期刊
TOXICOLOGY LETTERS
卷 350, 期 -, 页码 213-224出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2021.07.004
关键词
Implants; Metal toxicity; Metal ion concentration ranges; Systemic effects of metal ions
类别
资金
- Blazer Foundation for Regenerative Medicine and Disability Research (RMDR) Lab
- Nanomedicine Lab at the Department of Biomedical Sciences
- UIC College of Medicine at Rockford
- NIHR03 [R03NS111554]
Metal-based implants and prostheses have been used for over a century, but concerns regarding potential toxicity and complications have arisen. Systemic toxicity is a major factor contributing to rejection and revision of implants.
The metal/metal alloy-based implants and prostheses are in use for over a century. and the rejections. revisions, and metal particle-based toxicities were reported concurrently. Complications developed due to metal ions, metal debris, and organo-metallic particles in orthopedic patients have been a growing concern in recent years. It was reported that local and systemic toxicity caused by such released products from the implants is one of the major reasons for implant rejection and revision. Even though the description of environmental metal toxicants and safety limits for their exposure to humans were well established in the literature, an effort was not adequately performed in the case of implant-based metal toxicology. Since the metal ion concentration in serum acts as a possible indicator of the systemic toxicity, this review summarizes the reported human serum safe limits, toxic limits, and concentration range (mu g/L, ppb, etc.) for mild to severe symptoms of six (cardiac. hepatic, neuro, nephron, dermal and endocrine) systemic toxicities for twelve most commonly used metallic implants. It also covers the widely used metal ion quantification techniques and systemic toxicity treatments reported. (C) 2021 Published by Elsevier B.V.
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