Article
Pharmacology & Pharmacy
Chenxue Mei, Xiao Wang, Fanxiang Meng, Xiaoqing Zhang, Ling Chen, Siqi Yan, Junxiu Xue, Xun Sun, Yuanyuan Wang
Summary: Aucuboside, extracted from traditional Chinese medicine, possesses therapeutic effects on inflammatory bowel disease by suppressing the generation of Th17 cells and IL-17 expression, as well as partially reversing the decrease in Treg cell proportion. This previously unrecognized immunoregulatory function of aucuboside may have potential clinical applications in treating IBD.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Zhaocheng Li, Minling Lin, Yadi Li, Jing Shao, Ruiting Huang, Yongyi Qiu, Yi Liu, Lei Chen
Summary: Sophora flavescens Aiton total flavonoids extracts (SFE), especially the flavonoid ingredient Kurarinone, have significant immunoregulatory effects against ulcerative colitis (UC) by inhibiting the activation of the JAK2/STAT3 signaling pathway and regulating the differentiation of Th17/Treg cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Xue-Yuan Leng, Jia Yang, Heng Fan, Qian-Yun Chen, Bing-Jie Cheng, Hong-Xia He, Fei Gao, Feng Zhu, Ting Yu, Yu-Jin Liu
Summary: Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unclear etiology and pathogenesis. This study provides evidence that histone modification plays an important regulatory role in UC, identifying it as a potential therapeutic target.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Anella Saviano, Federica Raucci, Gian Marco Casillo, Adel Abo Mansour, Vincenzo Piccolo, Camilla Montesano, Martina Smimmo, Valentina Vellecco, Gennaro Capasso, Amedeo Boscaino, Vincenzo Summa, Nicola Mascolo, Asif Jilani Iqbal, Raffaella Sorrentino, Roberta d'Emmanuele di Villa Bianca, Mariarosaria Bucci, Vincenzo Brancaleone, Francesco Maione
Summary: In this study, the potential beneficial effects of Mangifera indica L. extract (MIE) in a mouse model of gouty arthritis were analyzed. The results demonstrated that MIE can positively affect the local and systemic inflammatory/immunological perturbance in the onset and progression of gouty arthritis by modulating cellular immune phenotypes, inhibiting joint inflammatory scores, reducing leukocyte infiltration and activation, and regulating the expression of pro-inflammatory cyto-chemokines.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Immunology
Yongzhi Hua, Ruiqi Liu, Min Lu, Xueneng Guan, Suyang Zhuang, Yaozhou Tian, Zhenhai Zhang, Li Cui
Summary: Juglone has been found to have therapeutic effects on ulcerative colitis in mice, modulating gut microbiota and restoring Th17/Treg balance. The results show that juglone can alleviate UC symptoms, reduce inflammatory protein levels, and impact gut microbiota and Th17/Treg ratio.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Meihua Liu, Zhonghua Wang, Xuan Liu, Hang Xiao, Yangcheng Liu, Jiaqi Wang, Changlan Chen, Xin Wang, Wei Liu, Zheng Xiang, Dongmei Yue
Summary: This study investigated the therapeutic effect and metabolic analysis of a traditional Chinese medicine prescription, Yiyi Fuzi Baijiang formula (YFB), on ulcerative colitis (UC) in rats induced by 2,4,6-trinitro-benzene sulfonic acid (TNBS). The results showed that YFB formula has an anti-inflammatory effect on UC by regulating the balance of Th17/Treg cells in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Juan Huang, Ziyan Yang, Yanyun Li, Xingxing Chai, Yanfang Liang, Bihua Lin, Ziyu Ye, Shaobing Zhang, Zhengping Che, Hailiang Zhang, Xueying Zhang, Zhao Zhang, Tao Chen, Weiqing Yang, Jincheng Zeng
Summary: This study demonstrates that the L.p R3 strain significantly improves symptoms and pathological damage in mice with colitis, and influences immune function by regulating the Th17/Treg cell balance in DSS-induced colitis in mice.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Anna Starshinova, Igor Kudryavtsev, Artem Rubinstein, Anna Malkova, Irina Dovgaluk, Dmitry Kudlay
Summary: COVID-19 infection affects the detection and immune response of tuberculosis (Tbc), and it is important to understand the immune response alterations in latent tuberculosis infection and in tuberculosis patients with SARS-CoV-2 infection. The findings suggest that COVID-19 may lead to disturbed immune responses and increase the risk of developing severe tuberculosis.
Article
Plant Sciences
Youbao Zhong, Wenjun Liu, Yanxia Xiong, Yingmeng Li, Qi Wan, Wen Zhou, Haimei Zhao, Qiuping Xiao, Duanyong Liu
Summary: AS-IV effectively prevents and alleviates ulcerative colitis by reshaping Th17/Treg cell homeostasis and anti-oxidative stress.
Article
Agriculture, Multidisciplinary
Cheng Cheng, Wei Zhang, Cong Zhang, Peng Ji, Xiaohui Wu, Zhou Sha, Xiang Chen, Yongkang Wang, Yugen Chen, Haibo Cheng, Liyun Shi
Summary: The study demonstrates that HYP treatment effectively alleviates ulcerative colitis in mice by reducing pathological scores, suppressing colonic inflammation, and balancing Th17/Treg response. Mechanistically, HYP enhances PPAR γ signaling by inhibiting MKRN1, promoting Treg differentiation and suppressing Th17 cell development.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Yaohua Fan, Yanqun Fan, Kunfeng Liu, Piyanuch Lonan, Feng Liao, Yuhang Huo, Xiaohua Zhong, Yueliang Liang, Yaxin Wang, Shaozhen Hou, Xiaoping Lai, Geng Li, Weihong Kuang
Summary: Edible bird's nest (EBN) as a Chinese medicine and food with high nutritional value, has been shown to have protective effects on DSS-induced colitis in mice, mainly by restoring the balance of Th17/Treg cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Mengjiao Yang, Qianwen Zhang, Reham Taha, Mohammed Ismail Abdelmotalab, Qing Wen, Yuzhu Yuan, Yongrui Zhao, Qingyu Li, Chunyu Liao, Xin Huang, Zhenzhou Jiang, Chenghan Chu, Chunhua Jiao, Lixin Sun
Summary: In this study, the therapeutic effect and mechanism of polysaccharide from Atractylodes macrocephala Koidz. (PAMK) in ulcerative colitis (UC) were systematically investigated. The results showed that PAMK treatment effectively alleviated DSS-induced colitis in mice by regulating the balance between Th17 and Treg cells and inhibiting the IL-6/STAT3 signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Yan Xiao, Jinxin Zhang, Xiangyu Zhu, Wenxin Zhao, Yiquan Li, Ningyi Jin, Huijun Lu, Jicheng Han
Summary: The Fu-Zheng-Xuan-Fei formula (FF) is a traditional Chinese medicine prescription used to treat viral pneumonia. However, there have been few pharmacological studies on its activity against influenza B virus (IBV).
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Cheng Cheng, Jingyi Hu, Yanan Li, Yuejin Ji, Ziyu Lian, Ryan Au, Feng Xu, Weiyang Li, Hong Shen, Lei Zhu
Summary: This study evaluated the therapeutic effects of Chinese herbal medicine Qing-Chang-Hua-Shi granule (QCHS) on colitis and revealed its mechanisms of action. The results showed that QCHS significantly alleviated colitis by suppressing the inflammatory response and balancing the Th17/Treg response. It was found that QCHS acted through the NLRP6 signaling pathway to modulate inflammation and drive Th17 cell differentiation.
Article
Medicine, Research & Experimental
Le Lv, Ziyang Chen, Wenhui Bai, Jiahui Hao, Zhengang Heng, Caijin Meng, Lin Wang, Xianglan Luo, Xinmiao Wang, Yanjun Cao, Jiao He
Summary: This study aimed to explore the efficacy of THDCA on ulcerative colitis and to reveal its mechanisms of action. The results showed that THDCA can significantly alleviate colitis and exert its effects by regulating the Th1/Th2 and Th17/Treg balance.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)