Review
Biochemistry & Molecular Biology
Yukihito Higashi
Summary: Oxidative stress and chronic inflammation play a crucial role in the development of atherosclerosis, as vascular endothelial dysfunction leads to its progression and forms a vicious cycle with oxidative stress and inflammation.
Review
Biochemistry & Molecular Biology
Yousef A. Al-Dashti, Roberta R. Holt, Carl L. Keen, Robert M. Hackman
Summary: Research on cardioprotective foods like dates is essential for addressing global public health needs. While animal studies show promising results, more human research is needed to fully understand the potential benefits of date fruit on vascular health. Conducting thorough clinical trials and assessing functional markers of vascular disease will provide valuable information for human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Kabelo Mokgalaboni, Sanele Dlamini, Wendy N. Phoswa, Perpetua Modjadji, Sogolo L. Lebelo
Summary: Diabetes mellitus is a major contributor to cardiovascular disease and mortality rates worldwide. Despite the use of pharmaceutical drugs, diabetes prevalence is alarmingly rising, necessitating the search for remedies with lower toxicity. Pomegranate, known for its properties and safety, has been investigated in research and trials. However, conflicting reports exist on its effects in diabetes. Therefore, this systematic review analyzed evidence from preclinical and clinical trials, focusing on oxidative stress, inflammation, and endothelial function in diabetes. The analyzed evidence suggests that pomegranate has the potential to alleviate these markers, but further clinical trials are needed for validation.
Article
Nutrition & Dietetics
Masoud Khorshidi, Aliakbar Sayyari, Naheed Aryaeian, Beheshteh Olang, Mohammadreza Alaei, Mitra Khalili, Amirhossein Hosseini, Masoud Salehi
Summary: This study found that omega-3 supplementation can improve vascular function and reduce triglyceride levels in adolescents with T1DM, potentially reducing the risk of cardiovascular disease.
FRONTIERS IN NUTRITION
(2022)
Review
Food Science & Technology
Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Harprit Singh, Mariasole Da Boit
Summary: Anthocyanins, a type of flavonoid polyphenols, have been studied for their potential in improving cardiovascular health and preventing endothelial dysfunction. However, their poor bioavailability raises questions about the role of their metabolites in the observed biological activity. Recent studies have used different models and concentrations to better understand the mechanisms of action of these compounds. The review highlights the need for further research on improving the bioavailability of the metabolites and exploring the effects of metabolites in mixtures.
Article
Biochemistry & Molecular Biology
Adriana Leandro, Marcelo Queiroz, Lara Azul, Raquel Seica, Cristina M. Sena
Summary: The study demonstrates that omentin-1 has a positive impact on endothelial function and PVAT in non-obese type 2 diabetes mellitus animals, improving vascular relaxation, reducing oxidative stress, enhancing PVAT anti-contractile action, and alleviating pro-inflammatory status.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Environmental Sciences
Sarah Easson, Radha Dutt Singh, Liam Connors, Taylor Scheidl, Larissa Baker, Anshul Jadli, Hai-Lei Zhu, Jennifer Thompson
Summary: This study found that the commonly used BPA substitute BPS can disturb redox balance and increase the production of reactive oxygen species (ROS), leading to impaired endothelial function.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Naris Thengchaisri, Lih Kuo, Travis W. Hein
Summary: In diabetes, the increased activity of the enzyme arginase competes with endothelial nitric oxide synthase (eNOS) for their common substrate L-arginine, leading to compromised vasodilation mediated by nitric oxide (NO). However, eNOS uncoupling in diabetes may result in the production of superoxide and compensatory hydrogen peroxide (H2O2) formation to restore NO deficiency. This study found that in early type 1 diabetes, the vasodilation response in coronary arterioles was partially impaired due to reduced availability of L-arginine as a result of upregulated arginase activity. Nevertheless, the increased production of H2O2 during eNOS uncoupling and PI3K activation seemed to compensate for the NO deficiency and mask the disturbance caused by arginase activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ghulam Yahya Amiry, Murtaza Haidary, Hassan Azhdari-Zarmehri, Farimah Beheshti, S. Mohammad Ahmadi-Soleimani
Summary: In this study, we investigated the effects of adolescent nicotine exposure and subsequent abstinence on anxiety and depressive behaviors in rats. Nicotine withdrawal exacerbated anxiety behaviors through changes in oxidative stress balance, inflammatory response, and serotonin metabolism. Omega-3 fatty acid pre-treatment significantly prevented nicotine withdrawal-induced complications by restoring the mentioned biochemical changes. Overall, we suggest omega-3 fatty acid supplementation as a safe, inexpensive, and effective strategy for preventing or ameliorating detrimental effects caused by nicotine withdrawal at the cellular and behavioral levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Claudia Rodriguez, Ana Sanchez, Javier Saenz-Medina, Mercedes Munoz, Medardo Hernandez, Miguel Lopez, Luis Rivera, Cristina Contreras, Dolores Prieto
Summary: Obesity-induced dysregulation of AMPK activity is the underlying cause of kidney vascular dysfunction, and activation of AMPK improves metabolic state, protects renal endothelial function, and exerts potent vascular antioxidant and anti-inflammatory effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Immunology
Manpreet Singh, Obed Barrera Adame, Michael Nickas, Jeremiah Robison, Christopher Khatchadourian, Vishwanath Venketaraman
Summary: This paper explores the underlying mechanisms and pathophysiology in individuals with diabetes and insulin resistance, making them more prone to worse outcomes after SARS-CoV-2 infection. It proposes adjunctive therapies, such as glutathione, Vitamin D, and steroids, to combat the cytokine surge seen in COVID-19. Research has found that diabetes patients have an underlying inflammatory state and are more susceptible to SARS-CoV-2 infection. Glutathione, Vitamin D, and steroids may have positive effects on the condition of diabetes patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marcelo Queiroz, Adriana Leandro, Lara Azul, Artur Figueirinha, Raquel Seica, Cristina M. Sena
Summary: Luteolin was found to improve endothelial function, vascular oxidative stress, and perivascular adipose tissue in type 2 diabetes mellitus rats, showing therapeutic potential for vascular complications associated with type 2 diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Matthew C. Babcock, Lyndsey E. DuBose, Teresa L. Witten, Brian L. Stauffer, Kerry L. Hildreth, Robert S. Schwartz, Wendy M. Kohrt, Kerrie L. Moreau
Summary: Low testosterone in middle-aged/older men is associated with age-associated endothelial dysfunction, potentially due to increased oxidative stress and inflammation.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Anna Tylutka, Barbara Morawin, Edyta Wawrzyniak-Gramacka, Eryk Wacka, Wiktoria Nowicka, Jaroslaw Hiczkiewicz, Agnieszka Zembron-Lacny
Summary: This study reveals the association between immunosenescence-related disproportion in T lymphocytes and endothelial dysfunction, highlighting its potential impact on vascular aging. Assessing the inflammatory-immune profile could help better predict and prevent vascular diseases associated with old age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Abigayle B. Simon, Cassandra C. Derella, Marsha Blackburn, Jeffrey Thomas, Lawrence C. Layman, Matthew S. Nicholson, Jennifer Waller, Ahmed Elmarakby, Karim M. Saad, Ryan A. Harris
Summary: The study found that women with type 1 diabetes have higher levels of estradiol in the late follicular phase, leading to increased oxidative stress and endothelial dysfunction. The use of oral contraceptive pills appears to benefit endothelial function in patients with type 1 diabetes.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Chemistry, Medicinal
Naheed Aryaeian, Mahsa Hadidi, Mahdi Mahmoudi, Marziyeh Asgari, Zohreh Sajadi Hezaveh, Sara Khorshidi Sadehi
Summary: Black barberry extract may alleviate the severity of rheumatoid arthritis, decrease IL-17 levels, and increase IL-10 levels, showing a potential for modulating inflammation and enhancing anti-inflammatory effects in RA.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Negin Tahvilian, Mohsen Masoodi, Amirhossein Faghihi Kashani, Mohammadreza Vafa, Naheed Aryaeian, Azadeh Heydarian, AghaFateme Hosseini, Nariman Moradi, Farnaz Farsi
Summary: Supplementation with saffron was found to improve antioxidant status and reduce disease severity in patients with ulcerative colitis, indicating its potential as an alternative therapy for UC patients.
PHYTOTHERAPY RESEARCH
(2021)
Article
Chemistry, Medicinal
Shayan Akbari, Mohammad Hassan Sohouli, Saeedeh Ebrahimzadeh, Fariborz Mansour Ghanaei, Agha Fatemeh Hosseini, Naheed Aryaeian
Summary: This study aimed to examine the impact of rosemary leaf powder on nonalcoholic fatty liver disease patients on a weight loss diet. The results showed that the use of rosemary leaf powder did not significantly improve liver function and biochemical parameters compared to the diet/activity intervention alone.
PHYTOTHERAPY RESEARCH
(2022)
Article
Nutrition & Dietetics
Masoud Khorshidi, Aliakbar Sayyari, Naheed Aryaeian, Beheshteh Olang, Mohammadreza Alaei, Mitra Khalili, Amirhossein Hosseini, Masoud Salehi
Summary: This study found that omega-3 supplementation can improve vascular function and reduce triglyceride levels in adolescents with T1DM, potentially reducing the risk of cardiovascular disease.
FRONTIERS IN NUTRITION
(2022)
Article
Obstetrics & Gynecology
Shahnaz Rimaz, Seyedeh Tayebeh Rahideh, Jamileh Abolghasemi, Shima Jazayeri, Sanaz Jamshidi, Manijeh Motevalian, Masoud Solaymani-Dodaran, Mohsen Taghizadeh, Afsaneh Gholamrezayi, Naheed Aryaeian
Summary: This study aims to evaluate the effect of Cornus mas fruit on menopausal symptoms and sex hormones in postmenopausal women. The findings indicate that the extract of C mas fruit can significantly reduce menopausal symptoms, decrease the frequency and duration of hot flushes, and improve sex hormone levels.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)
Article
Chemistry, Medicinal
Fateme Afandak, Naheed Aryaeian, Maryam Kashanian, Leila Janani, Tandis Namizadeh, Mohammad Yahya Karimi, Mehrnaz Morvaridi
Summary: The purpose of this study was to determine the effect of sumac powder on clinical symptoms and laboratory parameters in women with PCOS. The results showed that sumac powder can reduce inflammation, improve glycemic status and lipid profile in patients, but has no significant effect on anthropometric parameters and sex hormones.
PHYTOTHERAPY RESEARCH
(2023)
Article
Integrative & Complementary Medicine
Azadeh Heydarian, Amir Hossein Faghihi Kashani, Mohsen Masoodi, Naheed Aryaeian, Mohammadreza Vafa, Negin Tahvilian, Agha Fatemeh Hosseini, Soudabeh Fallah, Nariman Moradi, Farnaz Farsi
Summary: This study demonstrates that taking saffron tablets for eight weeks can reduce the levels of inflammatory cytokines in patients with ulcerative colitis.
JOURNAL OF HERBAL MEDICINE
(2022)
Review
Food Science & Technology
Mohadeseh Soleimani Damaneh, Somaye Fatahi, Naheed Aryaeian, Hossein Bavi Behbahani
Summary: Coenzyme Q10 supplementation significantly reduces serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT), indicating a positive effect on liver function. However, there is no significant impact on alkaline phosphatase concentration. Further high-quality randomized clinical trials with longer intervention periods and larger sample sizes are needed to validate these findings.
FOOD SCIENCE & NUTRITION
(2023)
Article
Integrative & Complementary Medicine
Mostafa Safari, Akbar Asadi, Naheed Aryaeian, Hasan Fallah Huseini, Farzad Shidfar, Shima Jazayeri, Mojtaba Malek, Agha Fateme Hosseini, Zahra Hamidi
Summary: This study aimed to determine the efficacy of M. officinalis extract on depression, anxiety, and sleep quality in patients with type 2 diabetes with depressive symptoms. The results showed a significant decrease in depression and anxiety severity in the intervention group compared to the baseline, but no significant differences were observed in FBS, hs-CRP, anthropometric indices, sleep quality, and blood pressure.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Geriatrics & Gerontology
Fahimeh Agh, Seyed Hadi Mousavi, Naheed Aryaeian, Fatemehsadat Amiri, Mohammad Reza Jalilvand, Motahareh Hasani, Farhad Vahid, Fatemeh Sepahvand, Mehran Vosugh
Summary: Bone marrow mesenchymal stem cells (BM-MSCs) play a significant role in the composition of the bone marrow microenvironment, with abilities such as immunomodulation and hematopoiesis. This study found that a high-calorie diet (HCD) accelerates BM-MSCs senescence, while vitamin D can reduce senescence biomarkers in BM-MSCs.
Review
Food Science & Technology
Azadeh Heydarian, Negin Tahvilian, Hossein Shahinfar, Seyed Ali Abbas-Hashemi, Reza Daryabeygi-Khotbehsara, Naheed Aryaeian
Summary: This study conducted a systematic review and meta-analysis to evaluate the anti-inflammatory and antihypertensive effects of cardamom in adults. The results showed that cardamom significantly reduced inflammatory factors and blood pressure. However, caution must be exercised due to the limited number of studies.
FOOD SCIENCE & NUTRITION
(2023)
Article
Food Science & Technology
Atie Sadat Khorasanian, Shima Jazayeri, Negar Omidi, Zahra Booyani, Mehrnaz Morvaridi, Mehdi Tehrani-Doost, Agha Fateme Hoseini, Mostafa Nejatian, Naheed Aryaeian
Summary: The aim of this study was to determine the effects of hesperidin on depression, serum BDNF, and serum cortisol levels in post-CABG patients. The results showed that a dose of 200 mg/day hesperidin can reduce depressive symptoms in post-CABG patients with mild depression.
FOOD SCIENCE & NUTRITION
(2023)
Article
Food Science & Technology
Zahra Booyani, Naheed Aryaeian, Negar Omidi, Atie Sadat Khorasanian, Agha Fatemeh Hoseini, Mostafa Nejatian, Shima Jazayeri, Mehrnaz Morvaridi
Summary: This study aimed to determine the effects of hesperidin supplementation on inflammation, oxidative stress, and lipid profile in depressed coronary artery bypass graft surgery (CABG) patients. The results showed that supplementation with hesperidin for 12 weeks significantly reduced triglyceride levels in patients, but had no significant effect on other parameters.
FOOD SCIENCE & NUTRITION
(2023)
Article
Nutrition & Dietetics
Sahar Jafari Karegar, Naheed Aryaeian, Ghazaleh Hajiluian, Katsuhiko Suzuki, Farzad Shidfar, Masoud Salehi, Bahram Haghi Ashtiani, Pooya Farhangnia, Ali-Akbar Delbandi
Summary: Ellagic acid supplementation has beneficial effects on disease severity and gene expression in multiple sclerosis (MS) patients. It reduces inflammatory cytokines, decreases inflammation, and increases anti-inflammatory cytokines, thus improving the health status of patients.
FRONTIERS IN NUTRITION
(2023)
Review
Medicine, General & Internal
Fahimeh Agh, Motahareh Hasani, Maryam Khazdouz, Fatemehsadat Amiri, Javad Heshmati, Naheed Aryaeian
Summary: This systematic review and meta-analysis found that zinc supplementation significantly increases the circulating levels of BDNF and zinc. These findings suggest a positive effect of zinc on the modulation of BDNF and zinc levels.
INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
(2022)
