Review
Pharmacology & Pharmacy
Irina-Georgeta Sufaru, Silvia Teslaru, Liliana Pasarin, Gianina Iovan, Simona Stoleriu, Sorina Mihaela Solomon
Summary: This paper reviews the relationship between diabetes mellitus and periodontitis, as well as the main substances modulating the inflammatory response and their application in diabetic patients.
Review
Dentistry, Oral Surgery & Medicine
M. G. Balta, E. Papathanasiou, I. J. Blix, T. E. Van Dyke
Summary: Periodontitis is the sixth-most prevalent disease in the world and the leading cause of tooth loss in adults. Recent studies have shown that synthetic and biological disease-modifying antirheumatic drugs, such as rituximab and tocilizumab, can improve periodontal clinical parameters. Probiotics and nutritional supplements have also been found to provide anti-inflammatory benefits in the treatment of periodontitis.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Microbiology
Michael D. Huband, Jennifer D. Thompson, Nabina D. Gurung, Qingmei Liu, Li Li, Jay Zhang, Jennifer M. Streit, Mariana Castanheira
Summary: KBP-7072 is a novel broad-spectrum tetracycline that demonstrates potent activity against various bacterial pathogens, including resistant strains. The in vitro results suggest that KBP-7072 has potential for further clinical investigation in the treatment of different types of infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Review
Microbiology
Massimo Amato, Federica Di Spirito, Francesco D'Ambrosio, Giovanni Boccia, Giuseppina Moccia, Francesco De Caro
Summary: Periodontitis and peri-implantitis are diseases that lead to tooth and dental implant loss, and probiotics have been investigated for their potential beneficial effects. However, there is no definitive conclusion on the effectiveness of probiotics in periodontal management. Further studies are needed to validate their use and provide recommended protocols.
Review
Immunology
Tetsuhiro Kajikawa, Dimitrios C. Mastellos, Hatice Hasturk, Georgios A. Kotsakis, Despina Yancopoulou, John D. Lambris, George Hajishengallis
Summary: Periodontitis, if not properly treated, can lead to tooth loss and affect overall health. This review focuses on the potential use of a complement-targeting drug called AMY-101 in the treatment of periodontal disease and peri-implant inflammatory conditions.
SEMINARS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Ramasamy Kavitha, Mohammad Auwal Sa'ad, Shivkanya Fuloria, Neeraj Kumar Fuloria, Manickam Ravichandran, Pattabhiraman Lalitha
Summary: Periodontal disease is an oral disease that damages tooth-supporting tissue. This study aimed to develop novel molecules to combat the pathogens that cause periodontal disease. The synthesized compounds showed significant antimicrobial activity and minimal cytotoxicity, suggesting their potential application in periodontal disease treatment.
Article
Immunology
Matthias L. Braun, Markus B. Tomek, Clemens Gruenwald-Gruber, Phuong Q. Nguyen, Susanne Bloch, Jan S. Potempa, Oleh Andrukhov, Christina Schaeffer
Summary: This study confirms that Tannerella forsythia and Porphyromonas gingivalis affect the inflammatory response of the host immune system through different targets in the T9SS. The T9SS mutant of T. forsythia significantly reduces the production of cytokines and chemokines in human cells, while the opposite is observed for the T9SS mutant of P. gingivalis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jhefferson Miranda Alves, Danielle Borges Germano, Yeon Jung Kim, Francisco Antonio Helfenstein Fonseca, Maria Cristina Izar, Izabela Dorota Tuleta, Rogerio Nagai, Neil Ferreira Novo, Yara Juliano, Lucas Melo Neves, Debora Pallos, Carolina Nunes Franca
Summary: Non-surgical periodontal treatment can modulate the phenotype of monocytes to a less inflammatory state, particularly in individuals with diabetes.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Multidisciplinary Sciences
Qiuhe Lu, Thaddeus S. Stappenbeck
Summary: The dynamic community of microbes (microbiota) plays a vital role in maintaining host health through communication and interaction. Although there have been advances in understanding the associations between microbiota and host processes and diseases, translating this knowledge into effective treatments has been challenging. More research is needed to uncover the key contributors to host health, the impact of strain differences, and the functions of the chemical products produced by the microbiota.
Article
Biochemistry & Molecular Biology
Adelina S. Plachokova, Sergio Andreu-Sanchez, Marlies P. Noz, Jingyuan Fu, Niels P. Riksen
Summary: This study explores the relationship between the oral microbiome of periodontitis patients and disease severity and systemic inflammation. Significant differences in microbial composition were found between severe and mild periodontitis, particularly in subgingival microbiome, which was positively associated with systemic inflammatory markers like interleukin-6 and white blood cell count. The findings suggest that systemic inflammation in severe periodontitis may be driven by the oral microbiome, supporting the indirect inflammatory mechanism linking periodontitis to cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ramona Gabriela Ursu, Luminita Smaranda Iancu, Elena Porumb-Andrese, Costin Damian, Roxana Gabriela Cobzaru, Giorgio Nichitean, Carmen Ripa, Darius Sandu, Ionut Luchian
Summary: Recent applications of mRNA analysis in periodontal disease have provided insights into the pathogenic mechanisms and therapeutic target genes, offering potential pathways for preventing periodontal disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Otari Chipashvili, Daniel R. Utter, Joseph K. Bedree, Yansong Ma, Fabian Schulte, Gabrielle Mascarin, Yasmin Alayyoubi, Deepak Chouhan, Markus Hardt, Felicitas Bidlack, Hatice Hasturk, Xuesong He, Jeffrey S. McLean, Batbileg Bor
Summary: The study found that Saccharibacteria (TM7) can reduce inflammation and bone loss by modulating host bacterial pathogenicity, potentially protecting mammalian hosts from inflammatory damage caused by their host bacteria.
CELL HOST & MICROBE
(2021)
Article
Multidisciplinary Sciences
Xiaomin Liu, Xin Tong, Zhuye Jie, Jie Zhu, Liu Tian, Qiang Sun, Yanmei Ju, Leying Zou, Haorong Lu, Xuemei Qiu, Qiang Li, Yunli Liao, Heng Lian, Yong Zuo, Xiaomin Chen, Weiqiao Rao, Yan Ren, Yuan Wang, Jin Zi, Rong Wang, Xun Xu, Huanming Yang, Jian Wang, Yang Zong, Weibin Liu, Yong Hou, Xin Jin, Liang Xiao, Karsten Kristiansen, Huijue Jia, Tao Zhang
Summary: In this study, the composition of the oral microbiome and its major host factors were investigated in 4,478 individuals and significant differences between sexes were found. Through sex-stratified analysis, 11 differential genetic associations with the oral microbiome were identified, and causalities between the oral microbiome and serum metabolites were discovered. These findings highlight the importance of sex stratification and deepen our understanding of the interplay between the oral microbiome and serum metabolites.
Article
Dentistry, Oral Surgery & Medicine
Xulei Yuan, Fuyuan Zhou, He Wang, Xinxin Xu, Shihan Xu, Chuangwei Zhang, Yanan Zhang, Miao Lu, Yang Zhang, Mengjiao Zhou, Han Li, Ximu Zhang, Tingwei Zhang, Jinlin Song
Summary: Long-term use of antibiotics can lead to gut dysbiosis, which can disrupt the oral microbiota and aggravate periodontitis. Fecal microbiota transplantation from normal mice can restore the balance of gut microbiota, decrease the pathogenicity of the oral microbiota, reverse the Th17/Treg imbalance in periodontal tissue, and alleviate alveolar bone loss. This study highlights the potential adverse effects of long-term systemic antibiotics-induced gut dysbiosis on the oral microbiota and periodontitis, emphasizing the need for regular assessment of periodontal condition in patients using systemic antibiotics in clinical practice.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2023)
Review
Cell Biology
Hang Zou, Niu Zhou, Yilian Huang, Aoxiang Luo, Jianbo Sun
Summary: Periodontitis is a common chronic inflammatory disease, where regulatory lymphocytes such as Bregs and Tregs play important roles. Restoring immune balance through therapeutic targeting of regulatory lymphocytes is a promising strategy for the treatment of periodontitis and other systemic inflammatory diseases.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
M. S. Elburki, D. D. Moore, N. G. Terezakis, Y. Zhang, H. -M. Lee, F. Johnson, L. M. Golub
JOURNAL OF PERIODONTAL RESEARCH
(2017)
Article
Endocrinology & Metabolism
Yazhou Zhang, Steve A. McClain, Hsi-Ming Lee, Muna S. Elburki, Huiwen Yu, Ying Gu, Yu Zhang, Mark Wolff, Francis Johnson, Lorne M. Golub
JOURNAL OF DIABETES RESEARCH
(2016)
Article
Cell Biology
Muna S. Elburki, Carlos Rossa, Morgana R. Guimares-Stabili, Hsi-Ming Lee, Fabiana A. Curylofo-Zotti, Francis Johnson, Lorne M. Golub
Article
Dentistry, Oral Surgery & Medicine
Fabiana Almeida Curylofo-Zotti, Muna S. Elburki, Priscilla Aparecida Oliveira, Paulo Sergio Cerri, Leandro Alves Santos, Hsi-Ming Lee, Francis Johnson, Lorne M. Golub, Carlos Rossa Junior, Morgana Rodrigues Guimaraes-Stabili
ARCHIVES OF ORAL BIOLOGY
(2018)
Article
Cell Biology
Muna S. Elburki, Carlos Rossa, Morgana R. Guimaraes, Mark Goodenough, Hsi-Ming Lee, Fabiana A. Curylofo, Yu Zhang, Francis Johnson, Lorne M. Golub
MEDIATORS OF INFLAMMATION
(2014)