期刊
JOURNAL OF FUNCTIONAL FOODS
卷 87, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2021.104783
关键词
Basil; Free radicals; Oxidative stress; Antioxidant enzymes; Acute liver injury
The study found that basil extract has a protective effect on acetaminophen-induced acute liver injury in rats, reducing oxidative stress and enhancing antioxidant enzyme activity. Serum levels of aspartate aminotransferase and alanine aminotransferase were significantly lower in animals treated with basil extract compared to controls.
This research aimed to examine the effects of pre-treatment with basil extract, prepared as an infusion, on acetaminophen-induced acute liver injury in rats. In vitro analysis of total phenolic, flavonoid content, and antioxidant activity was performed by spectrophotometric methods. Effects of basil extract on oxidative stress parameters, biochemical markers of liver injury, and liver morphology were determined in an in vivo model of acetaminophen-induced liver injury in Wistar rats. Total phenolic content was 52.61 +/- 1.35 mg GAE/g of DE, and flavonoid content was 0.5 +/- 0.2 mg QE/g of DE. IC50 values ranged from 0.22 to 45.76 mu g/ml for DPPH radical, OH radical, H2O2 and lipid peroxidation. Ascorbic acid was used as a positive control. The extract lowered the intensity of lipid peroxidation and potentiated the activity of antioxidant enzymes. In addition, serum levels of aspartate aminotransferase and alanine aminotransferase were significantly lower in basil extract-treated animals in comparison to respective controls.
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