Ubiquitin E3 Ligase LNX2 is Critical for Osteoclastogenesis In Vitro by Regulating M-CSF/RANKL Signaling and Notch2

Downregulation of Notch Modulators, Tetraspanin 5 and 10, Inhibits Osteoclastogenesis in Vitro

(2014) Jian Zhou et al.   CALCIFIED TISSUE INTERNATIONAL

Osteoclast-Derived Coupling Factors in Bone Remodeling

(2013) Kim Henriksen et al.   CALCIFIED TISSUE INTERNATIONAL

Numb Inhibits the Recycling of Sanpodo in Drosophila Sensory Organ Precursor

(2013) Mathieu Cotton et al.   CURRENT BIOLOGY

Numb Localizes at Endosomes and Controls the Endosomal Sorting of Notch after Asymmetric Division in Drosophila

(2013) Lydie Couturier et al.   CURRENT BIOLOGY

Notch signaling at a glance

(2013) K. Hori et al.   JOURNAL OF CELL SCIENCE

Osteopetrosis: genetics, treatment and new insights into osteoclast function

(2013) Cristina Sobacchi et al.   Nature Reviews Endocrinology

Notch Signaling and Bone Remodeling

(2013) Jenna Regan et al.   Current Osteoporosis Reports

Calcium/calmodulin-dependent protein kinase IV (CaMKIV) enhances osteoclast differentiation via the up-regulation of Notch1 protein stability

(2012) Yun-Hee Choi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Osteoclast Fusion and Fission

(2012) Ineke D. C. Jansen et al.   CALCIFIED TISSUE INTERNATIONAL

Notch Signaling: Numb Makes the Difference

(2012) Bernd Giebel et al.   CURRENT BIOLOGY

Endocytosis and control of Notch signaling

(2012) Vasundhara Kandachar et al.   CURRENT OPINION IN CELL BIOLOGY

Osteoblast Lineage-Specific Effects of Notch Activation in the Skeleton

(2012) Ernesto Canalis et al.   ENDOCRINOLOGY

Interaction of Notch Signaling Modulator Numb with α-Adaptin Regulates Endocytosis of Notch Pathway Components and Cell Fate Determination of Neural Stem Cells

(2012) Yan Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomics Strategy to Identify Substrates of LNX, a PDZ Domain-containing E3 Ubiquitin Ligase

(2012) Zhengguang Guo et al.   JOURNAL OF PROTEOME RESEARCH

New insights into osteoclastogenic signaling mechanisms

(2012) Tomoki Nakashima et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8  and promote its ubiquitylation and endocytosis

(2011) M. D'Agostino et al.   JOURNAL OF CELL SCIENCE

Osteoporosis: now and the future

(2011) Tilman D Rachner et al.   LANCET

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

(2011) Michael A Simpson et al.   NATURE GENETICS

LIS1 Regulates Osteoclast Formation and Function through Its Interactions with Dynein/Dynactin and Plekhm1

(2011) Shiqiao Ye et al.   PLoS One

Biochemical and Computational Analysis Of LNX1 Interacting Proteins

(2011) Cheryl D. Wolting et al.   PLoS One

Local communication on and within bone controls bone remodeling

(2009) Kim Henriksen et al.   BONE

NOTCHing the bone: Insights into multi-functionality

(2009) Feyza Engin et al.   BONE

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

The multiple functions of Numb

(2009) Alberto Gulino et al.   EXPERIMENTAL CELL RESEARCH

Numb Regulates Post-endocytic Trafficking and Degradation of Notch1

(2009) Melanie A. McGill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 ubiquitin ligase LNX1p80 promotes the removal of claudins from tight junctions in MDCK cells

(2009) S. Takahashi et al.   JOURNAL OF CELL SCIENCE

Notch is activated in RANKL-induced osteoclast differentiation and resorption

(2008) Li Duan   Frontiers in Bioscience-Landmark

The Association of Notch2 and NF- B Accelerates RANKL-Induced Osteoclastogenesis

(2008) H. Fukushima et al.   MOLECULAR AND CELLULAR BIOLOGY

Dimorphic effects of Notch signaling in bone homeostasis

(2008) Feyza Engin et al.   NATURE MEDICINE

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption

(2008) Natalie A. Sims et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY