期刊
INTERNAL MEDICINE
卷 55, 期 10, 页码 1345-1349出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.55.5997
关键词
adult T cell leukemia / lymphoma (ATL); C-C chemokine receptor type 4 (CCR4); regulatory T cell (Treg); psoriasis vulgaris; autoinflammatory disease
Adult T cell leukemia / lymphoma (ATL) is one of the most aggressive hematological malignancies caused by human T-lymphotropic virus type-I (HTLV-1). Mogamulizumab is a new defucosylated humanized monoclonal antibody agent which targets C-C chemokine receptor type 4 (CCR4) expressed occasionally on the surface of ATL cells. However, adverse events such as drug eruptions have also been highlighted, at least in part, via the dysfunction of regulatory T cells (Tregs). We herein report a pronounced recurrence of systemic psoriasis vulgaris accompanied by the treatment of mogamulizumab in a patient with ATL. Pathological examinations may suggest a mechanistic link between the recurrence of autoinflammatory diseases and anti-CCR4 antibody therapies.
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