Article
Multidisciplinary Sciences
Edward Spinard, Vivian O'Donnell, Elizabeth Vuono, Ayushi Rai, Charronne Davis, Elizabeth Ramirez-Medina, Nallely Espinoza, Alyssa Valladares, Manuel V. Borca, Douglas P. P. Gladue
Summary: African swine fever, a lethal disease of domestic pigs, has reappeared in the Dominican Republic after more than 40 years of absence in the Western hemisphere. This recent outbreak strain, identified as a genotype II ASFV, has close relation to the ASF strains circulating in Asia and Europe.
SCIENTIFIC REPORTS
(2023)
Article
Veterinary Sciences
Rachel Schambow, Raysa Reyes, Jose Morales, Alan Diaz, Andres M. Perez
Summary: Since the reintroduction of African swine fever in the Dominican Republic in July 2021, strategies for its control have been discussed. This study used SWOT analysis to evaluate three different theoretical ASF control scenarios and considered various aspects of the issue.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Infectious Diseases
Carola Sauter-Louis, Katja Schulz, Michael Richter, Christoph Staubach, Thomas C. Mettenleiter, Franz J. Conraths
Summary: The study compared the epidemiological course of African swine fever in Germany, Czech Republic, and Belgium in the first 6 months since its introduction. Germany had more cases and a larger affected area compared to Czech Republic and Belgium. Germany experienced multiple independent introductions, while Czech Republic and Belgium only had single introductions.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Virology
Elizabeth Ramirez-Medina, Vivian O'Donnell, Ediane Silva, Nallely Espinoza, Lauro Velazquez-Salinas, Karen Moran, Dee Ann Daite, Roger Barrette, Bonto Faburay, Robin Holland, Douglas P. Gladue, Manuel Borca
Summary: This study observed the clinical presentation of an ASFV field strain isolated from the Dominican Republic in domestic pigs. The results showed that the virus caused varying degrees of disease, with some animals experiencing acute fatal forms and others presenting with mild transient diseases. Additionally, all infected animals developed a strong antibody response.
Article
Agronomy
Elzbieta Jadwiga Szymanska, Mariusz Dziwulaki
Summary: African swine fever poses a major problem in pig production in Poland, with wild boars and human activity being the main causes of virus transmission. This research shows that the disease has a certain periodicity in the country, and despite actions taken, it spreads rapidly.
Review
Biology
Zhaoyao Li, Wenxian Chen, Zilong Qiu, Yuwan Li, Jindai Fan, Keke Wu, Xiaowen Li, Mingqiu Zhao, Hongxing Ding, Shuangqi Fan, Jinding Chen
Summary: African swine fever is a highly fatal viral disease in domestic pigs and wild boars, impacting pig-raising countries and pork trade. Safe and effective vaccines are urgently needed to control outbreaks. Understanding the structure, function, immune response, and diagnosis of the ASF virus is crucial for vaccine development.
Article
Immunology
Siqi Cai, Zezhong Zheng, JiaoJiao Cheng, Lintao Zhong, Ran Shao, Feiyan Zheng, Zhiying Lai, Jiajun Ou, Liang Xu, Pei Zhou, Gang Lu, Guihong Zhang
Summary: This study identified swine interferon-induced transmembrane proteins (SwIFITMs) as having potent antiviral activity against African swine fever virus (ASFV). These proteins were found to be constitutively expressed in most porcine tissues and their expression levels were induced by ASFV infection or swine interferon treatment. Overexpression of SwIFITMs inhibited ASFV replication in Vero cells, while knockdown of these genes enhanced ASFV replication in PAMs. The study also demonstrated that endogenous IFITMs play a role in restricting ASFV replication. Overall, this research expands our understanding of the antiviral activity of porcine IFITMs against ASFV.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Ulaankhuu Ankhanbaatar, Tserenchimed Sainnokhoi, Buyantogtokh Khanui, Gerelmaa Ulziibat, Tserenjav Jargalsaikhan, Dulam Purevtseren, Tirumala Bharani K. Settypalli, John Flannery, William G. Dundon, Ganzorig Basan, Carrie Batten, Giovanni Cattoli, Charles E. Lamien
Summary: African swine fever (ASF) is a severe haemorrhagic disease of pigs caused by the ASFV virus, which has spread to Europe and Asia. Mongolia reported its first outbreak on January 15th, 2019, becoming the second country in the region affected by the disease after China. The Mongolian ASFV belong to genotype II and serogroup 8, indicating a possible cross-border spread of the virus.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Virology
Yanyan Zhang, Junnan Ke, Jingyuan Zhang, Jinjin Yang, Huixian Yue, Xintao Zhou, Yu Qi, Rongnian Zhu, Faming Miao, Qian Li, Fei Zhang, Ying Wang, Xun Han, Lijuan Mi, Jinmei Yang, Shoufeng Zhang, Teng Chen, Rongliang Hu
Summary: African swine fever (ASF) is a severe infectious disease in pigs caused by ASFV, with no commercial vaccine available. A new vaccine candidate named SY18DI226R has been identified, showing promising results in eliciting immunity to virulent ASFV infection in pigs.
JOURNAL OF VIROLOGY
(2021)
Article
Veterinary Sciences
Taehwan Oh, Duy Tien Do, Hung Van Vo, Hyeok-il Kwon, Seung-Chul Lee, Min Ho Kim, Dung Thi Thu Nguyen, Quang Tin Vinh Le, Tan Minh Tran, Toan Tat Nguyen, Joo Young Lee, Chanhee Chae
Summary: The use of renal-derived swine macrophages as a novel primary cell candidate offers a solution to ethical constraints and consistency problems in ASFV propagation. These primary cells are proven to be permissive to both cell adapted ASFV and wild-type ASFV, making them useful for virus isolation and propagation. Additionally, compared to commercial cell lines, renal-derived macrophages demonstrate consistent molecular characteristics and are more suitable for isolating field viruses.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Immunology
Jan H. Forth, Sten Calvelage, Melina Fischer, Jan Hellert, Julia Sehl-Ewert, Hanna Roszyk, Paul Deutschmann, Adam Reichold, Martin Lange, Hans-Hermann Thulke, Carola Sauter-Louis, Dirk Hoper, Svitlana Mandyhra, Maryna Sapachova, Martin Beer, Sandra Blome
Summary: African swine fever virus (ASFV) is a large and complex DNA virus that circulates between soft ticks and indigenous suids in sub-Saharan Africa. It has recently spread from Europe to Asia, causing severe haemorrhagic disease with high lethality rates in wild boar and domestic pigs. ASFV has shown high genetic stability for over a decade, making it difficult to trace outbreaks and conduct genomic surveillance. However, during its incursion into Germany in 2020, ASFV unexpectedly diverged into five distinct lineages with unique mutations. This new finding suggests a potential impact on the course of the ASFV pandemic.
EMERGING MICROBES & INFECTIONS
(2023)
Review
Virology
Maria Serena Beato, Federica D'Errico, Carmen Iscaro, Stefano Petrini, Monica Giammarioli, Francesco Feliziani
Summary: African Swine Fever (ASF) is a highly lethal disease in suids that is transmitted through direct and indirect contact with infected animals and contaminated objects. The spread of ASF in Europe has revealed gaps in our understanding of transmission mechanisms. Due to the lack of vaccines, biosecurity measures and cleaning and disinfection procedures are essential for controlling the spread of ASF in pig farms.
Review
Agriculture, Dairy & Animal Science
Silvia Pavone, Carmen Iscaro, Annalisa Dettori, Francesco Feliziani
Summary: African swine fever is a severe viral disease caused by the African swine fever virus, with 24 genotypes reported in sub-Saharan Africa. Italy has experienced two ASF epidemics, with four ongoing infection clusters.
Article
Immunology
Maksym Bezymennyi, Oleksandr Tarasov, Ganna V. Kyivska, Nataliia A. Mezhenska, Svitlana Mandyhra, Ganna Kovalenko, Mykola Sushko, Nataliia Hudz, Serhii V. Skorokhod, Roman Datsenko, Larysa Muzykina, Elaina Milton, Maryna A. Sapachova, Serhii Nychyk, Ihor Halka, Maciej Frant, Falk Huettmann, Devin M. Drown, Anton Gerilovych, Andrii A. Mezhenskyi, Eric Bortz, Christian E. Lange
Summary: African swine fever (ASF) is a viral disease that originated in Africa and has spread to Europe and Asia, causing high mortality in domestic pig populations. In Ukraine, ASF outbreaks have been reported since 2012, with the highest numbers in 2017 and 2018. The spread of ASF in Ukraine shows a directional pattern from the eastern and northern borders towards the western and southern regions, and wild boars may have played a role in the early spread. However, human activity is now the main driver of spread, and effective mitigation strategies have led to a decline in outbreaks since 2019.
Article
Veterinary Sciences
Suphachai Nuanualsuwan, Tapanut Songkasupa, Prakit Boonpornprasert, Nutthakarn Suwankitwat, Walaiporn Lohlamoh, Chackrit Nuengjamnong
Summary: The African swine fever virus can be indirectly transmitted through contaminated objects, feed, pork, and pig products. Heat treatment of swill can effectively eliminate the virus, but there are inconsistent recommendations regarding the temperature and time of heat treatment. This study assessed the thermal inactivation of ASFV in different swill formulae and developed a model to predict inactivation at other temperatures.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Infectious Diseases
Rachel A. Schambow, Fernando Sampedro, Pedro E. Urriola, Jennifer L. G. van de Ligt, Andres Perez, Gerald C. Shurson
Summary: A quantitative risk assessment model was developed to estimate the probability of ASFV-contaminated corn or soybean meal ocean vessels being imported into the United States annually. The model considered different likelihood conditions and found that recontamination had a significant impact on the risk of ASFV-contaminated soybean meal vessels entering the United States.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Infectious Diseases
Joseph Nkamwesiga, Fedor Korennoy, Paul Lumu, Peninah Nsamba, Frank Nobert Mwiine, Kristina Roesel, Barbara Wieland, Andres Perez, Henry Kiara, Dennis Muhanguzi
Summary: Peste des Petits Ruminants (PPR) is a highly contagious and fatal disease that affects small ruminants globally. This study in Uganda identified the trends and drivers of PPR outbreaks using outbreak data from 2007 to 2020. The study found that inter-district and cross-border animal movement, along with certain environmental factors, contribute to the spread of PPR. The findings highlight the importance of prioritizing vaccination in new hotspot areas to prevent further transmission.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
News Item
Infectious Diseases
S. B. Tyulegenov, A. Zhakupbayev, M. Berdikulov, T. Karibayev, G. N. Yessembekova, A. A. Sultanov, A. M. Perez, S. K. Abdrakhmanov
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
