DNA N6-methyldeoxyadenosine in mammals and human disease

Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions

(2021) Dan Yu et al.   NUCLEIC ACIDS RESEARCH

Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA

(2020) Min Zhang et al.   CELL RESEARCH

Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1

(2020) Li-Fei Tian et al.   CELL RESEARCH

DNA N6-methyladenine modification in hypertension

(2020) Ye Guo et al.   Aging-US

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

(2020) Huilin Huang et al.   CANCER CELL

N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA

(2020) Ziyang Hao et al.   MOLECULAR CELL

The origin of genomic N6-methyl-deoxyadenosine in mammalian cells

(2020) Michael U. Musheev et al.   Nature Chemical Biology

No evidence for DNA N6-methyladenine in mammals

(2020) Karolos Douvlataniotis et al.   Science Advances

N6-methyladenine in DNA antagonizes SATB1 in early development

(2020) Zheng Li et al.   NATURE

The epigenetic roles of DNA N6-Methyladenine (6mA) modification in eukaryotes

(2020) Kou-Juey Wu   CANCER LETTERS

The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction

(2019) Xiang Li et al.   NATURE NEUROSCIENCE

An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing

(2019) Soo-Mi Kweon et al.   MOLECULAR CELL

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

(2019) Eric Metzger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Adenine Methylation in Drosophila Is Associated with the Tissue-Specific Expression of Developmental and Regulatory Genes

(2019) Kinnary Shah et al.   G3-Genes Genomes Genetics

Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA

(2019) Zach K. O’Brown et al.   BMC GENOMICS

Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112

(2019) Clayton B. Woodcock et al.   Cell Discovery

Structural insight into human N6amt1–Trm112 complex functioning as a protein methyltransferase

(2019) Wenjing Li et al.   Cell Discovery

The Biogenesis and Precise Control of RNA m6A Methylation

(2019) Huilin Huang et al.   TRENDS IN GENETICS

Human MettL3–MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro

(2019) Clayton B. Woodcock et al.   Cell Discovery

N 6 -Methyladenine DNA Modification in the Human Genome

(2018) Chuan-Le Xiao et al.   MOLECULAR CELL

A reassessment of DNA-immunoprecipitation-based genomic profiling

(2018) Antonio Lentini et al.   NATURE METHODS

Active N6-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons

(2018) Bing Yao et al.   MOLECULAR CELL

N-methyladenine DNA Modification in Glioblastoma

(2018) Qi Xie et al.   CELL

Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome

(2018) Casslynn W Q Koh et al.   NUCLEIC ACIDS RESEARCH

Adenine N6-methylation in diverse fungi

(2017) Michael F Seidl   NATURE GENETICS

Widespread adenine N6-methylation of active genes in fungi

(2017) Stephen J Mondo et al.   NATURE GENETICS

DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?

(2017) Guan-Zheng Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA N6-methyladenine is dynamically regulated in the mouse brain following environmental stress

(2017) Bing Yao et al.   Nature Communications

DNA N6-methyladenine in metazoans: functional epigenetic mark or bystander?

(2017) Guan-Zheng Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ALKBH1-Mediated tRNA Demethylation Regulates Translation

(2016) Fange Liu et al.   CELL

DNA methylation on N6-adenine in mammalian embryonic stem cells

(2016) Tao P. Wu et al.   NATURE

Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig

(2016) Jianzhao Liu et al.   Nature Communications

Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification

(2015) Lakshminarayan M. Iyer et al.   BIOESSAYS

An Adenine Code for DNA: A Second Life for N6-Methyladenine

(2015) Holger Heyn et al.   CELL

DNA Methylation on N6-Adenine in C. elegans

(2015) Eric Lieberman Greer et al.   CELL

N6-Methyladenine DNA Modification in Drosophila

(2015) Guoqiang Zhang et al.   CELL

N6-Methyldeoxyadenosine Marks Active Transcription Start Sites in Chlamydomonas

(2015) Ye Fu et al.   CELL

TET1 is a tumor suppressor of hematopoietic malignancy

(2015) Luisa Cimmino et al.   NATURE IMMUNOLOGY

DNA N6-methyladenine: a new epigenetic mark in eukaryotes?

(2015) Guan-Zheng Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications

(2015) Magdalena J Koziol et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications

(2015) Magdalena J Koziol et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Determination of DNA adenine methylation in genomes of mammals and plants by liquid chromatography/mass spectrometry

(2015) Wei Huang et al.   RSC Advances

Diverse Functions of Restriction-Modification Systems in Addition to Cellular Defense

(2013) K. Vasu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics

(2013) Ming-Ming Li et al.   Nature Communications

Deficiency in a Glutamine-Specific Methyltransferase for Release Factor Causes Mouse Embryonic Lethality

(2010) P. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY