Article
Cell Biology
Olga Y. Rybina, Alexander V. Symonenko, Elena G. Pasyukova
Summary: Aging is a global concern, calling for urgent, effective, and large-scale interventions to reduce late-life chronic diseases and improve human healthspan. Anti-aging drug therapy is a promising strategy to combat aging effects. However, most geroprotective compounds only target a few aging-related factors, thus the use of combination interventions has a strong biological rationale.
AGEING RESEARCH REVIEWS
(2023)
Review
Endocrinology & Metabolism
Beatrice Oehler, Alexander Brack, Robert Blum, Heike L. Rittner
Summary: Oxidized phospholipids (OxPL) are highly reactive metabolites in the lipidome, produced acutely in inflamed tissue to induce pain. They excite neurons by activating specific ion channels and increase firing rate of nociceptors under inflammatory conditions. Targeting OxPL with specific drugs or antibodies can control acute inflammatory pain.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Plant Sciences
Liyuan Ke, Chenhui Zhong, Zhijie Chen, Ziyao Zheng, Shaoguang Li, Bing Chen, Qiaoyi Wu, Hong Yao
Summary: This study summarized the research progress on the anti-disease efficacy and effect mechanism of Tanshinone I (Tan I) in recent years and provided perspectives for future study on the active ingredient. The results showed that Tan I has multiple therapeutic effects, including protection of the cardiovascular system, anti-cancer, anti-inflammatory, anti-neurodegenerative diseases, etc. Key action targets for Tan I were identified as AKT1, CASP3, and STAT3, and potential therapeutic effects mechanisms were predicted through bioinformatics analyses.
Review
Biochemistry & Molecular Biology
Zhoupeng Li, Dehui Kong, Yongsheng Liu, Mingkai Li
Summary: Virus infections are a major cause of morbidity and mortality worldwide, with a lack of available therapeutic agents for most viruses. Recent research has highlighted the potential role of coumarin derivatives as antiviral agents, making them important for the inhibition of various viruses.
Review
Pharmacology & Pharmacy
Mahmoud S. Alghamri, Brandon L. McClellan, Margaret S. Hartlage, Santiago Haase, Syed Mohd Faisal, Rohit Thalla, Ali Dabaja, Kaushik Banerjee, Stephen V. Carney, Anzar A. Mujeeb, Michael R. Olin, James J. Moon, Anna Schwendeman, Pedro R. Lowenstein, Maria G. Castro
Summary: Gliomas, particularly glioblastomas, are highly aggressive and lethal cancers with unique molecular characteristics and genetic signatures. The interactions between tumor cells and immune cells in the tumor microenvironment play a critical role in glioma progression. Understanding the impact of inflammation and potential pharmacological interventions targeting neuro-inflammation are important for improving outcomes in glioma patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Elena G. Pasyukova, Alexander Symonenko, Olga Y. Rybina, Alexander M. Vaiserman
Summary: Developing interventions to improve healthspan is a priority for academic and public health authorities. Geroscience focuses on targeting aging as an effective way to combat age-related disorders. Epigenome-targeted interventions in geroscience research show promise in preventing and treating various aging-related conditions.
AGEING RESEARCH REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Min-Jee Jo, Joo-Kyung Lee, Ji-Eun Kim, Gang-Jee Ko
Summary: The rapid growth of the elderly population has led to an increased need for extensive and advanced information on age-related organ dysfunction. The kidney, being one of the organs most affected by aging, experiences functional decline, including reduced size, decreased filtration rate, changes in blood flow, and increased inflammation and fibrosis. This review provides a foundation for understanding the functional and molecular mechanisms of aging kidneys and identifies potential targets for future treatments of age-related kidney issues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Zhongxiao Lin, Qian Ding, Xinzhi Li, Yuliang Feng, Hao He, Chuoji Huang, YiZhun Zhu
Summary: Environment, diseases, lack of exercise, and aged tendency of population have become crucial factors that induce vascular aging, which is an unmodifiable risk factor for diseases like diabetes and hypertension. Recent transformative omics approaches have enabled a better understanding of vascular aging mechanisms, making it possible to slow down or reverse the aging process.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Medicine, Research & Experimental
Bulmaro Cisneros, Ian Garcia-Aguirre, Marlon De Ita, Isabel Arrieta-Cruz, Haydee Rosas-Vargas
Summary: Aging is the gradual decline of physical and psychological functions in humans, accompanied by the onset of chronic-degenerative diseases. The study of Hutchinson-Gilford progeria syndrome (HGPS) has provided insights into understanding the aging process. HGPS is caused by a genetic mutation that leads to the synthesis of progerin, a mutant version of lamin A. However, the mechanisms by which progerin induces detrimental alterations at the cellular and systemic levels are not fully understood.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Review
Multidisciplinary Sciences
Sergio Ramirez-Perez, Itzel Viridiana Reyes-Perez, Diana Emilia Martinez-Fernandez, Luis Alexis Hernandez-Palma, Pallavi Bhattaram
Summary: Arthritic diseases, particularly osteoarthritis, have a high global prevalence and significant socioeconomic impact. Chronic inflammation is a key driver of joint degeneration and pain in osteoarthritis, but effective therapeutic agents targeting inflammation are lacking. Inflammasomes have been identified as critical players in inflammatory diseases, including osteoarthritis. Understanding the activation of inflammasomes is crucial for developing effective therapies for osteoarthritis. This review discusses the contribution of extracellular mediators and intracellular activators to inflammasome activation in osteoarthritis, as well as the potential strategies for inflammasome blockade in therapy.
Review
Geriatrics & Gerontology
Die Hu, Fangfang Xie, Yongwei Xiao, Chen Lu, Jianing Zhong, Defa Huang, Jie Chen, Jifu Wei, Yu Jiang, Tianyu Zhong
Summary: Aging is a universal phenomenon characterized by a loss of reproductive capacity and declining fitness in all biological organisms. In humans, aging is associated with an increased incidence of diseases, making the aging population a primary public burden of the 21st century. The discovery of novel anti-aging drugs is crucial to delay the aging process and maintain the fitness of the aging population, with metformin gaining attention in recent years for its potential anti-aging effects.
Review
Biochemistry & Molecular Biology
Zhaoshi Bai, Yiran Zhou, Yaling Peng, Xinyue Ye, Lingman Ma
Summary: The article provides a comprehensive overview of mitotic catastrophe, a distinct form of cell death with unique nuclear alterations. It summarizes the anticancer drugs that induce mitotic catastrophe and evaluates its role in cancer treatment. The article also discusses strategies for overcoming its limitations and utilizing its advantages, as well as how mitotic catastrophe regulates cancer immunotherapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Review
Pharmacology & Pharmacy
Jelena Zivkovic, Kammala Ananth Kumar, Rapuru Rushendran, Kaliappan Ilango, Nouran M. Fahmy, Heba A. S. El-Nashar, Mohamed El-Shazly, Shahira M. Ezzat, Guiomar Melgar-Lalanne, Alejandra Romero-Montero, Sheila I. Pena-Corona, Gerardo Leyva-Gomez, Javad Sharifi-Rad, Daniela Calina
Summary: This review provides a comprehensive analysis of the pharmacological properties of mangiferin, focusing on its bioavailability and mechanisms of action, and its potential therapeutic applications in chronic diseases. It discusses the promising results observed in in vitro studies and clinical trials, but also highlights the challenges related to poor solubility and overall bioavailability that limit the application of mangiferin.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Cell Biology
Younis Ahmad Hajam, Raksha Rani, Shahid Yousuf Ganie, Tariq Ahmad Sheikh, Darakhshan Javaid, Syed Sanober Qadri, Sreepoorna Pramodh, Ahmad Alsulimani, Mustfa F. Alkhanani, Steve Harakeh, Arif Hussain, Shafiul Haque, Mohd Salim Reshi
Summary: This article discusses the mechanism of oxidative stress and its relationship with aging and related diseases.
Review
Pharmacology & Pharmacy
Jeremy Boulestreau, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Osteoarthritis is associated with a high number of senescent cells in joint tissues, which release senescence-associated secretory phenotype (SASP) factors contributing to the disease progression. Targeting senescent cells has shown improvement in OA features in mouse models. MSCs and MSC-EVs are promising treatments for OA, but their functions are affected by aging.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Pharmacology & Pharmacy
Zhifan Mao, Wenwen Liu, Yunyuan Huang, Tianyue Sun, Keting Bao, Jiali Feng, Alexey Moskalev, Zelan Hu, Jian Li
Summary: This study investigates the anti-aging effects of sulfonylurea drugs, specifically chlorpropamide, on various organisms. The findings suggest that chlorpropamide delays aging and reduces doxorubicin-induced senescence by interacting with mitochondrial ATP-sensitive K+ channels and mitochondrial complex II. The study also reveals that chlorpropamide increases mitochondrial reactive oxygen species levels, which are associated with longevity signals.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Geriatrics & Gerontology
Denis Golubev, Nadezhda Zemskaya, Oksana Shevchenko, Mikhail Shaposhnikov, Daria Kukuman, Sergey Patov, Vasily Punegov, Alexey Moskalev
Summary: This study found that Honeysuckle Lonicera pallasii extract and Cyanidin-3-O-glucoside (C3G) have antioxidant and anti-aging properties in red blood cells and Drosophila melanogaster models. They can extend lifespan, improve stress resistance, decrease locomotor activity, and enhance the integrity of the intestinal barrier. The effect of C3G may be associated with the activation of Sirt6. These findings suggest the potential benefits of Honeysuckle extract in improving healthspan.
Article
Cell Biology
Charles W. Beckett, Maria Victoria Niklison-Chirou
Summary: Depression is a common mental disorder affecting over 264 million people worldwide. Some depressed patients have excessive immune system activation, which suggests a sub-categorisation into inflammatory and non-inflammatory subtypes. Inflammatory depression, associated with raised inflammatory markers, is more likely to be treatment-resistant. Anti-inflammatory drugs, such as ketamine and Celecoxib, show promise in treating treatment-resistant depression.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
Dominic F. Bennett, Anita Goyala, Cyril Statzer, Charles W. Beckett, Alexander Tyshkovskiy, Vadim N. Gladyshev, Collin Y. Ewald, Joao Pedro de Magalhaes
Summary: Searching for drugs with similar gene expression patterns, rilmenidine was found to extend the lifespan of nematodes and rats, mediated by the I1-imidazoline receptor. This study suggests the potential of rilmenidine as a longevity-promoting drug.
Article
Geriatrics & Gerontology
Mikhail V. V. Shaposhnikov, Anastasia A. A. Gorbunova, Nadezhda V. V. Zemskaya, Natalia S. S. Ulyasheva, Natalya R. R. Pakshina, Daria V. V. Yakovleva, Alexey Moskalev
Summary: This study investigated the geroprotective effects of individual and simultaneous overexpression of genes encoding key enzymes of H2S biosynthesis on a Drosophila melanogaster model. Simultaneous overexpression of CBS and CSE showed additive effects in males and synergistic effects in females on median lifespan. Individual overexpression of CBS increased thermotolerance and decreased transcription levels of stress-responsive transcription factors HIF1 and Hsf, while individual overexpression of CSE increased paraquat resistance. Simultaneous overexpression of both genes increased resistance to hyperthermia in old females or paraquat in old males. The findings suggest a sex-specific epistatic interaction between CBS and CSE overexpression effects on longevity and stress resistance.
Letter
Gastroenterology & Hepatology
Daniil Rafaelevich Markaryan, Aleksandr Maksimovich Lukianov, Tatiana Nikolaevna Garmanova, Ekaterina Aleksandrovna Kazachenko, Aleksey Igorevich Moskalev, Bruno Roche
COLORECTAL DISEASE
(2023)
Article
Cell Biology
Elena Yushkova, Alexey Moskalev
Summary: Transposable elements (TEs) play a crucial role in eukaryotic genomes, impacting aging, carcinogenesis, and other age-related diseases. This review explores the fundamental properties of TEs and their complex interactions with cellular processes, highlighting their diverse effects on genetics and epigenetics. The review discusses TEs' interactions with recombination, replication, repair, and chromosomal regulation, their ability to balance activity and repression, their involvement in gene creation and RNA expression, and their role in DNA damage and regulatory networks. The review also evaluates the contribution of derepressed TEs to age-related effects in individual cells and tissues. Conflicting information about TE activity under stress and theories related to aging mechanisms are addressed. Furthermore, the review examines the specific impact of TEs on aging processes in germline and soma, as well as the regulation of TEs in cells. Recent findings on somatic mutations in human and animal tissues are discussed, focusing on their potential functional consequences. Additionally, the review explores the correlation between somatic TE activation and age-related changes in heterochromatin maintenance and longevity regulation. Notably, the review also explores the differences between transposon- and retrotransposon-mediated structural genome changes and their association with aging and age-related pathologies. Finally, based on published data, the review proposes a hypothesis regarding the influence of species-specific features of TE number, composition, and distribution on aging dynamics in different animal genomes.
AGEING RESEARCH REVIEWS
(2023)
Review
Nutrition & Dietetics
Anastasiia V. Badaeva, Alexey B. Danilov, Paul Clayton, Alexey A. Moskalev, Alexander V. Karasev, Andrey F. Tarasevich, Yulia D. Vorobyeva, Viacheslav N. Novikov
Summary: Neuronutrition is a part of nutritional neuroscience that studies the effects of different dietary components on behavior and cognition. It also encompasses the use of various nutrients and diets to prevent and treat neurological disorders. This narrative review explores the current understanding of neuronutrition as a key concept for brain health and its potential application in the prevention and treatment of various disorders.
Article
Biochemistry & Molecular Biology
Fedor I. I. Isaev, Arsenii R. R. Sadykov, Alexey Moskalev
Summary: Based on blood parameters, we investigated the influence of Kivach Clinic's special medical spa program on the biological age of patients. The results showed that the spa treatment has the potential to reduce biological age.
Article
Biotechnology & Applied Microbiology
A. P. Karmanov, L. S. Kocheva, O. V. Raskosha, A. A. Moskalev
Summary: This paper presents studies on the chemical and topological structure of lignin macromolecules from various herbaceous plants. The composition and properties of the biopolymers were determined using 13C-NMR spectroscopy, electron paramagnetic resonance, FTIR spectroscopy, and Py-GC/MS spectrometry. The results show that lignin from Rhodiola rosea belongs to the class of star-shaped polymers, and it has geroprotective properties and improves the cognitive abilities of model animals.
BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Daria V. Mikhailova, Oksana G. Shevchenko, Denis A. Golubev, Elena Y. Platonova, Nadezhda V. Zemskaya, Olesya Yu. Shoeva, Elena I. Gordeeva, Sergey A. Patov, Mikhail V. Shaposhnikov, Elena K. Khlestkina, Alexey Moskalev
Summary: This study examines the antioxidant and geroprotective properties of wheat bran extracts with high anthocyanin levels. The results show that the extracts with anthocyanins have higher radical scavenging and membrane protective activities, and can extend the lifespan of Drosophila. However, other metabolites in wheat bran may also contribute to its antioxidant and geroprotective potential.
Article
Cell Biology
Frank W. Pun, Geoffrey Ho Duen Leung, Hoi Wing Leung, Bonnie Hei Man Liu, Xi Long, Ivan Ozerov, Ju Wang, Feng Ren, Alexander Aliper, Evgeny Izumchenko, Alexey Moskalev, Joao Pedro de Magalhaes, Alex Zhavoronkov
Summary: Aging biology is a promising field, and this study proposes a list of novel aging-associated targets and classical targets for drug discovery and repurposing. Most of the top targets play a role in inflammation and extracellular matrix stiffness, highlighting the relevance of these processes in aging and age-related diseases. The PandaOmics platform demonstrates its application in target discovery across multiple disease areas.
Article
Cell Biology
Irina Strazhesko, Olga Tkacheva, Daria Kashtanova, Mikhail Ivanov, Vladislav Kljashtorny, Antonina Esakova, Maria Karnaushkina, Cassandra Guillemette, Amber Hewett, Veronique Legault, Lilit Maytesian, Maria Litvinova, Alan Cohen, Alexey Moskalev
Summary: Old age is a crucial risk factor for severe COVID-19, and physiological health status and biological age are important factors that affect COVID-19 severity and mortality. Certain physiological indicators can predict the deterioration and death risk of COVID-19. These findings have significant implications for the management of COVID-19 patients.
Article
Cell Biology
Esther Meron, Maria Thaysen, Suzanne Angeli, Adam Antebi, Nir Barzilai, Joseph A. Baur, Simon Bekker-Jensen, Maria Birkisdottir, Evelyne Bischof, Jens Bruening, Anne Brunet, Abigail Buchwalter, Filipe Cabreiro, Shiqing Cai, Brian H. Chen, Maria Ermolaeva, Collin Y. Ewald, Luigi Ferrucci, Maria Carolina Florian, Kristen Fortney, Adam Freund, Anastasia Georgievskaya, Vadim N. Gladyshev, David Glass, Tyler Golato, Vera Gorbunova, Jan Hoejimakers, Riekelt H. Houtkooper, Sibylle Jager, Frank Jaksch, Georges Janssens, Martin Borch Jensen, Matt Kaeberlein, Gerard Karsenty, Peter de Keizer, Brian Kennedy, James L. Kirkland, Michael Kjaer, Guido Kroemer, Kai-Fu Lee, Jean-Marc Lemaitre, David Liaskos, Valter D. Longo, Yu-Xuan Lu, Michael R. MacArthur, Andrea B. Maier, Christina Manakanatas, Sarah J. Mitchell, Alexey Moskalev, Laura Niedernhofer, Ivan Ozerov, Linda Partridge, Emmanuelle Passegue, Michael A. Petr, James Peyer, Dina Radenkovic, Thomas A. Rando, Suresh Rattan, Christian G. Riedel, Lenhard Rudolph, Ruixue Ai, Manuel Serrano, Bjoern Schumacher, David A. Sinclair, Ryan Smith, Yousin Suh, Pam Taub, Alexandre Trapp, Anne-Ulrike Trendelenburg, Dario Riccardo Valenzano, Kris Verburgh, Eric Verdin, Jan Vijg, Rudi G. J. Westendorp, Alessandra Zonari, Daniela Bakula, Alex Zhavoronkov, Morten Scheibye-Knudsen
Summary: Aging is the biggest risk factor for most chronic diseases, attracting attention from industry and investors. This year's ARDD meeting featured presentations from 75 speakers and included a longevity workshop to discuss aging mechanisms and potential modifications.
