
- Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA
- (2018) Atanu Maiti et al. Nature Communications
- An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
- (2018) Jason M Gehrke et al. NATURE BIOTECHNOLOGY
- Base editing: precision chemistry on the genome and transcriptome of living cells
- (2018) Holly A. Rees et al. NATURE REVIEWS GENETICS
- pmx Webserver: A User Friendly Interface for Alchemistry
- (2017) Vytautas Gapsys et al. Journal of Chemical Information and Modeling
- Alchemical Free Energy Calculations for Nucleotide Mutations in Protein–DNA Complexes
- (2017) Vytautas Gapsys et al. Journal of Chemical Theory and Computation
- Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
- (2017) Nicole M. Gaudelli et al. NATURE
- Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
- (2017) Y Bill Kim et al. NATURE BIOTECHNOLOGY
- Molecular origin of the weak susceptibility of kinesin velocity to loads and its relation to the collective behavior of kinesins
- (2017) Qian Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity
- (2017) Takahide Kouno et al. Nature Communications
- Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity
- (2017) Alexis C. Komor et al. Science Advances
- Accurate and Rigorous Prediction of the Changes in Protein Free Energies in a Large-Scale Mutation Scan
- (2016) Vytautas Gapsys et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- Teleseismic S wave microseisms
- (2016) K. Nishida et al. SCIENCE
- Development and Applications of CRISPR-Cas9 for Genome Engineering
- (2014) Patrick D. Hsu et al. CELL
- pmx: Automated protein structure and topology generation for alchemical perturbations
- (2014) Vytautas Gapsys et al. JOURNAL OF COMPUTATIONAL CHEMISTRY
- GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit
- (2013) Sander Pronk et al. BIOINFORMATICS
- NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity
- (2013) In-Ja L. Byeon et al. Nature Communications
- New Soft-Core Potential Function for Molecular Dynamics Based Alchemical Free Energy Calculations
- (2012) Vytautas Gapsys et al. Journal of Chemical Theory and Computation
- Refinement of the Cornell et al. Nucleic Acids Force Field Based on Reference Quantum Chemical Calculations of Glycosidic Torsion Profiles
- (2011) Marie Zgarbová et al. Journal of Chemical Theory and Computation
- Performance of Molecular Mechanics Force Fields for RNA Simulations: Stability of UUCG and GNRA Hairpins
- (2010) Pavel Banáš et al. Journal of Chemical Theory and Computation
- Improved side-chain torsion potentials for the Amber ff99SB protein force field
- (2010) Kresten Lindorff-Larsen et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started