Salicylate metal-binding isosteres as fragments for metalloenzyme inhibition

A Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor

(2019) Christian Perez et al.   JOURNAL OF MEDICINAL CHEMISTRY

SAR Exploration of Tight Binding Inhibitors of Influenza Virus PA Endonuclease

(2019) Cy V. Credille et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metal-Binding Isosteres as New Scaffolds for Metalloenzyme Inhibitors

(2018) Benjamin L. Dick et al.   INORGANIC CHEMISTRY

Targeting Metalloenzymes for Therapeutic Intervention

(2018) Allie Y. Chen et al.   CHEMICAL REVIEWS

Riding the metalloproteinase roller coaster

(2017) Gillian Murphy   JOURNAL OF BIOLOGICAL CHEMISTRY

Dipicolinic Acid Derivatives as Inhibitors of New Delhi Metallo-β-lactamase-1

(2017) Allie Y. Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure Property Relationships of Carboxylic Acid Isosteres

(2016) Pierrik Lassalas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment-Based Identification of Influenza Endonuclease Inhibitors

(2016) Cy V. Credille et al.   JOURNAL OF MEDICINAL CHEMISTRY

Twenty years on: the impact of fragments on drug discovery

(2016) Daniel A. Erlanson et al.   NATURE REVIEWS DRUG DISCOVERY

Characterisation of selected active agents regarding pKa values, solubility concentrations and pH profiles by SiriusT3

(2015) D. Schönherr et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Design and evaluation of azaindole-substituted N-hydroxypyridones as glyoxalase I inhibitors

(2012) Takashi Chiba et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase

(2012) Eva Kowalinski et al.   PLoS Pathogens

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Identifying Chelators for Metalloprotein Inhibitors Using a Fragment-Based Approach

(2010) Jennifer A. Jacobsen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–activity relationship of human GLO I inhibitory natural flavonoids and their growth inhibitory effects

(2008) Ryoko Takasawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent Developments in Fragment-Based Drug Discovery

(2008) Miles Congreve et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structures of Human 108V and 108M Catechol O-Methyltransferase

(2008) K. Rutherford et al.   JOURNAL OF MOLECULAR BIOLOGY

The identification of an osteoclastogenesis inhibitor through the inhibition of glyoxalase I

(2008) M. Kawatani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA