Article
Medicine, General & Internal
Alper Tuna Guven, Murat Ozdede, Yusuf Ziya Sener, Ali Osman Yildirim, Sabri Engin Altintop, Berkay Yesilyurt, Oguz Abdullah Uyaroglu, Mine Durusu Tanriover
Summary: This study aimed to evaluate the performance of machine learning algorithms in identifying and predicting renal adverse events associated with RAASi. The most important features for predicting these events were found to be index K and glucose levels, as well as uncontrolled diabetes mellitus. kNN, RF, xGB, and NN algorithms showed the highest performance metrics for prediction.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Federica Toto, Elisabetta Salvioni, Damiano Magri, Susanna Sciomer, Massimo Piepoli, Roberto Badagliacca, Arianna Galotta, Nikita Baracchini, Stefania Paolillo, Ugo Corra, Rosa Raimondo, Rocco Lagioia, Pasquale Perrone Filardi, Annamaria Iorio, Michele Senni, Michele Correale, Mariantonietta Cicoira, Enrico Perna, Marco Metra, Marco Guazzi, Giuseppe Limongelli, Gianfranco Sinagra, Gianfranco Parati, Gaia Cattadori, Francesco Bandera, Maurizio Bussotti, Massimo Mapelli, Manlio Cipriani, Alice Bonomi, Goncalo Cunha, Federica Re, Carlo Vignati, Andrea Garascia, Carlo Lombardi, Angela B. Scardovi, Andrea Passantino, Michele Emdin, Claudio Passino, Caterina Santolamazza, Davide Girola, Denise Zaffalon, Dario Vizza, Fabiana De Martino, Piergiuseppe Agostoni
Summary: This study aimed to assess the prognostic impact of moderate hyperkalemia in chronic HFrEF patients and found that it does not influence patients' outcome.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Zhun-Yong Gu, Wen-Jun Liu, Dan-Lei Huang, Yu-Jing Liu, Hong-Yu He, Cheng Yang, Yi-Mei Liu, Ming Xu, Rui-Ming Rong, Du-Ming Zhu, Zhe Luo, Min-Jie Ju
Summary: This study evaluated the effect of combining clindamycin with low-dose trimethoprim-sulfamethoxazole (TMP/SMX) regimen on severe Pneumocystis pneumonia (PCP) after renal transplantation. The results showed that the combination therapy significantly improved the PaO2/FiO2 ratio, reduced the incidence of pneumomediastinum, and shortened the length of hospital and ICU stay compared to the standard dose of TMP/SMX treatment. Moreover, the combination therapy had a lower adverse reaction rate and reduced the dosage of TMP/SMX in patients.
FRONTIERS IN MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Fei Qin, Jianling Li, Yong-Fa Dai, Xiao-ge Zhong, Ya-jin Pan
Summary: The study demonstrated that renal denervation reduces levels of RAAS components such as aldosterone and Ang II, leading to lower blood pressure and improved renal function.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Transplantation
Y. Joseph Hwang, Flory T. Muanda, Eric McArthur, Matthew A. Weir, Jessica M. Sontrop, Ngan N. Lam, Amit X. Garg
Summary: This study assessed the risk of hyperkalemia after treatment with TMP-SMX compared to amoxicillin and found that the risk was higher in patients with lower eGFR. TMP-SMX was associated with a higher risk of AKI and all-cause hospitalization compared to amoxicillin.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Infectious Diseases
Toshinori Hirai, Ryosuke Yamaga, Yutori Ishikawa, Kazuhiko Hanada, Takuya Iwamoto, Toshimasa Itoh
Summary: High-dose sulfamethoxazole/trimethoprim is a significant predictor of hyperkalemia, while the effect of glucocorticoids on hyperkalemia varies depending on the dose of sulfamethoxazole/trimethoprim.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Gregory L. Hundemer, Manish M. Sood
Summary: RAAS inhibitors are evidence-based treatments for various conditions, but can lead to hyperkalemia, which increases the risk for cardiovascular events. Managing hyperkalemia while maintaining the benefits of RAAS inhibitors is essential to prevent adverse outcomes.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Chu-Hsuan Chiu, Chin-Feng Hsuan, Shih-Hua Lin, Yi-Jen Hung, Chii-Min Hwu, Siow-Wey Hee, Shu-Wha Lin, Sitt-Wai Fong, Patrick Ching-Ho Hsieh, Wei-Shun Yang, Wei-Chou Lin, Hsiao-Lin Lee, Meng-Lun Hsieh, Wen-Yi Li, Jou-Wei Lin, Chih-Neng Hsu, Vin-Cent Wu, Gwo-Tsann Chuang, Yi-Cheng Chang, Lee-Ming Chuang
Summary: Genetic variants of the RRBP1 gene have been found to be associated with blood pressure variation. Deficiency of RRBP1 can lead to lower blood pressure, hyperkalemia, and sudden cardiac death.
JOURNAL OF BIOMEDICAL SCIENCE
(2023)
Article
Toxicology
Chenpeng Zhu, Weikuan Gu, Dianjun Sun, Wei Wei
Summary: The renin-angiotensin system (RAS) plays a crucial role in regulating blood pressure. Excess fluoride can increase blood pressure by dysregulating the RAS. The study found that fluoride reduces levels of renin, angiotensin II (Ang II), and angiotensin (1-7) [Ang (1-7)], and disrupts the balance of aldosterone and potassium levels. Excess fluoride also damages the kidneys, myocardium, and aorta, and affects the activation of different components of the RAS, leading to hypertension with low renin levels.
TOXICOLOGY LETTERS
(2023)
Article
Medicine, General & Internal
Vincenzo Calabrese, Valeria Cernaro, Valeria Battaglia, Guido Gembillo, Elisa Longhitano, Rossella Siligato, Giovanna Sposito, Guido Ferlazzo, Domenico Santoro
Summary: This observational study aimed to verify the association between serum potassium levels and hospitalization days in patients with chronic kidney disease. The results showed that hyperkalemia is an independent risk factor for increased length of hospital stay, particularly in patients with stage G4-G5 chronic kidney disease.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Shun Kohsaka, Suguru Okami, Naru Morita, Toshitaka Yajima
Summary: This study investigated the clinical challenge of continuing renin-angiotensin-aldosterone system inhibitor (RAASi) therapy in hyperkalemic patients with heart failure (HF) and evaluated the impact of cessation on the risk-benefit balance. The findings suggest that the risks of discontinuing RAASi/MRA therapy may outweigh the benefits in patients with mild to moderate hyperkalemia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Jaejin An, Hui Zhou, Liang Ni, Teresa N. Harrision, Rong Wei, Abiy Agiro, Yasmin Ghanshyam Brahmbhatt, Yemmie Oluwatosin, Craig Schilling, John J. Sim
Summary: Discontinuation of RAASi after hyperkalemia is associated with worsened mortality, highlighting the benefits of continuing RAASi among patients with CKD.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Anna Oliveras, Susana Vazquez, Maria Jose Soler, Isabel Galceran, Xavier Duran, Albert Goday, David Benaiges, Marta Crespo, Julio Pascual, Marta Riera
Summary: Obesity-related hyperfiltration causes an increase in GFR and hyperalbuminuria, which can be reversed after bariatric surgery. Body weight and aldosterone are the main factors mediating changes in eGFR in obesity and bariatric surgery, while albuminuria is associated with glucose homeostasis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Kazumichi Fujioka, Ruka Nakasone, Kosuke Nishida, Mariko Ashina, Itsuko Sato, Kandai Nozu
Summary: Pseudohypoaldosteronism type 1 (PHA-1) is a disorder characterized by sodium regulation problems due to renal tubular resistance to aldosterone. This study conducted a nationwide surveillance of neonatal PHA-1 in Japan, revealing its higher prevalence among preterm infants without male predominance and immediate onset after birth in cases without genetic or renal complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Susanne Rysz, Jonathan Al-Saadi, Anna Sjostrom, Maria Farm, Francesca Campoccia Jalde, Michael Platten, Helen Eriksson, Margareta Klein, Roberto Vargas-Paris, Sven Nyren, Goran Abdula, Russell Ouellette, Tobias Granberg, Malin Jonsson Fagerlund, Johan Lundberg
Summary: Studies suggest that RAAS imbalance worsens the prognosis in COVID-19 patients, and experiments in pigs show that over-activation of ACE2 and RAAS can lead to a disease state similar to COVID-19 in humans. Imbalanced RAAS state in animals can be ameliorated by angiotensin receptor blockers and low-molecular-weight heparin.
NATURE COMMUNICATIONS
(2021)