Article
Chemistry, Multidisciplinary
Yafang Lu, Yuhan Shao, Weiwei Cui, Zhaoyu Jia, Qian Zhang, Qing Zhao, Zi-Jiang Chen, Junhao Yan, Bo Chu, Jia Yuan
Summary: The balance of redox homeostasis in the uterine epithelium is crucial for early pregnancy, and disruptions in this balance can lead to implantation defects and infertility in females. This study reveals the harmful effects of excessive lipid peroxides on embryo implantation and suggests that targeting the elimination of lipid peroxides may be a potential therapeutic approach. Administering lipid peroxidation inhibitors does not rescue implantation, but preserving a specific enzyme can restore reproductive capacity.
Article
Biochemistry & Molecular Biology
Xiao Ma, Jing Wang, Likai Wang, Laiqing Yan, Yunjie Liu, Wenkui Ma, Pengyun Ji, Lu Zhang, Guoshi Liu
Summary: Using Aanat and Mt2 KO mice, this study found that the melatonergic system plays a crucial role in early pregnancy in mice. The deficiency of AANAT and MT2 resulted in reduced implantation sites and abnormal endometrium morphology. Mechanistically, the melatonergic system is essential for normal endometrial receptivity and functions by activating the STAT signaling pathway. Melatonin production reduction and signal transduction impairment led to hyperproliferative endometrium and increased local immunoinflammatory reaction, causing early abortion in Mt2 KO mice. These findings might have implications in other animals, including humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Xu-Dong Zhang, Zhong-Yuan Liu, Mao-Sen Wang, Yu-Xiang Guo, Xiang-Kun Wang, Kai Luo, Shuai Huang, Ren-Feng Li
Summary: Regulation of cell mortality for disease treatment has been a focus of research, with the iron-dependent regulated cell death called Ferroptosis being extensively studied. Studies have shown that regulation of ferroptosis brings new treatment strategies for various diseases. Genes involved in iron and lipid metabolism can regulate ferroptosis by controlling iron overload and lipid peroxidation. Glutathione (GSH), the body's primary non-enzymatic antioxidant, also plays a crucial role in combating lipid peroxidation by assisting glutathione peroxidase 4 (GPX4). This review summarizes recent research on the mechanism of ferroptosis and comprehensively analyzes the regulation of ferroptosis through iron and lipid metabolism, as well as the metabolism of GPX4 and GSH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Obstetrics & Gynecology
Tianli Yang, Jing Zhao, Feng Liu, Yanping Li
Summary: This review summarizes the impact of lipid metabolism on reproductive health, particularly on endometrial receptivity and embryonic implantation. It discusses the role of various lipids and lipid-derived mediators in the processes and highlights emerging methods for evaluating endometrial receptivity.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Agriculture, Dairy & Animal Science
Claudia Lima Verde Leal, Karina Canon-Beltran, Yulia N. Cajas, Meriem Hamdi, Aracelli Yaryes, Maria Gemma Millan de la Blanca, Paula Beltran-Brena, Rosane Mazzarella, Juliano Coelho da Silveira, Alfonso Gutierrez-Adan, Encina M. Gonzalez, Dimitrios Rizos
Summary: This study aimed to evaluate the effect of extracellular vesicles (EVs) isolated from oviductal fluid (OF) and uterine fluid (UF) on the development and quality of bovine embryos in vitro. The results showed that the use of EVs improved blastocyst quality, including survival rate after vitrification/warming, total cell number, lipid content, and the expression of lipid metabolism-related genes. Additionally, the miRNA contents in EVs may contribute to these observed effects.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Reproductive Biology
Jiannan Li, Ruibin Wang, Qiang Chen, Yiqi Tian, Leilei Gao, Anmin Lei
Summary: Salidroside (SAL) improves the maturation and subsequent development of porcine oocytes by promoting lipid metabolism and providing energy, resulting in increased blastocyst formation rate and embryo quality.
Article
Agriculture, Dairy & Animal Science
Zhongyu Wang, Jiawei Feng, Chunxu Yang, Shaoyang Mou, Yingjie Xie, Xiaoxue Duan, Zhongyu Li, Zhongpeng Bi, Tianshu Liu, Feng Li, Liangmei Xu
Summary: This study investigated the effects of maternal dietary energy and arginine level on embryonic development and serum lipid metabolism. The results showed that maternal restricted feeding improved embryonic development and regulated lipid metabolism-related indices in embryonic serum. Additionally, the interaction between maternal dietary arginine and energy levels had a significant impact on embryo growth and development.
Article
Reproductive Biology
Guangzhu Dong, Rundong Sun, Rui Zhang, Yufeng Qin, Chuncheng Lu, Xinru Wang, Yankai Xia, Guizhen Du
Summary: Preimplantation triclosan exposure affects the receptivity of the endometrium by upregulating the expression of tight junction genes, thus reducing the rate of embryo implantation.
BIOLOGY OF REPRODUCTION
(2022)
Review
Biochemistry & Molecular Biology
Ji-Eun Kim, Jin-Sun Kim, Min-Jee Jo, Eunjung Cho, Shin-Young Ahn, Young-Joo Kwon, Gang-Jee Ko
Summary: This review summarizes the role of adipokines in the development of metabolic syndrome, with a focus on glucose homeostasis and lipid metabolism.
Article
Multidisciplinary Sciences
Xu Xiao, Youngjae Kim, Beatriz Romartinez-Alonso, Kristupas Sirvydis, Daniel S. Ory, John W. R. Schwabe, Michael E. Jung, Peter Tontonoz
Summary: Aster proteins mediate nonvesicular plasma membrane to endoplasmic reticulum cholesterol transport, with 20 alpha-hydroxycholesterol and U18666A identified as potential small molecule modulators. However, they target other sterol homeostatic proteins, limiting their utility.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Paulina Lipinska, Piotr Pawlak, Ewelina Warzych
Summary: Mammalian embryo development is influenced by several metabolic processes, particularly energy metabolism. The storage of lipids during preimplantation stages may affect the quality of embryos. This study aimed to characterize lipid droplets (LD) during different developmental stages in bovine and porcine embryos, as well as embryos from in vitro fertilization (IVF) and parthenogenetic activation (PA). The results showed that lipid parameters differed between IVF and PA bovine embryos at crucial stages of development, suggesting dysregulation of lipid metabolism in PA embryos. Additionally, bovine embryos exhibited higher lipid content during the early genome activation (EGA) stage and lower lipid content during the blastocyst stage compared to porcine embryos, indicating species-dependent energy demands. Overall, lipid droplet parameters vary significantly among developmental stages, species, and genome origin.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Sophea Heng, Nirukshi Samarajeewa, Asma Aberkane, Wafaa Essahib, Hilde Van de Velde, Maxine Scelwyn, M. Louise Hull, Beverley Vollenhoven, Luk J. Rombauts, Guiying Nie
Summary: This study found that PCX inhibits embryo implantation in vitro and in IVF patients. High levels of PCX significantly inhibited blastocyst attachment and penetration. The presence of PCX in the luminal epithelium was negatively associated with the success rate of clinical pregnancy.
FERTILITY AND STERILITY
(2021)
Review
Biochemistry & Molecular Biology
Qingyun Guan, Zixu Wang, Jing Cao, Yulan Dong, Yaoxing Chen
Summary: This review discusses the role of melatonin in regulating obesity-related symptoms and explores its underlying mechanisms. Melatonin plays an important role in regulating energy metabolism and antioxidant defense, and it may affect obesity through various pathways such as modulation of lipid profile, adipose tissue, and inflammation. Melatonin shows promising potential in the intervention of obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Dominique Delmas, Alexia K. Cotte, Jean-Louis Connat, Francois Hermetet, Florence Bouyer, Virginie Aires
Summary: Cancer cells have increased energy metabolism and alterations in lipid metabolism, which are important factors in tumor progression. Lipid droplets play a role in lipid storage and have multiple functions in cancer, including tumor progression and aggressiveness. Phosphatidylcholine metabolism and lipid synthesis enzymes are disrupted in many cancers, and tumor microenvironment conditions also affect lipid droplet behavior.
Article
Medicine, Research & Experimental
Yan Yin, Meade E. Haller, Sangappa B. Chadchan, Ramakrishna Kommagani, Liang Ma
Summary: Functional retinoic acid (RA) signaling is crucial for female fertility, especially implantation and decidualization, as shown by genetic mouse models and human endometrial stromal cell studies. Disruption of uterine RA signaling leads to compromised fertility due to failure of uterine receptivity and decidualization.
