Review
Immunology
Md Shamim Rahman, Heejin Jun
Summary: This review explains the impact of fat types and tissue microenvironment on energy expenditure, focusing on the role and regulation of macrophages in adaptive thermogenic fat.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Martha Hanschkow, Nathalie Boulet, Elena Kempf, Anne Bouloumie, Wieland Kiess, Robert Stein, Antje Korner, Kathrin Landgraf
Summary: MSCA1 and CD36 are associated with obesity-related alterations in children's adipose tissue, with CD36 expression predicting the adipogenic potential of SVF cells.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Ivonne Palacios-Marin, Dolors Serra, Josep. C. C. Jimenez-Chillaron, Laura Herrero, Marijana Todorcevic
Summary: Obesity is a major risk factor for type 2 diabetes and cardiovascular diseases. Childhood obesity is a concerning health challenge as it often persists into adulthood and increases the risk of morbidity and mortality. The mechanisms through which adipose tissue expands and its implications on metabolic health are still unclear, and more research is urgently needed to understand the development of adipose tissue in healthy and obese children.
Article
Biochemistry & Molecular Biology
Sarah Abdul Majeed, Helene Dunzendorfer, Juliane Weiner, John T. T. Heiker, Wieland Kiess, Antje Korner, Kathrin Landgraf
Summary: Obesity in children is associated with adipose tissue dysfunction and metabolic disease, increasing the risk of premature death. The brown adipose tissue (BAT), known for its energy-dissipating function, has been suggested to protect against obesity and metabolic dysfunction. Through genome-wide expression profiling, we identified several genes, including COBL, MKX, and MYOC, which have not been previously characterized in BAT biology and examined their functional role in BAT development. Our findings also reveal an association between the expression of these genes and early metabolic dysfunction in children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Francesca Sciarretta, Veronica Ceci, Marta Tiberi, Fabio Zaccaria, Haoyun Li, Zhong-Yan Zhou, Qiyang Sun, Daniels Konja, Alessandro Matteocci, Anup Bhusal, Martina Verri, Diego Fresegna, Sara Balletta, Andrea Ninni, Claudia Di Biagio, Marco Rosina, Kyoungho Suk, Diego Centonze, Yu Wang, Valerio Chiurchiu, Katia Aquilano, Daniele Lettieri-Barbato
Summary: Accumulating evidence suggests that dysfunctional adipose tissue (AT) plays a major role in the risk of developing multiple sclerosis (MS), the most common immune-mediated and demyelinating disease of the central nervous system. This study aimed at deciphering the responses of AT in experimental autoimmune encephalomyelitis (EAE), the best characterized animal model of MS. Through an integrative and multilayered approach, we identified lipocalin2 (LCN2) as the key molecule released by dysfunctional adipocytes through redox-dependent mechanism. Adipose-derived LCN2 shapes the pro inflammatory macrophage phenotype, and the genetic deficiency of LCN2 specifically in AT reduced weight loss as well as inflammatory macrophage infiltration in spinal cord in EAE mice. Mature adipocytes downregulating LCN2 reduced lipolytic response to inflammatory stimuli (e.g. TNFa) through an ATGL-mediated mechanism.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Takuya Sakurai, Toshiyuki Fukutomi, Sachiko Yamamoto, Eriko Nozaki, Takako Kizaki
Summary: The study found that the abnormal expression of fluid factors in the BAT of obese mice can be alleviated through physical activity, and Lgals3 and Lgals3bp may be involved in brown adipocyte differentiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Zhenlu Xu, Dongyun Liu, Dong Liu, Xue Ren, Haibo Liu, Guihong Qi, Yue Zhou, Chongming Wu, Kui Zhu, Zhongmei Zou, Jing Yuan, Wenhan Lin, Peng Guo
Summary: EQST, a meroterpenoid derived from a marine sponge-derived fungus, displays anti-obesity effects by inhibiting adipogenesis and regulating the enzyme activity of 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1). It shows better inhibitory intensity and efficacy on anti-obesity than known 11 beta-HSD1 inhibitors.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Cell Biology
Nadav Kislev, Shira Eidelheit, Shaked Perlmutter, Dafna Benayahu
Summary: In this study, a novel machine learning-based method was developed for analyzing lipid droplets (LDs) by segmenting phase-contrast images. This method enables accurate and label-free quantification of LD-related parameters and analysis of LD dynamics. It can be applied in different metabolic conditions to study LD biogenesis and function.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kathrin Landgraf, Andreas Kuhnapfel, Maria Schlanstein, Ronald Biemann, Berend Isermann, Elena Kempf, Holger Kirsten, Markus Scholz, Antje Korner
Summary: This study found that childhood obesity is associated with dysfunction and early signs of metabolic disease in adipose tissue. By analyzing gene expression profiles in adipose tissue samples from obese children, the researchers identified genes that are associated with obesity and related parameters. They also discovered that EGFL6 gene may play a role in the pathogenesis of metabolic disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Changbao Sun, Ang Li, Huan Wang, Jiage Ma, Juncai Hou
Summary: Acetate is associated with adipocyte differentiation and lipid deposition. In a study on obese mice and mouse adipose mesenchymal stem cells, it was found that acetate significantly increased body weight, food intake, and fatty lesions, while decreasing anti-inflammatory factors levels and liver function. The mRNA expression levels of several genes in adipose tissue and stem cells were also significantly altered.
Review
Endocrinology & Metabolism
Sufen Wang, Yifan Liu, Jiaqi Chen, Yuejing He, Wanrui Ma, Xinguang Liu, Xuerong Sun
Summary: Adipocytes have important roles in regulating nutrition, energy balance, metabolism, hormone secretion, and immune regulation. Different types of adipocytes contribute differently to the body, with white adipocytes storing energy, brown adipocytes generating heat, and beige adipocytes having the potential to produce heat.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Christy M. Gliniak, Line Pedersen, Philipp E. Scherer
Summary: The prevalence of obesity is increasing exponentially worldwide. The lack of effective long-term weight loss treatment options has made the problem even more significant. Research has shown that adipose tissue has a biological memory, which is a crucial determinant of long-term weight maintenance. Maladaptive cellular responses in adipose tissue lead to inflammation and fibrosis, explaining the link between obesity and insulin resistance, type 2 diabetes, cardiovascular disease, and fatty liver disease.
JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Cell Biology
Francesca Cinti, Saverio Cinti
Summary: This mini-review retraces the history of the adipose organ, discusses its role in diseases such as obesity and type 2 diabetes, and explores its relationship with COVID-19. It also provides therapeutic perspectives for these diseases.
Review
Cell Biology
Ursula White
Summary: White adipose tissue (WAT) expansion plays a crucial role in metabolic health, and impaired WAT expansion can lead to metabolic disorders. While increased hyperplasia is considered important for healthy WAT expansion, the role of adipogenesis remains debated. This mini-review will summarize recent developments and highlight the significance of WAT expansion in obesity and disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dan Xu, Ye Gong, Xiaojun Xiang, Yongtao Liu, Kangsen Mai, Qinghui Ai
Summary: This study discovered for the first time perirenal adipose tissue (PAT) in large yellow croaker, and observed its morphological and cytological characteristics. Compared with liver and muscle, PAT highly expressed marker genes of white adipose tissue. Preadipocytes were isolated from PAT and their differentiation process was investigated, revealing the regulation mechanism.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Maria J. Pereira, Johanna C. Andersson-Assarsson, Peter Jacobson, Prasad Kamble, Magdalena Taube, Kajsa Sjoholm, Lena M. S. Carlsson, Per-Arne Svensson
Summary: The study identified SLC19A3 as a novel adipose tissue-specific gene, with its expression regulated by body mass index and weight changes. This gene may play a key role in adipocyte metabolism.
OBESITY SCIENCE & PRACTICE
(2022)
Article
Endocrinology & Metabolism
Fozia Ahmed, Prasad G. Kamble, Susanne Hetty, Giovanni Fanni, Milica Vranic, Assel Sarsenbayeva, Robin Kristofi, Kristina Almby, Maria K. Svensson, Maria J. Pereira, Jan W. Eriksson
Summary: This study found that reduced estrogen levels in postmenopausal women can lead to metabolic side effects, particularly insulin resistance and type 2 diabetes. The results suggest that estrogen receptor expression in adipose tissue is lower in postmenopausal women, and E2 inhibits glucose utilization in human adipocytes. These findings may explain changes in glucose utilization after menopause and have implications for hormone treatment in postmenopausal women.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medical Laboratory Technology
Bipasha Nandi Jui, Assel Sarsenbayeva, Henning Jernow, Susanne Hetty, Maria J. Pereira
Summary: This study compared traditional RNA extraction with a column-based method and found that the traditional method provides sufficient RNA yield and integrity, which is advantageous for small adipose tissue specimens. The column-based method showed lower RNA quantity and integrity, although the differences were not statistically significant. It also had lower levels of contaminants.
LABORATORY MEDICINE
(2022)
Article
Biophysics
Alejandra N. Torres, Ludgero Tavares, Maria J. Pereira, Jan W. Eriksson, John G. Jones
Summary: This study characterized the fatty acid composition and positional distribution of triglycerides in human subcutaneous adipose tissue using C-13 NMR spectroscopy. The study found that the sn2 position of triglycerides is enriched with monounsaturated fatty acids, while the sn1,3 position is enriched with saturated fatty acids. Furthermore, the study revealed a significant positive correlation between palmitoleic acid levels and both BMI and insulin sensitivity.
NMR IN BIOMEDICINE
(2023)
Article
Medicine, General & Internal
Maria K. Svensson, Francesc Sorio Vilela, Margret Leosdottir, Jonas Banefelt, Maria Lindh, Alexander Rieem Dun, Anna Norhammar, Guillermo Villa
Summary: In recent years, there has been an increase in the proportion of post-myocardial infarction patients with high lipid-lowering treatment (LLT) intensity and adherence, with little change after transfer to primary care. The combination of LLT intensity and adherence is important for preventing future cardiovascular events.
UPSALA JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Giovanni Fanni, Petros Katsogiannos, Bipasha Nandi Jui, Magnus Sundbom, Susanne Hetty, Maria J. Pereira, Jan W. Eriksson
Summary: The study found that RYGB surgery can induce changes in insulin, hormones, and gut hormones in obese patients with type 2 diabetes, and these changes can last for at least 2 years.
ENDOCRINE CONNECTIONS
(2022)
Article
Medicine, General & Internal
Jan Melin, Maria K. Svensson, Bo Albinsson, Ola Winqvist, Karlis Pauksens
Summary: This study investigated the immune response of hemodialysis (HD) patients to the second and third doses of the SARS-CoV-2 BNT162b2 mRNA vaccine and found that the third dose led to a robust and improved immunological response. However, a few patients did not develop any antibody response, highlighting the need to monitor vaccine response and provide appropriate antibodies or antiviral drugs for non-responding patients.
UPSALA JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Maria J. Pereira, Ayesha Azim, Susanne Hetty, Bipasha Nandi Jui, Joel Kullberg, Martin H. Lundqvist, Jan W. Eriksson
Summary: This study aims to investigate the expression of interleukin-33 (IL-33) in subcutaneous adipose tissue (SAT) of type 2 diabetes (T2D) subjects and its effects on human adipocyte glucose uptake. The results showed that T2D subjects had higher IL-33 gene and protein expression in SAT, which was associated with insulin resistance and reduced gene expression of markers related to lipid storage and adipogenesis. Additionally, IL-33 treatment reduced adipocyte glucose uptake.
Article
Cell Biology
Milica Vranic, Fozia Ahmed, Susanne Hetty, Assel Sarsenbayeva, Vitor Ferreira, Giovanni Fanni, Angela M. Valverde, Jan W. Eriksson, Maria J. Pereira
Summary: We investigated the effects of second-generation antipsychotics (SGAs) on adipocyte differentiation and metabolism and found that aripiprazole (ARI) can impair adipocyte glucose uptake and increase fatty acid oxidation gene expression, while olanzapine (OLA) can increase leptin gene expression. These findings have important implications for understanding the metabolic effects of antipsychotic drugs and suggest that different SGAs may have different mechanisms of action.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Martin H. Lundqvist, Maria J. Pereira, Kristina Almby, Susanne Hetty, Jan W. Eriksson
Summary: Counter-regulatory hormonal responses to glucose variations differ in individuals with type 2 diabetes, prediabetes, and normoglycemia, and may contribute to the progression of the disease by promoting insulin resistance and dysglycemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Martin H. Lundqvist, Maria J. Pereira, Jan W. Eriksson
Summary: This study investigates whether inflammatory responses to glycemic and insulinemic variations are altered in obese individuals. The results show that hyperinsulinemia, hypoglycemia, and hyperglycemia lead to a decrease in multiple inflammatory markers, and the inflammatory response is more pronounced in obese individuals during hypoglycemia and hyperglycemia.
Article
Endocrinology & Metabolism
Fozia Ahmed, Milica Vranic, Susanne Hetty, Argyri Mathioudaki, Vagia Patsoukaki, Giovanni Fanni, Maria J. Pereira, Jan W. Eriksson
Summary: This study investigated the association of organic cation transporter 3 (OCT3) mRNA levels in subcutaneous adipose tissue with aging and markers of insulin resistance. The results showed that mRNA and protein levels of OCT3 increased with aging and were negatively associated with markers of insulin resistance. In addition, estradiol treatment resulted in a reduction in OCT3 mRNA levels.
Article
Endocrinology & Metabolism
Milica Vranic, Fozia Ahmed, Robin Kristofi, Susanne Hetty, Dariush Mokhtari, Maria K. Svensson, Jan W. Eriksson, Maria J. Pereira
Summary: This study evaluates the dopaminergic signaling in human adipose tissue in the context of obesity and type 2 diabetes (T2D) and its potential implications in adipose tissue metabolism. The results suggest that protein expression of DRD2 in subcutaneous adipose tissue is up-regulated with hyperglycemia and T2D, possibly as a compensatory mechanism. Additionally, dopamine receptor agonists inhibit adipocyte lipolysis and may have beneficial effects on lipid metabolism.
Article
Cardiac & Cardiovascular Systems
Ulf Landmesser, Peter Lindgren, Emil Hagstrom, Ben van Hout, Guillermo Villa, Peter Pemberton-Ross, Jorge Arellano, Maria Eriksson Svensson, Mahendra Sibartie, Gregg C. Fonarow
Summary: This study assessed the cost-effectiveness of adding proprotein convertase subtilisin/kexin type 9 inhibition with evolocumab to standard lipid-lowering treatment in Swedish patients with a history of myocardial infarction. The findings suggest that this treatment strategy is cost-effective in Sweden at specific LDL-C levels.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)