Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein

(2020) Shuai Xia et al.   Cellular & Molecular Immunology

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China

(2020) Dawei Wang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

First Case of 2019 Novel Coronavirus in the United States

(2020) Michelle L. Holshue et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2

(2020)   Nature Microbiology

Computational Design of ACE2-Based Peptide Inhibitors of SARS-CoV-2

(2020) Yanxiao Han et al.   ACS Nano

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

(2020) Shuai Xia et al.   CELL RESEARCH

Middle East Respiratory Syndrome-Coronavirus Infection into Established hDPP4-Transgenic Mice Accelerates Lung Damage Via Activation of the Pro-Inflammatory Response and Pulmonary Fibrosis

(2020) Ju Kim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Design of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity

(2020) Yuanmei Zhu et al.   JOURNAL OF VIROLOGY

World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19)

(2020) Catrin Sohrabi et al.   International Journal of Surgery

De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2

(2020) Xiaoqiang Huang et al.   Aging-US

Efficacy and safety of interferon β-1a in treatment of severe COVID-19: A randomized clinical trial

(2020) Effat Davoudi-Monfared et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clinical trials of repurposed antivirals for SARS-CoV-2

(2020) Miguel Angel Martinez   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Snake venom‐derived bradykinin‐potentiating peptides: A promising therapy for COVID ‐19?

(2020) Ahmed S. Gouda et al.   DRUG DEVELOPMENT RESEARCH

Clinical trials for the prevention and treatment of COVID ‐19: current state of play

(2020) Joshua S Davis et al.   MEDICAL JOURNAL OF AUSTRALIA

In silico design of antiviral peptides targeting the spike protein of SARS-CoV-2

(2020) Rongsong Ling et al.   PEPTIDES

Identification of a Potential Peptide Inhibitor of SARS-CoV-2 Targeting its Entry into the Host Cells

(2020) Mirza S. Baig et al.   DRUGS IN R&D

Contriving Multi-Epitope Subunit of Vaccine for COVID-19: Immunoinformatics Approaches

(2020) Rong Dong et al.   Frontiers in Immunology

Effect of Remdesivir vs Standard Care on Clinical Status at 11 Days in Patients With Moderate COVID-19

(2020) Christoph D. Spinner et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A broad-spectrum virus- and host-targeting peptide against respiratory viruses including influenza virus and SARS-CoV-2

(2020) Hanjun Zhao et al.   Nature Communications

Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2

(2020) Lili Wu et al.   Cell Discovery

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

(2019) Shuai Xia et al.   Science Advances

Human Antimicrobial Peptides as Therapeutics for Viral Infections

(2019) Aslaa Ahmed et al.   Viruses-Basel

Cell penetrating peptides: the potent multi-cargo intracellular carriers

(2019) Kimia Kardani et al.   Expert Opinion on Drug Delivery

The human coronavirus HCoV‐229E S‐protein structure and receptor binding

(2019) Zhijie Li et al.   eLife

Therapeutic peptides: Historical perspectives, current development trends, and future directions

(2018) Jolene L. Lau et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Peptide chemistry toolbox – Transforming natural peptides into peptide therapeutics

(2018) Miloš Erak et al.   BIOORGANIC & MEDICINAL CHEMISTRY

HPEPDOCK: a web server for blind peptide–protein docking based on a hierarchical algorithm

(2018) Pei Zhou et al.   NUCLEIC ACIDS RESEARCH

Antimicrobial Peptides

(2018) Donald E. Fry   Surgical Infections

Recombinant Interferons Beta-1a and Beta-1b: Protein Structural Features and Problematic Issues with Identity Confirmation

(2018) E. O. Goloshchapova et al.   PHARMACEUTICAL CHEMISTRY JOURNAL

Defensins in Viral Infection and Pathogenesis

(2017) Mayumi K. Holly et al.   Annual Review of Virology

Pre-fusion structure of a human coronavirus spike protein

(2016) Robert N. Kirchdoerfer et al.   NATURE

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

APD3: the antimicrobial peptide database as a tool for research and education

(2015) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond

(2015) Guangwen Lu et al.   TRENDS IN MICROBIOLOGY

CancerPPD: a database of anticancer peptides and proteins

(2014) Atul Tyagi et al.   NUCLEIC ACIDS RESEARCH

AVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses

(2013) Abid Qureshi et al.   NUCLEIC ACIDS RESEARCH

AVPpred: collection and prediction of highly effective antiviral peptides

(2012) Nishant Thakur et al.   NUCLEIC ACIDS RESEARCH

Antimicrobial peptides important in innate immunity

(2011) Andreas Cederlund et al.   FEBS Journal

Inhibition of SARS Pseudovirus Cell Entry by Lactoferrin Binding to Heparan Sulfate Proteoglycans

(2011) Jianshe Lang et al.   PLoS One

Recently Discovered Human Coronaviruses

(2009) Brigitte A. Wevers et al.   CLINICS IN LABORATORY MEDICINE

Argininosuccinate Synthetase Is a Functional Target for a Snake Venom Anti-hypertensive Peptide

(2009) Juliano R. Guerreiro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhesus Theta-Defensin Prevents Death in a Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Pulmonary Disease

(2009) C. L. Wohlford-Lenane et al.   JOURNAL OF VIROLOGY