期刊
TRANSPLANTATION
卷 106, 期 4, 页码 835-841出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0000000000004057
关键词
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资金
- Ben-Dov family
- Johns Hopkins COVID-19 Vaccine-related Research Fund
- National Cancer Institute [U54CA260491]
- National Institute of Diabetes and Digestive and Kidney Diseases [K23DK115908]
- National Institute of Allergy and Infectious Disease (NIAID) [K24AI144954, K08AI156021, U01AI138897, K23AI157893, R01AI120938S1]
- Division of Intramural Research, NIAID
This study found that prevaccination cytokine levels were associated with antibody response to SARS-CoV-2 vaccination in solid organ transplant recipients (SOTRs). The results suggest that a specific inflammatory profile may be associated with higher antibody responses in SOTRs after receiving a third dose of the vaccine.
Background. Solid organ transplant recipients (SOTRs) are at increased risk for severe COVID-19 and exhibit lower antibody responses to SARS-CoV-2 vaccines. This study aimed to determine if prevaccination cytokine levels are associated with antibody response to SARS-CoV-2 vaccination. Methods. A cross-sectional study was performed among 58 SOTRs before and after two-dose mRNA vaccine series, 35 additional SOTRs before and after a third vaccine dose, and comparison to 16 healthy controls (HCs). Antispike antibody was assessed using the IgG Euroimmun ELISA. Electrochemiluminescence detection-based multiplexed sandwich immunoassays (Meso Scale Diagnostics) were used to quantify plasma cytokine and chemokine concentrations (n = 20 analytes) and compare concentrations between SOTRs and HCs, stratified by ultimate antibody response to the vaccine using Wilcoxon-rank-sum test with false discovery rates computed to correct for multiple comparisons. Results. In the study population, 100% of HCs, 59% of SOTRs after 2 doses and 63% of SOTRs after 3 doses had a detectable antibody response. Multiple baseline cytokines were elevated in SOTRs versus HCs. There was no significant difference in baseline cytokine levels between SOTRs with high versus low-titer antibodies after 2 doses of vaccine. However, as compared with poor antibody responders, SOTRs who went on to develop a high-titer antibody response to a third dose of vaccine had significantly higher prethird dose levels of several innate immune cytokines including IL-17, IL-2Ra, IL-6, IP-10, MIP-1 alpha, and TNF-alpha (false discovery rates < 0.05). Conclusions. A specific inflammatory profile may be associated with developing higher antibodies in response to a third dose of SARS-CoV-2 vaccine in SOTRs.
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