Article
Chemistry, Analytical
Chang Liu, Gongze Wang, Huan Ding, Ji Li, Yuanyuan Wu, Huirong Yao, Song He, Liancheng Zhao, Xianshun Zeng
Summary: The vinyl-bridged D-p-A structure of hemicyanine dye is sensitive to the change of microenvironmental viscosity, making it suitable for measuring viscosity change in living cells. A pyrene-and dehydropyridocolinium-containing fluorescent probe PyQz was developed for monitoring the change of viscosity in mitochondria during ferroptosis process, showing decreased solvatochromic effect and good chemical stability.
MICROCHEMICAL JOURNAL
(2023)
Article
Spectroscopy
Feng-Tao Yu, Ze Huang, Jia-Xiang Yang, Long-Mei Yang, Xian-Yun Xu, Jian-Yan Huang, Lin Kong
Summary: Two viscosity-sensitive fluorescent probes were designed and synthesized to localize in lysosome and mitochondria in living HeLa cells, respectively. The fluorescence quantum yield and two-photon absorption cross section of the probes were significantly increased with the increase of viscosity. Fluorescence lifetime imaging of the cells stained with the probes revealed the viscosity range of lysosome and mitochondria. This type of probe is of great importance for monitoring diseases associated with abnormal viscosity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Qian Chen, Xiao-Fan Zhang, Teng Wang, Xiao-Qun Cao, Shi-Li Shen
Summary: The researchers developed a near-infrared fluorescence probe that can detect viscosity changes and distinguish cancer cells from normal cells. The probe was successfully applied to in vivo viscosity imaging.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Yu-Fang Wei, Xiao-Feng Weng, Xin-Long Sha, Ru Sun, Yu-Jie Xu, Jian-Feng Ge
Summary: This study reported a novel fluorescent probe for simultaneous detection of viscosity fluctuation in mitochondria and lysosomes, showing great potential in cell experiments. The probe exhibited stronger fluorescence in cancer cells at low concentrations and could be used for early diagnosis of related diseases.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Bochao Chen, Shumei Mao, Yanyan Sun, Liyuan Sun, Ning Ding, Chengde Li, Jin Zhou
Summary: A mitochondria-targeted fluorescent probe NIR-V with 700 nm emission was designed to monitor cell viscosity changes with high selectivity and sensitivity, which was applied to detect intracellular viscosity and image pancreatic tissue in a diabetic mouse model. Probe NIR-V provides an effective way to diagnose viscosity related diseases.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Physical
Wei Quan, Guihua Zhang, Ling Huang, Wenhui Song, Weiying Lin
Summary: Studies have shown that changes in mitochondrial viscosity are closely related to its state, but existing probes cannot accurately image under depolarization conditions. To address this issue, researchers developed the MF-V1 probe, which effectively monitors changes in mitochondrial viscosity and successfully detected changes in viscosity in zebrafish and mice.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Analytical
Hui Wang, Hongtong Wang, Xiaoting Zhang, Mingyan Dong, Fang Huang, Ping Li, Bo Tang
Summary: This study successfully confirmed the decrease in mitochondrial Cys levels in mice with arthritis using a two-photon imaging probe, providing strong support for the development of new therapeutic approaches for related diseases.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Xingzong Wang, Lei Wang, Tengda Jin, Keju Sun, Jingyue Yang
Summary: Two dual-mode fluorescent probes responding to both pH and viscosity were designed and synthesized in this study based on inhibited intramolecular charge transfer (ICT) and twisted intramolecular charge transfer (TICT) processes. The fluorescence intensity of the probes would be doubly amplified at low pH and high viscosity, providing excellent contrast for biological imaging. Fluorescence imaging in living cells, tissue, and organs further demonstrated the selective visualization of cancer by the synthesized probes.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Biochemistry & Molecular Biology
Sukhvinder Dhiman, Rasdeep Kour, Satwinderjeet Kaur, Prabhpreet Singh, Subodh Kumar
Summary: A new fluorescent probe DMAS-Si was reported in this study for the simultaneous detection of mitochondrial viscosity and F- ion through different signals, showing significant potential for investigating the physiological state of mitochondria.
BIOORGANIC CHEMISTRY
(2022)
Article
Spectroscopy
Jun Tang, Ziyi Li, Chuchu Qiang, Yan Han, Lifang Yang, Li Zhu, Tan Dang, Gairong Chen, Yong Ye
Summary: In this study, a long-wavelength mitochondria-targeted fluorescence turn on probe TL was developed for the detection of ONOO-. TL exhibited excellent characteristics, including fast response time, high sensitivity, and specific emission wavelength. It also demonstrated good mitochondria targeting and visualization of both exogenous and endogenous ONOO- in biological systems. Furthermore, TL was used to monitor the up-regulation of ONOO- induced by high concentration of dexamethasone, suggesting its potential for studying the fluctuation of ONOO- in physiological and pathological systems.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Physical
Bingli Lu, Junling Yin, Cong Liu, Weiying Lin
Summary: A near-infrared fluorescent probe MI-F was developed to visualize the viscosity level of acute kidney injury (AKI) and evaluate the intervention ability of reduced glutathione on AKI. The study revealed an increase in viscosity under the pathology of AKI and demonstrated the inhibitory and preventive effect of early intake of reduced glutathione on kidney organ damage during AKI process. The research also indicated minimal impact of the early stage of AKI on other organs.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Analytical
Weijia Xu, Senyao Liu, Zhaoming Chen, Fapu Wu, Wenwen Cao, Yang Tian, Hu Xiong
Summary: In this study, a bichromatic fluorophore called Cy-914 was developed for the simultaneous diagnosis of NAFLD and metastatic intestinal cancer. Cy-914 showed different fluorescence signals at different wavelengths under acidic and neutral to slightly basic viscous conditions, and could monitor the progression of NAFLD. By visualizing different diseases in independent channels, this fluorophore improved fluorescence-guided surgery.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Jialiang Lu, Qianqian Wang, Zhaojun Wang, Jinguo Liu, Yu Guo, Chenghao Pan, Xin Li, Jinxin Che, Zheng Shi, Shuo Zhang
Summary: In this study, an effective targeted activatable fluorescent probe F1 was identified based on log P analysis. The probe showed good cell permeability, selectivity, and enhanced tumor tissue fluorescence in animal models, as well as selectivity in imaging clinical specimens of human colorectal cancer tissues.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiazhen Bao, Xuehui Cao, Kaili Ai, Yao Cui, Zhengang Han, Bo Zhou, Congde Huo
Summary: In this study, a dual-reaction-site and dual-channel turn-on fluorescent probe Cyan-S-Nap was developed for selectively detecting GSH. The probe exhibited two independent fluorescent channels in visible and near-infrared regions, allowing precise detection of GSH concentration fluctuations. The probe was also capable of imaging mitochondrial GSH in dual channels and monitoring changes in GSH levels modulated by reactive oxygen species in living cells and zebrafish.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Seonyoung Jo, Sihyun Kim, Yena Lee, Gayoung Kim, Sehoon Kim, Soojin Lee, Taek Seung Lee
Summary: A pyrene-based fluorescent molecular probe, Py2-5EG, was synthesized for optical detection of viscosity variation. The probe showed blue fluorescence in high viscosity medium and greenish blue fluorescence in low viscosity medium. The fluorescence colors were used to observe microscopic changes in cellular viscosity.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)