From Synapses to Circuits, Astrocytes Regulate Behavior

Behaviorally consequential astrocytic regulation of neural circuits

(2021) Jun Nagai et al.   NEURON

Astrocytic cAMP modulates memory via synaptic plasticity

(2021) Zhiwen Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knockdown of the astrocytic glucocorticoid receptor in the central nucleus of the amygdala diminishes conditioned fear expression and anxiety

(2021) Lucja Wiktorowska et al.   BEHAVIOURAL BRAIN RESEARCH

Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents

(2021) Jérôme Wahis et al.   NATURE NEUROSCIENCE

Chemogenetic manipulation of astrocytic signaling in the basolateral amygdala reduces binge‐like alcohol consumption in male mice

(2021) Kala N. Nwachukwu et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ion Channels and Electrophysiological Properties of Astrocytes: Implications for Emergent Stimulation Technologies

(2021) Jessica McNeill et al.   Frontiers in Cellular Neuroscience

Transient Astrocytic Gq Signaling Underlies Remote Memory Enhancement

(2021) Youichi Iwai et al.   Frontiers in Neural Circuits

Cortical astrocytes independently regulate sleep depth and duration via separate GPCR pathways

(2021) Trisha V Vaidyanathan et al.   eLife

Astrocytic NMDA Receptors in the Basolateral Amygdala Contribute to Facilitation of Fear Extinction

(2021) Gajanan P Shelkar et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Specific and behaviorally consequential astrocyte Gq GPCR signaling attenuation in vivo with iβARK

(2021) Jun Nagai et al.   NEURON

Neurovascular Coupling in Development and Disease: Focus on Astrocytes

(2021) Teresa L. Stackhouse et al.   Frontiers in Cell and Developmental Biology

Astrocyte-Neuron Signaling in Synaptogenesis

(2021) Lili Shan et al.   Frontiers in Cell and Developmental Biology

Astrocyte-derived thrombospondin induces cortical synaptogenesis in a sex-specific manner

(2021) Anna Mazur et al.   eNeuro

Improved tools to study astrocytes

(2020) Xinzhu Yu et al.   NATURE REVIEWS NEUROSCIENCE

Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

(2020) Michelle Corkrum et al.   NEURON

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

Activation of Astrocytes in the Dorsomedial Striatum Facilitates Transition from Habitual to Goal-Directed Reward-Seeking Behavior

(2020) Seungwoo Kang et al.   BIOLOGICAL PSYCHIATRY

Transcriptomic profiling of microglia and astrocytes throughout aging

(2020) Jie Pan et al.   Journal of Neuroinflammation

Parallel astrocyte calcium signaling modulates olfactory bulb responses

(2020) Kevin Ung et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map

(2020) Omer Ali Bayraktar et al.   NATURE NEUROSCIENCE

Cortical astrocytes regulate ethanol consumption and intoxication in mice

(2020) E. K. Erickson et al.   NEUROPSYCHOPHARMACOLOGY

G-Protein-Coupled Receptors in Astrocyte–Neuron Communication

(2020) Paulo Kofuji et al.   NEUROSCIENCE

Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning

(2020) Adi Kol et al.   NATURE NEUROSCIENCE

Astrocyte modulation of extinction impairments in ethanol-dependent female mice

(2020) Laura L. Giacometti et al.   NEUROPHARMACOLOGY

Astrocytic Ca2+ signaling is reduced during sleep and is involved in the regulation of slow wave sleep

(2020) Laura Bojarskaite et al.   Nature Communications

Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

(2020) Kevin A. Guttenplan et al.   Nature Communications

Astrocytes modulate sensory-evoked neuronal network activity

(2020) Justin Lines et al.   Nature Communications

SpiCee: A Genetic Tool for Subcellular and Cell-Specific Calcium Manipulation

(2020) Oriol Ros et al.   Cell Reports

Revealing the structure of pharmacobehavioral space through motion sequencing

(2020) Alexander B. Wiltschko et al.   NATURE NEUROSCIENCE

Myelin plasticity: sculpting circuits in learning and memory

(2020) Wendy Xin et al.   NATURE REVIEWS NEUROSCIENCE

Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus

(2020) Hankyul Kwak et al.   NEURON

Neuropeptides Modulate Local Astrocytes to Regulate Adult Hippocampal Neural Stem Cells

(2020) Brent Asrican et al.   NEURON

Astroglial Calcium Signaling Encodes Sleep Need in Drosophila

(2020) Ian D. Blum et al.   CURRENT BIOLOGY

GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors

(2020) Sara Mederos et al.   NATURE NEUROSCIENCE

Glia as sculptors of synaptic plasticity

(2020) Laura Sancho et al.   NEUROSCIENCE RESEARCH

Star power: the emerging role of astrocytes as neuronal partners during cortical plasticity

(2020) Jérôme Wahis et al.   CURRENT OPINION IN NEUROBIOLOGY

Striatal Astrocytes Shape Behavioral Flexibility via Regulation of the Glutamate Transporter EAAT2

(2020) Arjen J. Boender et al.   BIOLOGICAL PSYCHIATRY

Melanopsin for precise optogenetic activation of astrocyte-neuron networks

(2019) Sara Mederos et al.   GLIA

Astrocyte function from information processing to cognition and cognitive impairment

(2019) Mirko Santello et al.   NATURE NEUROSCIENCE

Cell-autonomous clock of astrocytes drives circadian behavior in mammals

(2019) Marco Brancaccio et al.   SCIENCE

Gi/o protein-coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission

(2019) Caitlin A. Durkee et al.   GLIA

Hyperactivity with Disrupted Attention by Activation of an Astrocyte Synaptogenic Cue

(2019) Jun Nagai et al.   CELL

Transient, Consequential Increases in Extracellular Potassium Ions Accompany Channelrhodopsin2 Excitation

(2019) J. Christopher Octeau et al.   Cell Reports

Glia Accumulate Evidence that Actions Are Futile and Suppress Unsuccessful Behavior

(2019) Yu Mu et al.   CELL

Myelinated axon physiology and regulation of neural circuit function

(2019) Daumante Suminaite et al.   GLIA

Impairments in remote memory caused by the lack of Type 2 IP 3 receptors

(2019) António Pinto‐Duarte et al.   GLIA

Review Article: Tools and trends for probing brain neurochemistry

(2019) Abraham G. Beyene et al.   JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A

Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference

(2019) Min-Ho Nam et al.   Cell Reports

Cortex-wide Changes in Extracellular Potassium Ions Parallel Brain State Transitions in Awake Behaving Mice

(2019) Rune Rasmussen et al.   Cell Reports

Mechanisms of systems memory consolidation during sleep

(2019) Jens G. Klinzing et al.   NATURE NEUROSCIENCE

Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology

(2019) Yizhi Wang et al.   NATURE NEUROSCIENCE

Fluorescent Biosensors for Neurotransmission and Neuromodulation: Engineering and Applications

(2019) Anna V. Leopold et al.   Frontiers in Cellular Neuroscience

Regulation of food intake by astrocytes in the brainstem dorsal vagal complex

(2019) Alastair J. MacDonald et al.   GLIA

Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement

(2018) Adar Adamsky et al.   CELL

Astrocytes, neurons, synapses: a tripartite view on cortical circuit development

(2018) Isabella Farhy-Tselnicker et al.   Neural Development

Chemogenetic Manipulation of Dorsal Hippocampal Astrocytes Protects Against the Development of Stress-enhanced Fear Learning

(2018) Meghan E. Jones et al.   NEUROSCIENCE

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior

(2018) Sónia Guerra-Gomes et al.   Frontiers in Cellular Neuroscience

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

DeepLabCut: markerless pose estimation of user-defined body parts with deep learning

(2018) Alexander Mathis et al.   NATURE NEUROSCIENCE

Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior

(2018) Xinzhu Yu et al.   NEURON

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

(2018) Cristina García-Cáceres et al.   NATURE NEUROSCIENCE

Astrocytes Integrate Behavioral State and Vascular Signals during Functional Hyperemia

(2018) Cam Ha T. Tran et al.   NEURON

Diversity and Specificity of Astrocyte–neuron Communication

(2018) Caitlin A. Durkee et al.   NEUROSCIENCE

Astrocyte glycogen and lactate: New insights into learning and memory mechanisms

(2017) Cristina M. Alberini et al.   GLIA

Astroglial glutamate transporters in the brain: Regulating neurotransmitter homeostasis and synaptic transmission

(2017) Ciaran Murphy-Royal et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Synapse-specific astrocyte gating of amygdala-related behavior

(2017) Mario Martin-Fernandez et al.   NATURE NEUROSCIENCE

Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation

(2017) Isabella Farhy-Tselnicker et al.   NEURON

Toward a Wiring Diagram Understanding of Appetite Control

(2017) Mark L. Andermann et al.   NEURON

Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling

(2017) Marco Brancaccio et al.   NEURON

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

(2017) Amit Agarwal et al.   NEURON

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle

(2017) Jerome Clasadonte et al.   NEURON

Astrocytic IP3/Ca2+ Signaling Modulates Theta Rhythm and REM Sleep

(2017) Jeannine Foley et al.   Frontiers in Neural Circuits

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

(2016) Cristina García-Cáceres et al.   CELL

Activation of hypothalamic astrocytes suppresses feeding without altering emotional states

(2016) Patrick Sweeney et al.   GLIA

Ca2+transients in astrocyte fine processes occur via Ca2+influx in the adult mouse hippocampus

(2016) Ravi L. Rungta et al.   GLIA

Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state

(2016) Stephanie L Padilla et al.   NATURE NEUROSCIENCE

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

New Transgenic Mouse Lines for Selectively Targeting Astrocytes and Studying Calcium Signals in Astrocyte Processes In Situ and In Vivo

(2016) Rahul Srinivasan et al.   NEURON

DREADDs for Neuroscientists

(2016) Bryan L. Roth   NEURON

Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone

(2016) J.A. Filosa et al.   NEUROSCIENCE

Astrocytes: Orchestrating synaptic plasticity?

(2016) M. De Pittà et al.   NEUROSCIENCE

Astrocytes regulate cortical state switching in vivo

(2016) Kira E. Poskanzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes as new targets to improve cognitive functions

(2016) Glenn Dallérac et al.   PROGRESS IN NEUROBIOLOGY

Direct modulation of GFAP-expressing glia in the arcuate nucleus bi-directionally regulates feeding

(2016) Naiyan Chen et al.   eLife

Gliotransmitter Release from Astrocytes: Functional, Developmental, and Pathological Implications in the Brain

(2016) Kazuki Harada et al.   Frontiers in Neuroscience

Optogenetic and Chemogenetic Approaches for Studying Astrocytes and Gliotransmitters

(2016) Juwon Bang et al.   Experimental Neurobiology

A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice

(2016) Andrea Wolf et al.   PLoS One

Gq-DREADD Selectively Initiates Glial Glutamate Release and Inhibits Cue-induced Cocaine Seeking

(2015) Michael D. Scofield et al.   BIOLOGICAL PSYCHIATRY

Astrocyte Dysfunction Induced by Alcohol in Females but Not Males

(2015) Clare J. Wilhelm et al.   BRAIN PATHOLOGY

Hypothalamic Agrp Neurons Drive Stereotypic Behaviors beyond Feeding

(2015) Marcelo O. Dietrich et al.   CELL

Optogenetic stimulation of astrocytes in the posterior hypothalamus increases sleep at night in C57BL/6J mice

(2015) Dheeraj Pelluru et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The inhibitory neurotransmitter GABA evokes long-lasting Ca2+oscillations in cortical astrocytes

(2015) Letizia Mariotti et al.   GLIA

Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory

(2015) Anna G Orr et al.   NATURE NEUROSCIENCE

Astrocyte Calcium Signaling: From Observations to Functions and the Challenges Therein

(2015) Baljit S. Khakh et al.   Cold Spring Harbor Perspectives in Biology

Astrocytes Control Food Intake by Inhibiting AGRP Neuron Activity via Adenosine A1 Receptors

(2015) Liang Yang et al.   Cell Reports

Evidence for a novel functional role of astrocytes in the acute homeostatic response to high-fat diet intake in mice

(2015) Laura B. Buckman et al.   Molecular Metabolism

Comparative analysis of optogenetic actuators in cultured astrocytes

(2014) Melina Figueiredo et al.   CELL CALCIUM

Assessing Spatial Learning and Memory in Rodents

(2014) C. V. Vorhees et al.   ILAR JOURNAL

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Neuronal Transgene Expression in Dominant-Negative SNARE Mice

(2014) T. Fujita et al.   JOURNAL OF NEUROSCIENCE

Targeting cells with single vectors using multiple-feature Boolean logic

(2014) Lief E Fenno et al.   NATURE METHODS

Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding

(2014) Jae Geun Kim et al.   NATURE NEUROSCIENCE

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

(2014) Martin Paukert et al.   NEURON

Rat Nucleus Accumbens Core Astrocytes Modulate Reward and the Motivation to Self-Administer Ethanol after Abstinence

(2014) Cecilia Bull et al.   NEUROPSYCHOPHARMACOLOGY

Female mice liberated for inclusion in neuroscience and biomedical research

(2014) Brian J. Prendergast et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Astrocytes contribute to gamma oscillations and recognition memory

(2014) H. S. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytic activation in the anterior cingulate cortex is critical for sleep disorder under neuropathic pain

(2014) Akira Yamashita et al.   SYNAPSE

Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo

(2014) Gertrudis Perea et al.   Nature Communications

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses

(2013) Eiji Shigetomi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Modulation of the autonomic nervous system and behaviour by acute glial cell Gqprotein-coupled receptor activationin vivo

(2013) Cendra Agulhon et al.   JOURNAL OF PHYSIOLOGY-LONDON

Molecular and cellular cognition: Neurobiology of Learning and Memory Special Issue 2013

(2013) Ted Abel et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Sleep Drives Metabolite Clearance from the Adult Brain

(2013) L. Xie et al.   SCIENCE

Hypothalamic tanycytes: potential roles in the control of feeding and energy balance

(2013) Matei Bolborea et al.   TRENDS IN NEUROSCIENCES

Astroglial Excitability and Gliotransmission: An Appraisal of Ca2+ as a Signalling Route

(2012) Robert Zorec et al.   ASN Neuro

Astrocyte Calcium Signal and Gliotransmission in Human Brain Tissue

(2012) M. Navarrete et al.   CEREBRAL CORTEX

Leptin regulates glutamate and glucose transporters in hypothalamic astrocytes

(2012) Esther Fuente-Martín et al.   JOURNAL OF CLINICAL INVESTIGATION

Astrocyte–Neuron Communication: Functional Consequences

(2012) Sarrah Ben Achour et al.   NEUROCHEMICAL RESEARCH

Application of an optogenetic byway for perturbing neuronal activity via glial photostimulation

(2012) T. Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regional Astrocyte Allocation Regulates CNS Synaptogenesis and Repair

(2012) H.-H. Tsai et al.   SCIENCE

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

Genetically encoded neural activity indicators

(2011) Loren L Looger et al.   CURRENT OPINION IN NEUROBIOLOGY

GABAergic signaling by AgRP neurons prevents anorexia via a melanocortin-independent mechanism

(2011) Qi Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

(2011) Michael J. Krashes et al.   JOURNAL OF CLINICAL INVESTIGATION

Astrocyte-Derived Adenosine and A1 Receptor Activity Contribute to Sleep Loss-Induced Deficits in Hippocampal Synaptic Plasticity and Memory in Mice

(2011) C. Florian et al.   JOURNAL OF NEUROSCIENCE

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

Local Ca2+ detection and modulation of synaptic release by astrocytes

(2011) Maria Amalia Di Castro et al.   NATURE NEUROSCIENCE

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

A genetically targeted optical sensor to monitor calcium signals in astrocyte processes

(2010) Eiji Shigetomi et al.   NATURE NEUROSCIENCE

Synaptic plasticity and Ca2+ signalling in astrocytes

(2010) Christian Henneberger et al.   Neuron Glia Biology

Specific disruption of astrocytic Ca2+ signaling pathway in vivo by adeno-associated viral transduction

(2010) Y. Xie et al.   NEUROSCIENCE

Sex bias in neuroscience and biomedical research

(2010) Annaliese K. Beery et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity

(2010) T. L. Horvath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

Cellular mechanisms of estradiol-mediated sexual differentiation of the brain

(2010) Christopher L. Wright et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Astrocytes going live: advances and challenges

(2009) Axel Nimmerjahn   JOURNAL OF PHYSIOLOGY-LONDON

Neuroscience: Glia — more than just brain glue

(2009) Nicola J. Allen et al.   NATURE

Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss

(2009) Michael M. Halassa et al.   NEURON

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

Motor Behavior Activates Bergmann Glial Networks

(2009) Axel Nimmerjahn et al.   NEURON

Leptin receptor mRNA in rat brain astrocytes

(2009) Hung Hsuchou et al.   PEPTIDES

Pavlovian fear conditioning as a behavioral assay for hippocampus and amygdala function: cautions and caveats

(2008) Stephen Maren   EUROPEAN JOURNAL OF NEUROSCIENCE

GFAPpromoter elements required for region-specific and astrocyte-specific expression

(2008) Youngjin Lee et al.   GLIA

Two Forms of Astrocyte Calcium Excitability Have Distinct Effects on NMDA Receptor-Mediated Slow Inward Currents in Pyramidal Neurons

(2008) E. Shigetomi et al.   JOURNAL OF NEUROSCIENCE

Loss of IP3 Receptor-Dependent Ca2+ Increases in Hippocampal Astrocytes Does Not Affect Baseline CA1 Pyramidal Neuron Synaptic Activity

(2008) J. Petravicz et al.   JOURNAL OF NEUROSCIENCE

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

What Is the Role of Astrocyte Calcium in Neurophysiology?

(2008) Cendra Agulhon et al.   NEURON

Tuned Responses of Astrocytes and Their Influence on Hemodynamic Signals in the Visual Cortex

(2008) J. Schummers et al.   SCIENCE